Results 41 to 50 of about 38,197 (138)

TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy

Life Science Alliance, 2022
TMBIM5 deficiency reduces mitochondrial K + /H + exchange. Mutation of the channel pore in mice destabilizes the protein and results in increased embryonic lethality and a skeletal myopathy.
Li Zhang, Felicia Dietsche, Bruno Seitaj, Liliana Rojas-Charry, Nadina Latchman, Dhanendra Tomar, Rob CI Wüst, Alexander Nickel, Katrin BM Frauenknecht, Benedikt Schoser, Sven Schumann, Michael J Schmeisser, Johannes vom Berg, Thorsten Buch, Stefanie Finger, Philip Wenzel, Christoph Maack, John W Elrod, Jan B Parys, Geert Bultynck, Axel Methner   +20 more
doaj   +1 more source

Role of mitochondrial potassium channels in ageing

Mitochondrion
Ageing is described as an inevitable decline in body functions over time and an increase in susceptibility to age-related diseases. Therefore, the increase of life expectancy is also viewed as a condition in which many elderly will develop age-related diseases and disabilities, such as cardiovascular, metabolic, neurological and oncological ones ...
Flori L., Spezzini J., Calderone V., Testai L.   +3 more
openaire   +2 more sources

Homozygous mutation in SLO3 leads to severe asthenoteratozoospermia due to acrosome hypoplasia and mitochondrial sheath malformations

Reproductive Biology and Endocrinology, 2022
Background Potassium channels are important for the structure and function of the spermatozoa. As a potassium transporter, the mSlo3 is essential for male fertility as Slo3 knockout male mice were infertile with the series of functional defects in sperm ...
Mingrong Lv, Chunyu Liu, Chunjie Ma, Hui Yu, Zhongmei Shao, Yang Gao, Yiyuan Liu, Huan Wu, Dongdong Tang, Qing Tan, Junqiang Zhang, Kuokuo Li, Chuan Xu, Hao Geng, Jingjing Zhang, Hang Li, Xiaohong Mao, Lei Ge, Feifei Fu, Kaixin Zhong, Yuping Xu, Fangbiao Tao, Ping Zhou, Zhaolian Wei, Xiaojin He, Feng Zhang, Yunxia Cao   +26 more
doaj   +1 more source

Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced ColitisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: The 2-pore potassium channel subfamily K member 9 (KCNK9) regulates intracellular calcium concentration and thus modulates cell survival and inflammatory signaling pathways.
Steffen Pfeuffer, Thomas Müntefering, Leoni Rolfes, Frederike Anne Straeten, Susann Eichler, Joel Gruchot, Vera Dobelmann, Tim Prozorovski, Boris Görg, Mihael Vucur, Carsten Berndt, Patrick Küry, Tobias Ruck, Stefan Bittner, Dominik Bettenworth, Thomas Budde, Tom Lüdde, Sven G. Meuth   +17 more
doaj   +1 more source

Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism

Frontiers in Physiology, 2018
Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single ...
Alexis R. Díaz-Vegas, Alex Cordova, Denisse Valladares, Denisse Valladares, Paola Llanos, Paola Llanos, Cecilia Hidalgo, Gaia Gherardi, Diego De Stefani, Cristina Mammucari, Rosario Rizzuto, Ariel Contreras-Ferrat, Enrique Jaimovich   +12 more
doaj   +1 more source

Potassium dependent rescue of a myopathy with core-like structures in mouse

eLife, 2015
Myopathies decrease muscle functionality. Mutations in ryanodine receptor 1 (RyR1) are often associated with myopathies with microscopic core-like structures in the muscle fiber. In this study, we identify a mouse RyR1 model in which heterozygous animals
M Gartz Hanson, Jonathan J Wilde, Rosa L Moreno, Angela D Minic, Lee Niswander   +4 more
doaj   +1 more source

A Novel Mitochondrial Potassium Channel in Embryonic Hippocampal Mitochondra [PDF]

Biophysical Journal, 2012
Since 1991, when in Nature Inoue and co-workers described the first potassium channel in the inner mitochondrial membrane, ATP-regulated (mitoKATP), four other channels were found. ATP-regulated (mitoKATP), large-conductance calcium activated (mitoBKCa), voltage-dependent (mitoKv1.3), intermediate-conductance calcium-activated potassium channel ...
Kajma, Anna, Bednarczyk, Piotr, Szewczyk, Adam   +2 more
openaire   +1 more source

Regulation of mitochondrial potassium BKCa channel by naringenin derivatives: application of a new cellular model

European Journal of Medicinal Chemistry Reports
Mitochondrial potassium (mitoK) channels play a crucial role in mitochondrial and cellular physiology. One of the best described mitoK channels is the mitochondrial large-conductance calcium-activated potassium (mitoBKCa) channel.
Aleksandra Sęk, Silvia Cammarone, Rafał P. Kampa, Karolina Pytlak, Barbara Kalenik, Joanna Lewandowska, Francesca Ghirga, Isabella Romeo, Omar Atrooz, Piotr Bednarczyk, Adam Szewczyk, Bruno Botta, Deborah Quaglio, Bogusz Kulawiak   +13 more
doaj   +1 more source

Impact of Mitochondrial Ca2+-Sensitive Potassium (mBKCa) Channels in Sildenafil-Induced Cardioprotection in Rats.

PLoS ONE, 2015
BackgroundMitochondrial large-conductance Ca2+-sensitive potassium (mBKCa) channels are involved in myocardial ischemic preconditioning. Their role in sildenafil-induced cardioprotection is unknown.
Friederike Behmenburg, Marianne Dorsch, Ragnar Huhn, David Mally, André Heinen, Markus W Hollmann, Marc M Berger   +6 more
doaj   +1 more source

Intracellular ion channels and cancer

Frontiers in Physiology, 2013
Several types of channels play a role in the maintenance of ion homeostasis in subcellular organelles including endoplasmatic reticulum, nucleus, lysosome, endosome and mitochondria.
Luigi eLeanza, Lucia eBiasutto, Antonella eManago, Erich eGulbins, Mario eZoratti, Ildikò eSzabò   +5 more
doaj   +1 more source