Results 41 to 50 of about 76,259 (184)
Surface Fluorescence Studies of Tissue Mitochondrial Redox State in Isolated Perfused Rat Lungs [PDF]
, 2012 We designed a fiber-optic-based optoelectronic fluorometer to measure emitted fluorescence from the auto-fluorescent electron carriers NADH and FAD of the mitochondrial electron transport chain (ETC).
Audi, Said H. +4 more
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Cell & Bioscience, 2020 Background Openers of mitochondrial adenosine triphosphate-dependent potassium (mKATP) channels like diazoxide increase reactive oxygen species (ROS) production in cardiac cells and reduce Ca2+ elevations produced by ischemia–reperfusion, protecting the ...
Joice T. Gavali +3 more
doaj +1 more source
BK in Double-Membrane Organelles: A Biophysical, Pharmacological, and Functional Survey
Frontiers in Physiology, 2021 In the 1970s, calcium-activated potassium currents were recorded for the first time. In 10years, this Ca2+-activated potassium channel was identified in rat skeletal muscle, chromaffin cells and characterized in skeletal muscle membranes reconstituted in
Naileth González-Sanabria +4 more
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Overexpression of Large-Conductance Calcium-Activated Potassium Channels in Human Glioblastoma Stem-Like Cells and Their Role in Cell Migration [PDF]
, 2017 Glioblastomas (GBMs) are brain tumors characterized by diffuse invasion of cancer cells into the healthy brain parenchyma, and establishment of secondary foci. GBM cells abundantly express large-conductance, calcium-activated potassium (BK) channels that
Abdullaev +49 more
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Mitochondrial potassium channels and reactive oxygen species [PDF]
FEBS Letters, 2010 Pretreatment of tissues with potassium channel openers (KCO's) has been observed to be cytoprotective in a broad variety of insults. This phenomenon has been proposed to be intimately linked to activation of mitochondrial potassium channels which apparently modulate the mitochondrial production of reactive oxygen species (ROS).
Malinska, Dominika +2 more
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Mitochondrial ATP-Dependent Potassium Channels [PDF]
Circulation, 1998 Background—Brief interruptions of coronary blood flow paradoxically protect the heart from subsequent prolonged ischemia. The basis of such endogenous cardioprotection, known as “ischemic preconditioning,” remains uncertain. Pharmacological evidence has implicated ATP-dependent potassium (KATP) channels in the mechanism of preconditioning; however, the
Y, Liu, T, Sato, B, O'Rourke, E, Marban
openaire +2 more sources
KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury. [PDF]
PLoS ONE, 2014 Mitochondrial potassium channels have been implicated in myocardial protection mediated through pre-/postconditioning. Compounds that open the Ca2+- and voltage-activated potassium channel of big-conductance (BK) have a pre-conditioning-like effect on ...
Ewa Soltysinska +20 more
doaj +1 more source
Hypoxic regulation of ion channel function and expression [PDF]
, 2002 Acute hypoxia regulates the activity of specific ion channels in a rapid and reversible manner. Such effects underlie appropriate cellular responses to hypoxia which are designed to initiate cardiorespiratory reflexes and contribute importantly to other ...
Peers, C.
core +1 more source
SLO-2 is cytoprotective and contributes to mitochondrial potassium transport. [PDF]
PLoS ONE, 2011 Mitochondrial potassium channels are important mediators of cell protection against stress. The mitochondrial large-conductance "big" K(+) channel (mBK) mediates the evolutionarily-conserved process of anesthetic preconditioning (APC), wherein exposure ...
Andrew P Wojtovich +5 more
doaj +1 more source
Ammonia toxicity: from head to toe? [PDF]
, 2016 Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues.
Dasarathy, Srinivasan +6 more
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