Results 61 to 70 of about 38,197 (138)
Frontiers in Pharmacology, 2019 Spinal cord ischemia-reperfusion injury (SCI/R) is a rare but devastating disorder with a poor prognosis. Small conductance calcium-activated K+ (SK/KCa) channels are a family of voltage-independent potassium channels that are shown to participate in the
Jie Zhu +5 more
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Modulation of the Mitochondrial Potassium Channel Activity by Infrared Light [PDF]
Biophysical Journal, 2018 Mitochondrial potassium channels are regulated by a variety of ligands. Moreover, gaseous signaling molecules such as NO or CO were recognized as new and important modulators of mitochondrial function. Recently, also infrared light being absorbed by molecules and/or protein complexes was shown to modulate function of mitochondria.
Adam Szewczyk, Piotr Bednarczyk
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Molecular Bases of Brain Preconditioning
Frontiers in Neuroscience, 2017 Preconditioning of the brain induces tolerance to the damaging effects of ischemia and prevents cell death in ischemic penumbra. The development of this phenomenon is mediated by mitochondrial adenosine triphosphate-sensitive potassium (KATP+) channels ...
Oleg G. Deryagin +10 more
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Molecular Mechanisms in Exercise-Induced Cardioprotection
Cardiology Research and Practice, 2011 Physical inactivity is increasingly recognized as modifiable behavioral risk factor for cardiovascular diseases. A partial list of proposed mechanisms for exercise-induced cardioprotection include induction of heat shock proteins, increase in cardiac ...
Saeid Golbidi, Ismail Laher
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Mitochondrial preconditioning: a potential neuroprotective strategy
Frontiers in Aging Neuroscience, 2010 Mitochondria have long been known as the powerhouse of the cell. However, these organelles are also pivotal players in neuronal cell death. Mitochondrial dysfunction is a prominent feature of chronic brain disorders, including Alzheimer's and ...
Sónia C Correia +17 more
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Physiological Reports, 2019 There has been a resurgence of interest in the volume‐regulated anion channel (VRAC) since the recent cloning of the LRRC8A‐E gene family that encodes VRAC.
Aqeela Afzal +6 more
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PLoS GeneticsThe Shaker/Kv1 subfamily of voltage-gated potassium (K+) channels is essential for modulating membrane excitability. Their loss results in prolonged depolarization and excessive calcium influx.
Longjun Pu +11 more
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Glibenclamide Mimics Metabolic Effects of Metformin in H9c2 Cells
Cellular Physiology and Biochemistry, 2017 Background: Sulfonylureas, such as glibenclamide, are antidiabetic drugs that stimulate beta-cell insulin secretion by binding to the sulfonylureas receptors (SURs) of adenosine triphosphate-sensitive potassium channels (KATP).
Barbara Salani +8 more
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Serofendic Acid Protects Against Myocardial Ischemia–Reperfusion Injury in Rats
Journal of Pharmacological Sciences, 2014 .: We previously reported that serofendic acid, a lipophilic extract of fetal calf serum, protects against oxidative stress in primary culture of neonatal rat cardiomyocytes.
Tadaaki Ioroi +7 more
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Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs
Medicinal Research Reviews, 2014 AbstractBrief periods of ischemia are known to confer to the myocardium an increased resistance to the injury due to a later and more prolonged ischemic episode. This phenomenon, known as ischemic preconditioning (IPreC), is ensured by different biological mechanisms.
TESTAI, LARA +4 more
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