Results 61 to 70 of about 38,961 (265)

Mitochondrial KATP channels contribute to the protective effects of hydrogen sulfide against impairment of central chemoreception of rat offspring exposed to maternal cigarette smoke.

PLoS ONE, 2020
We previously reported that maternal cigarette smoke (CS) exposure resulted in impairment of central chemoreception and induced mitochondrial dysfunction in offspring parafacial respiratory group (pFRG), the kernel for mammalian central chemoreception ...
Fang Lei, Wen Wang, Yating Fu, Ji Wang, Yu Zheng   +4 more
doaj   +1 more source

Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism

Cell Death and Disease, 2021
Cellular energy metabolism is fundamental for all biological functions. Cellular proliferation requires extensive metabolic reprogramming and has a high energy demand. The Kv1.3 voltage-gated potassium channel drives cellular proliferation.
Faye L. Styles, Moza M. Al-Owais, Jason L. Scragg, Eulashini Chuntharpursat-Bon, Nishani T. Hettiarachchi, Jonathan D. Lippiat, Aisling Minard, Robin S. Bon, Karen Porter, Piruthivi Sukumar, Chris Peers, Lee D. Roberts   +11 more
doaj   +1 more source

Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11.1 activation in breast cancer cells and PDOs

Redox Biology, 2021
Potassium channels are important regulators of cellular homeostasis and targeting these proteins pharmacologically is unveiling important mechanisms in cancer cell biology.
Vitalyi Senyuk, Najmeh Eskandari, Ying Jiang, Rebeca Garcia-Varela, Rachel Sundstrom, Luigi Leanza, Roberta Peruzzo, Mark Burkard, Richard D. Minshall, Saverio Gentile   +9 more
doaj   +1 more source

K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect

, 2002
Background— Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.
Hubank, M, Stephanou, A., Chanalaris, A., Townsend, P. A., Lawrence, K. M., Townsend, P A, Lawrence, KM, Knight, RA, Ferrari, R., Chanalaris, A, Scarabelli, T., Scarabelli, T, Hubank, M., Pasini, E., Townsend, PA, Latchman, D S, Tinker, A., Latchman, D. S., Knight, R A, Pasini, E, Comini, L, Lawrence, K M, Latchman, DS, Tinker, A, Ferrari, R, Comini, L., Knight, R. A., Stephanou, A   +27 more
core   +1 more source

Combining Fret and Super‐Resolution Microscopy Reveals Kinase Activation and Mitochondrial Activity at the Nanoscale

Advanced Science, EarlyView.
BioSenSRRF is an open‐source workflow that combines conventional FRET biosensors with SRRF reconstruction to generate sub‐diffraction FRET index maps on standard microscopes. The pipeline integrates automated image registration, SRRF reconstruction, quantitative FRET index calculation, and random line‐based hotspot analysis to uncover AURKA‐dependent ...
Nicolas Y. Jolivet, Pierre‐Jean Desmaison, Xavier Pinson, Arthur Masson, Olivier Delalande, Giulia Bertolin   +5 more
wiley   +1 more source

11,12-EET stimulates the association of BK channel α and β(1) subunits in mitochondria to induce pulmonary vasoconstriction. [PDF]

PLoS ONE, 2012
In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca(2+)-activated potassium (BK) channels.
Annemarieke E Loot, Isabelle Moneke, Benjamin Keserü, Matthias Oelze, Tetyana Syzonenko, Andreas Daiber, Ingrid Fleming   +6 more
doaj   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Mitochondrial potassium channels: New properties and functions

Biochimica et Biophysica Acta (BBA) - Bioenergetics
Mitochondria are recently implicated in phenomena such as cytoprotection, cellular senescence, tumor metabolism, and inflammation. The basis of these processes relies on biochemical functions of mitochondria such as the synthesis of reactive oxygen species or biophysical properties such as the integrity of the inner mitochondrial membrane.
Adam, Szewczyk, Piotr, Bednarczyk, Bogusz, Kulawiak, Monika, Żochowska, Barbara, Kalenik, Joanna, Lewandowska, Karolina, Pytlak, Shur, Gałecka, Antoni, Wrzosek, Piotr, Koprowski   +9 more
openaire   +3 more sources

Mitochondrial Dysfunction and Ion Imbalance in a Rat Model of Hemodialysis-Induced Myocardial Stunning

Biomedicines
Background/Objectives: Hemodialysis-induced myocardial stunning (HIMS) is a frequent complication in patients undergoing maintenance hemodialysis, characterized by transient left ventricular dysfunction due to ischemic episodes. Mitochondrial dysfunction
Yuxin Nie, Liyu Lin, Qiang Yang, Jiachang Hu, Minmin Sun, Fangfang Xiang, Xuesen Cao, Jinbo Yu, Yaqiong Wang, Jie Teng, Xiaoqiang Ding, Bo Shen, Zhen Zhang   +12 more
doaj   +1 more source

Activation of SK/KCa Channel Attenuates Spinal Cord Ischemia-Reperfusion Injury via Anti-oxidative Activity and Inhibition of Mitochondrial Dysfunction in Rabbits

Frontiers in Pharmacology, 2019
Spinal cord ischemia-reperfusion injury (SCI/R) is a rare but devastating disorder with a poor prognosis. Small conductance calcium-activated K+ (SK/KCa) channels are a family of voltage-independent potassium channels that are shown to participate in the
Jie Zhu, Li-Kun Yang, Wei-Liang Chen, Wei Lin, Yu-Hai Wang, Tao Chen   +5 more
doaj   +1 more source