Results 61 to 70 of about 76,259 (184)
LETM1-Mediated K+ and Na+ Homeostasis Regulates Mitochondrial Ca2+ Efflux [PDF]
, 2017 HIGHLIGHTS \u2022 Monovalent cation homeostasis is dysregulated upon LETM1 depletion \u2022 K+/H+ exchange activity is decreased in LETM1 knockdown cells \u2022 LETM1 depletion results in K+ accumulation in the mitochondrial matrix \u2022 LETM1 knockdown
Andrea Mattarei +8 more
core +3 more sources
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: The 2-pore potassium channel subfamily K member 9 (KCNK9) regulates intracellular calcium concentration and thus modulates cell survival and inflammatory signaling pathways.
Steffen Pfeuffer +17 more
doaj +1 more source
Potassium dependent rescue of a myopathy with core-like structures in mouse
eLife, 2015 Myopathies decrease muscle functionality. Mutations in ryanodine receptor 1 (RyR1) are often associated with myopathies with microscopic core-like structures in the muscle fiber. In this study, we identify a mouse RyR1 model in which heterozygous animals
M Gartz Hanson +4 more
doaj +1 more source
Protection Against Cardiac Injury by Small Ca\u3csup\u3e2 +\u3c/sup\u3e-Sensitive K\u3csup\u3e+\u3c/sup\u3e Channels Identified in Guinea Pig Cardiac Inner Mitochondrial Membrane [PDF]
, 2013 We tested if small conductance, Ca2 +‐sensitive K+ channels (SKCa) precondition hearts against ischemia reperfusion (IR) injury by improving mitochondrial (m) bioenergetics, if O2‐derived free radicals are required to initiate protection via SKCa ...
Aldakkak, Mohammed +9 more
core +1 more source
The Upregulation of α2δ-1 Subunit Modulates Activity-Dependent Ca2+ Signals in Sensory Neurons. [PDF]
, 2015 As auxiliary subunits of voltage-gated Ca(2+) channels, the α2δ proteins modulate membrane trafficking of the channels and their localization to specific presynaptic sites.
Cassidy, JS +3 more
core +1 more source
Mitochondrial potassium channels: From pharmacology to function
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2006 Mitochondrial potassium channels, such as ATP-regulated or large conductance Ca2+ -activated and voltage gated channels were implicated in cytoprotective phenomenon in different tissues. Basic effects of these channels activity include changes in mitochondrial matrix volume, mitochondrial respiration and membrane potential, and generation of reactive ...
Szewczyk, Adam +6 more
openaire +2 more sources
Frontiers in Physiology, 2018 Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single ...
Alexis R. Díaz-Vegas +12 more
doaj +1 more source
Signaling and cellular mechanisms in cardiac protection by ischemic and pharmacological preconditioning [PDF]
, 2018 Ischemic preconditioning (IPC) is a defensive adaptive cellular phenomenon. Brief ischemic stimuli render the heart resistant to subsequent similar stress. Signaling for IPC and pharmacologically induced preconditioning involves several G-protein coupled
Schaub, Marcus, Zaugg, Michael
core
The Mitochondrial K Channel as a Receptor for Potassium Channel Openers [PDF]
Journal of Biological Chemistry, 1996 The biochemical properties of the mitochondrial KATP channel are very similar to those of plasma membrane KATP channels, including inhibition by low concentrations of ATP and glyburide (Paucek, P., Mironova, G., Mahdi, F., Beavis, A. D., Woldegiorgis, G., and Garlid, K. D. (1992) J. Biol. Chem. 267, 26062-26069).
K D, Garlid +4 more
openaire +2 more sources
PLoS ONE, 2015 BackgroundMitochondrial large-conductance Ca2+-sensitive potassium (mBKCa) channels are involved in myocardial ischemic preconditioning. Their role in sildenafil-induced cardioprotection is unknown.
Friederike Behmenburg +6 more
doaj +1 more source