Results 81 to 90 of about 38,961 (265)

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

Advanced Science, EarlyView.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander, Maria del Pilar Palacios Cisneros, Clara Certa, Megan Stierli, Katharina Beck, Nicolas Färber, Lisa Blank, Fiona Tanner, Eric Mühlberg, Sabrina Wohlfart, Christian Kleist, Jörg Huwyler, Gert Fricker, Walter Mier, Philipp Uhl   +14 more
wiley   +1 more source

Molecular Bases of Brain Preconditioning

Frontiers in Neuroscience, 2017
Preconditioning of the brain induces tolerance to the damaging effects of ischemia and prevents cell death in ischemic penumbra. The development of this phenomenon is mediated by mitochondrial adenosine triphosphate-sensitive potassium (KATP+) channels ...
Oleg G. Deryagin, Svetlana A. Gavrilova, Khalil L. Gainutdinov, Khalil L. Gainutdinov, Anna V. Golubeva, Vyatcheslav V. Andrianov, Vyatcheslav V. Andrianov, Guzel G. Yafarova, Guzel G. Yafarova, Sergey V. Buravkov, Vladimir B. Koshelev   +10 more
doaj   +1 more source

The distribution and function of the ATP-sensitive potassium channel subunit Kir6.1 in cardiac and skeletal muscle cell lines.

, 2007
ATP-sensitive potassium channels (KAtp) are present in the plasma membrane of a number of tissues but are also present on endomembranes such as the endoplasmic reticulum (ER) and mitochondria.
Ng, K-E.
core  

Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs

, 1999
Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
David W. Busija, Perciaccante, J. V., Ferenc Domoki, James V. Perciaccante, Domoki, Ferenc, Bari, Ferenc, Ferenc Bari, Roland Veltkamp, Veltkamp, R.   +8 more
core   +1 more source

SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake [PDF]

, 2016
Mitochondrial calcium ([Ca(2+)]m) overload and changes in mitochondrial metabolism are key players in neuronal death. Small conductance calcium-activated potassium (SK) channels provide protection in different paradigms of neuronal cell death.
Krasel, Cornelius, Ganjam, G K, Krasel, C., Ganjam, G.K., Lena Magerhans, Magerhans, Lena, Matschke, Lina A, Fabiana Perocchi, Gerding, A., Culmsee, C., Bakker, Barbara, Tammo Meyer, Meyer, T., Matschke, Lina, Bünemann, M., Ganjam, Goutham K, Lina Matschke, Bakker, B.M., Honrath, Birgit, Perocchi, F., Stefan Strack, Bakker, Barbara M, Decher, Niels, Bünemann, Moritz, Birgit Honrath, Amalia M Dolga, Gerding, Albert, Dolga, Amalia Mihalea, Zischka, H., Strack, S., Dolga, Amalia Mihalea; id_orcid, Cornelius Krasel, Bunemann, M, Perocchi, Fabiana, Hans Zischka, Dolga, Amalia M, Decher, N, Decher, N., Dolga, Amalia M; id_orcid, Culmsee, Carsten, Meyer, Tammo, Zischka, Hans, Strack, Stefan, Barbara M Bakker, Goutham K Ganjam, Carsten Culmsee, Bakker, Barbara M; id_orcid, Strack, S, Culmsee, C, Magerhans, L., Moritz Bünemann, Matschke, L., Albert Gerding, Honrath, B., Bakker, Barbara; id_orcid, Niels Decher, Dolga, A.M.   +56 more
core   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection

, 2004
Background - Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial reactive oxygen species (ROS) signaling.
Wynne, A, Duchen, M, Yellon, D, Hausenloy, D   +3 more
core  

NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice

Advanced Science, EarlyView.
In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu, Yulu Yang, Zhiqi Hao, Jing Xu, Huibo Zhao, Qiang Zhang, Deyong Ren, Xia Li, Guojun Dong, Lan Shen, Li Zhu, Jiang Hu, Zhenyu Gao, Qing Li, Qian Qian, Guangheng Zhang   +15 more
wiley   +1 more source

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

Angewandte Chemie, EarlyView.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič‐Raščan, Bostjan Markelc, Tim Bozic, Masa Omerzel, Tanja Jesenko, Maja Cemazar, Katja Kološa, Bojana Žegura, Miha Virant, Matic Lozinšek, Hai M. Nguyen, Joshua A. Nasburg, Heike Wulff, Maxime Gueguinou, Valerije Vrček, Veronica Carpanese, Ildiko Szabo, Luis A. Pardo, Tihomir Tomašič, Lucija Peterlin Mašič, Andrej Emanuel Cotman   +27 more
wiley   +2 more sources

Molecular Mechanisms in Exercise-Induced Cardioprotection

Cardiology Research and Practice, 2011
Physical inactivity is increasingly recognized as modifiable behavioral risk factor for cardiovascular diseases. A partial list of proposed mechanisms for exercise-induced cardioprotection include induction of heat shock proteins, increase in cardiac ...
Saeid Golbidi, Ismail Laher
doaj   +1 more source