Results 81 to 90 of about 76,259 (184)

Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae [PDF]

, 2019
Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments.
Balliano, Gianni, Bianchi, Michele Maria, Cirigliano, Angela, Macone, Alberto, Negri, Rodolfo, Oliaro-Bosso, Simonetta, Rinaldi, Teresa   +6 more
core   +2 more sources

Mitochondrial Dysfunction and Ion Imbalance in a Rat Model of Hemodialysis-Induced Myocardial Stunning

Biomedicines
Background/Objectives: Hemodialysis-induced myocardial stunning (HIMS) is a frequent complication in patients undergoing maintenance hemodialysis, characterized by transient left ventricular dysfunction due to ischemic episodes. Mitochondrial dysfunction
Yuxin Nie, Liyu Lin, Qiang Yang, Jiachang Hu, Minmin Sun, Fangfang Xiang, Xuesen Cao, Jinbo Yu, Yaqiong Wang, Jie Teng, Xiaoqiang Ding, Bo Shen, Zhen Zhang   +12 more
doaj   +1 more source

Diabetes mellitus and ischemic heart disease. the role of ion channels [PDF]

, 2018
Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic ...
De Marchis, Marialaura, D’Amato, Andrea, Fedele, Francesco, Mancone, Massimo, Netti, Lucrezia, Palmirotta, Raffaele, Pucci, Mariateresa, Severino, Paolo, Volterrani, Maurizio   +8 more
core   +2 more sources

AMP-activated protein kinase inhibits K_v1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation [PDF]

, 2016
KEY POINTS: Progression of hypoxic pulmonary hypertension is thought to be due, in part, to suppression of voltage‐gated potassium channels (K(v)) in pulmonary arterial smooth muscle by hypoxia, although the precise molecular mechanisms have been unclear.
A. Mark Evans, Amira D. Mahmoud, Andersen, Archer, Archer, Bain, Bartsch, Blom, Bonnet, Bonnet, Brevnova, Burg, Chang, Cheung, Cidad, Cidad, Comes, Corton, D. Grahame Hardie, David, David Fedida, Dipp, Egan, Ekhterae, Ekhterae, El-Mir, Euler, Evans, Evans, Evans, Fiona A. Ross, Firth, Firth, Firth, Gomez-Galeno, Goncharov, Goransson, Gowans, Hardie, Hardie, Hardie, Hardie, Hawley, Holmes, Hunter, Ibe, Ikematsu, Javier Moral-Sanz, Jodene Eldstrom, Jones, Kato, Krick, Kwak, Lahm, Lang, Lu, Macias, Martens, Mia, Michelakis, Michelakis, Moral-Sanz, Morales-Cano, Moudgil, Olschewski, Owen, Platoshyn, Platoshyn, Platoshyn, Post, Pozeg, Prieto-Lloret, Remillard, Robertson, Ross, Ross, Sakamoto, Scott, Scott, Smirnov, Sweeney, Tipparaju, Vallejo-Gracia, Wang, Williams, Wilson, Xiao, Yuan, Yuan   +88 more
core   +3 more sources

The uniqueness of the plant mitochondrial potassium channel

BMB Reports, 2013
The ATP-inhibited Plant Mitochondrial K(+) Channel (PmitoKATP) was discovered about fifteen years ago in Durum Wheat Mitochondria (DWM). PmitoKATP catalyses the electrophoretic K(+) uniport through the inner mitochondrial membrane; moreover, the co-operation between PmitoKATP and K(+)/H(+) antiporter allows such a great operation of a K(+) cycle to ...
PASTORE, DONATO, Soccio, Mario, Laus, Maura Nicoletta, D. Trono   +3 more
openaire   +3 more sources

Optical Imaging of Lipopolysaccharide-induced Oxidative Stress in Acute Lung Injury from Hyperoxia and Sepsis [PDF]

, 2013
Reactive oxygen species (ROS) have been implicated in the pathogenesis of many acute and chronic pulmonary disorders such as acute lung injury (ALI) in adults and bronchopulmonary dysplasia (BPD) in premature infants.
Audi, Said H., Eis, Annie L., Konduri, Girija G., Maleki, Sepideh, Ranji, Mahsa, Sepehr, Reyhaneh, Staniszewski, Kevin   +6 more
core   +3 more sources

A Novel Mitochondrial Potassium Channel in Embryonic Hippocampal Mitochondra [PDF]

Biophysical Journal, 2012
Since 1991, when in Nature Inoue and co-workers described the first potassium channel in the inner mitochondrial membrane, ATP-regulated (mitoKATP), four other channels were found. ATP-regulated (mitoKATP), large-conductance calcium activated (mitoBKCa), voltage-dependent (mitoKv1.3), intermediate-conductance calcium-activated potassium channel ...
Kajma, Anna, Bednarczyk, Piotr, Szewczyk, Adam   +2 more
openaire   +1 more source

Do K_ATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? [PDF]

, 2000
The objective was to investigate whether myocardial adenosine triphosphate-sensitive K⁺ (K_ATP) channels open during the first 10 min of regional ischaemia in Langendorff-perfused rat hearts.
MacKenzie, I., Northover, B.J., Workman, A.J.   +2 more
core   +1 more source

K(ATP) channel opener diazoxide prevents neurodegeneration: a new mechanism of action via antioxidative pathway activation. [PDF]

PLoS ONE, 2013
Pharmacological modulation of ATP-sensitive potassium channels has become a promising new therapeutic approach for the treatment of neurodegenerative diseases due to their role in mitochondrial and cellular protection.
Noemí Virgili, Pilar Mancera, Blanca Wappenhans, Georgina Sorrosal, Knut Biber, Marco Pugliese, Juan F Espinosa-Parrilla   +6 more
doaj   +1 more source

Cellular excitability and the regulation of functional neuronal identity: from gene expression to neuromodulation [PDF]

, 2006
The intrinsic properties of a neuron determine the translation of synaptic input to axonal output. It is this input– output relationship that is the heart of all nervous system activity.
Baines, Richard A., Hempel, Chris M., Li, L. (Lingjun), Liss, Birgit, Misonou, Hiroaki, Schulz, David J.   +5 more
core   +2 more sources