Results 71 to 80 of about 5,284,490 (388)

Simulation and calculation of the contribution of hyperpolarization-activated cyclic nucleotide-gated channels to action potentials [PDF]

Archives of Biological Sciences, 2016
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, which mediates the influx of cations, has an important role in action potential generation.
Liao Liping, Lin Xianguang, Hu Jielin, Wu Xin, Yang Xiaofei, Wang Wei, Li Chenhong   +6 more
doaj   +1 more source

Consequences of somatic mutations of GIRK1 detected in primary malign tumors on expression and function of G-protein activated, inwardly rectifying, K+ channels

Frontiers in Oncology, 2022
A search in the GDC Data Portal revealed 304 documented somatic mutations of the KCNJ3 gene in primary tumors (out of 10.202 cases). Most affected tumor types were carcinomas from uterus, skin and lung, while breast cancer exerted the lowest number of ...
Brigitte Pelzmann, Brigitte Pelzmann, Ahmed Hatab, Ahmed Hatab, Susanne Scheruebel, Susanne Scheruebel, Sonja Langthaler, Theresa Rienmueller, Armin Sokolowski, Astrid Gorischek, Astrid Gorischek, Dieter Platzer, Dieter Platzer, Klaus Zorn-Pauly, Klaus Zorn-Pauly, Stephan W. Jahn, Thomas Bauernhofer, Thomas Bauernhofer, Wolfgang Schreibmayer, Wolfgang Schreibmayer   +19 more
doaj   +1 more source

Fluorescent Probes to Image the K_Ca3.1 Channel in Tumor Cells

Pharmaceutics
Background/Objectives: The Ca2+-activated K+ channel KCa3.1 is not only involved in physiological processes such as immune reactions and control of vascular tone, but is highly expressed in various tumor entities.
Insa Thale, Elke Naß, Laura Vinnenberg, Luca Matteo Todesca, Thomas Budde, Ivan Maisuls, Cristian A. Strassert, Albrecht Schwab, Bernhard Wünsch   +8 more
doaj   +1 more source

Regulation of the Mitochondrial BK_Ca Channel by the Citrus Flavonoid Naringenin as a Potential Means of Preventing Cell Damage

Molecules, 2020
Naringenin, a flavanone obtained from citrus fruits and present in many traditional Chinese herbal medicines, has been shown to have various beneficial effects on cells both in vitro and in vivo.
Anna Kicinska, Rafał P. Kampa, Jan Daniluk, Aleksandra Sek, Wieslawa Jarmuszkiewicz, Adam Szewczyk, Piotr Bednarczyk   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Functional correlates of clinical phenotype and severity in recurrent SCN2A variants

Communications Biology, 2022
A comprehensive biophysical analysis of disease-associated mutations in the voltage-gated sodium channel gene, SCN2A, suggests that dynamic action potential clamp may be a better predictor than voltage clamp of how these mutations alter neuronal ...
Géza Berecki, Katherine B. Howell, Jacqueline Heighway, Nelson Olivier, Jill Rodda, Isabella Overmars, Danique R. M. Vlaskamp, Tyson L. Ware, Simone Ardern-Holmes, Gaetan Lesca, Michael Alber, Pierangelo Veggiotti, Ingrid E. Scheffer, Samuel F. Berkovic, Markus Wolff, Steven Petrou   +15 more
doaj   +1 more source

Ion channels: structural basis for function and disease. [PDF]

, 1996
Ion channels are ubiquitous proteins that mediate nervous and muscular function, rapid transmembrane signaling events, and ionic and fluid balance. The cloning of genes encoding ion channels has led to major strides in understanding the mechanistic basis
Goldstein, SA
core   +1 more source

Triggering on hard probes in heavy ion collisions with CMS [PDF]

, 2007
We present a study of the CMS trigger system in heavy-ion collisions. Concentrating on two physics channels, dimuons from decays of quarkonia and single jets, we evaluate a possible trigger strategy for Pb+Pb running that relies on event selection solely
Betts R, CMS Collaboration, CMS Collaboration, CMS Collaboration, G Roland, the CMS Collaboration   +5 more
core   +2 more sources

Cyclodextrin ion channels

Org. Biomol. Chem., 2014
Cyclodextrin ion channels, assembled by click chemistry, exhibit mechanistically diverse behaviors including transient blockage by hydrophobic guests.
Jonathan K W, Chui, T M, Fyles
openaire   +3 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source