Results 71 to 80 of about 5,224,105 (413)
Molecules, 2020 Naringenin, a flavanone obtained from citrus fruits and present in many traditional Chinese herbal medicines, has been shown to have various beneficial effects on cells both in vitro and in vivo.
Anna Kicinska +6 more
doaj +1 more source
Functional correlates of clinical phenotype and severity in recurrent SCN2A variants
Communications Biology, 2022 A comprehensive biophysical analysis of disease-associated mutations in the voltage-gated sodium channel gene, SCN2A, suggests that dynamic action potential clamp may be a better predictor than voltage clamp of how these mutations alter neuronal ...
Géza Berecki +15 more
doaj +1 more source
Cannabinoid interactions with ion channels and receptors
Channels, 2019 Cannabidiol (CBD), the non-psychoactive component of Cannabis sativa, acts on a diverse selection of membrane proteins with promising therapeutic potential in epilepsy and chronic pain. One such protein is the voltage-gated sodium channel (Nav).
Abeline R. Watkins
semanticscholar +1 more source
Evolving theoretical descriptions of heavy-ion fusion :from phenomenological to microscopic approaches [PDF]
, 2017 We overview the current status of theoretical approaches for heavy-ion fusion reactions at subbarrier energies. We particularly discuss theoretical challenges in the coupled-channels approach, that include i) a description of deep subbarrier hindrance of
Hagino, K.
core +2 more sources
Redox Regulation of Mitochondrial Potassium Channels Activity
AntioxidantsRedox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (
Joanna Lewandowska +3 more
doaj +1 more source
Ion channels as therapeutic antibody targets
mAbs, 2018 It is now well established that antibodies have numerous potential benefits when developed as therapeutics. Here, we evaluate the technical challenges of raising antibodies to membrane-spanning proteins together with enabling technologies that may ...
C. J. Hutchings +2 more
semanticscholar +1 more source
Ion Channel Reconstitution [PDF]
Biophysical Journal, 2012 Since the discovery of the possible solubilization of membrane proteins and their isolation from other membrane constituents (purification), different methods were developed to reconstitute ion channel proteins into artificial lipid bilayers. These membrane proteins were then fully functional when correctly oriented and inserted in a lipid bilayer. The
Andrea Brueggemann +3 more
openaire +2 more sources
Quantum coherence on selectivity and transport of ion channels [PDF]
arXiv, 2022 Recently, it has been suggested that ion channel selectivity filter may exhibit quantum coherence, which may be appropriate to explain ion selection and conduction processes. Potassium channels play a vital role in many physiological processes. One of their main physiological functions is the efficient and highly selective transfer of K+ ions through ...
arxiv
Ion Channels in Glioblastoma [PDF]
ISRN Neurology, 2011 Glioblastoma is the most common primary brain tumor with the most dismal prognosis. It is characterized by extensive invasion, migration, and angiogenesis. Median survival is only 15 months due to this behavior, rendering focal surgical resection ineffective and adequate radiotherapy impossible. At this moment, several ion channels have been implicated
openaire +2 more sources
Fluorescent Probes to Image the KCa3.1 Channel in Tumor Cells
PharmaceuticsBackground/Objectives: The Ca2+-activated K+ channel KCa3.1 is not only involved in physiological processes such as immune reactions and control of vascular tone, but is highly expressed in various tumor entities.
Insa Thale +8 more
doaj +1 more source