Results 101 to 110 of about 1,266,199 (347)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Numerical Study of Salt Ion Transport in Electromembrane Systems with Ion-Exchange Membranes Having Geometrically Structured Surfaces

Mathematics
This article is devoted to numerically modeling the effect of the geometric modification of the surfaces of ion-exchange membranes in electromembrane systems (EMSs) on the salt ion transport using a 2D mathematical model of the transport process in the ...
Evgenia Kirillova, Natalia Chubyr, Anna Kovalenko, Mahamet Urtenov   +3 more
doaj   +1 more source

Position of the third Na+ site in the aspartate transporter GltPh and the human glutamate transporter, EAAT1. [PDF]

PLoS ONE, 2012
Glutamate transport via the human excitatory amino acid transporters is coupled to the co-transport of three Na(+) ions, one H(+) and the counter-transport of one K(+) ion.
Turgut Bastug, Germano Heinzelmann, Serdar Kuyucak, Marietta Salim, Robert J Vandenberg, Renae M Ryan   +5 more
doaj   +1 more source

The Physiological Basis for Altered Na\u3csup\u3e+\u3c/sup\u3e and Cl\u3csup\u3e-\u3c/sup\u3e Movement Across the Gills of Rainbow Trout (\u3cem\u3eOncorhynchus mykiss\u3c/em\u3e) in Alkaline (pH=9.5) Water [PDF]

, 1999
To test the hypothesis that internal ion imbalances at high pH are caused by altered branchial ion transporting capacity and permeability, radiotracers (24Na+ and 36Cl-) were used to measure ion movements across the gills of intact rainbow trout ...
Laurent, Pierre, Wilkie, Michael P., Wood, Chris M.   +2 more
core   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Dynamics of water and solute transport in polymeric reverse osmosis membranes via molecular dynamics simulations

, 2016
The Angstrom-scale transport characteristics of water and six different solutes, methanol, ethanol, 2-propanol, urea, Na+, and Cl-, were studied for a polyamide reverse osmosis (RO) membrane, FT-30, using non-equilibrium molecular dynamics (NEMD ...
Keten, Sinan, Lueptow, Richard M., Shen, Meng   +2 more
core   +1 more source

Ion channels and transporters in osteoclasts

Archives of Biochemistry and Biophysics, 2008
The resorbing osteoclast is an exceptional cell that secretes large amounts of acid through the coupled activity of a v-type H+-ATPase and a chloride channel that both reside in the ruffled membrane. Impairment of this acid secretion machinery by genetic mutations can abolish bone resorption activity, resulting in osteopetrotic phenotypes.
Uwe Kornak, Uwe Kornak, Chayarop Supanchart   +2 more
openaire   +4 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Transport in the tokamak - reactor edge plasma with strong collisionality

Nuclear Materials and Energy, 2022
In detached divertor regimes, especially in future tokamak-reactors, plasma in the divertor is strongly collisional. When ion-ion and ion-neutral collision frequencies become comparable with the ion gyrofrequency, plasma transport is strongly affected by
V. Rozhansky, E. Kaveeva, I. Baranovsky, R.A. Pitts   +3 more
doaj  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source