Results 1 to 10 of about 71 (66)

Mikromolare Affinität und höher: synthetische Wirt‐Gast‐Komplexe mit hoher Stabilität

Angewandte Chemie, Volume 135, Issue 28, July 10, 2023., 2023
Dieser Aufsatz sammelt die jüngsten Errungenschaften bei der Gestaltung von 1 : 1‐Wirt‐Gast‐Komplexen mit Bindungskonstanten, die 106 M−1 überschreiten. Die Beziehungen zwischen den gemessenen thermodynamischen Konstanten und den Strukturparametern der interagierenden Spezies werden analysiert.
Sayan Sarkar, Pablo Ballester, Mark Spektor, Evgeny A. Kataev   +3 more
wiley   +1 more source

Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling

Medicinal Research Reviews, Volume 43, Issue 3, Page 614-682, May 2023., 2023
Abstract Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight cancer and overcome drug resistance in antitumor therapy. Understanding the molecular interactions and structural features of ferroptosis‐inducing compounds might ...
Solveigh C. Koeberle, Anna P. Kipp, Hermann Stuppner, Andreas Koeberle   +3 more
wiley   +1 more source

Single‐cell analyses reveal phosphate availability as critical factor for nutrition of Salmonella enterica within mammalian host cells

Cellular Microbiology, Volume 23, Issue 10, October 2021., 2021
Salmonella strains were engineered to report, on level of single intracellular bacteria, their intracellular niche and the availability of inorganic phosphate (Pi). In the Salmonella‐containing vacuole (SCV), Pi is limited and limitation increases with bacterial proliferation.
Jennifer Röder, Pascal Felgner, Michael Hensel   +2 more
wiley   +1 more source

Antiprotozoische Struktur‐Aktivitäts‐Beziehungen von synthetischen Leucinostatin‐Derivaten und Aufklärung ihres Wirkprinzips

Angewandte Chemie, Volume 133, Issue 28, Page 15741-15749, July 5, 2021., 2021
Eine Struktur‐Aktivitäts‐Beziehung des Naturstoffs Leucinostatin A führte zu zwei hochpotenten Verbindungen gegen das Protozoon Trypanosoma brucei mit verminderter toxischer Wirkung in vitro und in vivo. Diese Verbindungen bildeten keine Resistenzen bei langzeitiger subletaler Exposition und ihr Wirkmechanismus liegt in der Destabilisierung der inneren
Michael Brand, Lei Wang, Stefano Agnello, Silvia Gazzola, Flavio M. Gall, Luka Raguž, Marcel Kaiser, Remo S. Schmidt, Amélie Ritschl, Jennifer Jelk, Andrew Hemphill, Pascal Mäser, Peter Bütikofer, Michael Adams, Rainer Riedl   +14 more
wiley   +1 more source

Silacrown ionophores [PDF]

Journal of Membrane Science, 1987
A study is reported on the metal ion transport efficiency of various silacrown ether ionophores and their ethyleneoxy glycol hydrolysis products. The silacrowns are modified crown ethers in which an ethylene bridge has been replaced by a difunctional silyl group, e.g. dimethylsilyl.
Keith H. Pannell, Edna Rico, Cindy La Neave, Kamyar Rahimian, Alberto Amaya, Barry Arkles   +5 more
openaire   +2 more sources

A Na+ A1AO ATP synthase with a V‐type c subunit in a mesophilic bacterium

The FEBS Journal, Volume 287, Issue 14, Page 3012-3023, July 2020., 2020
In this study, the A1AO ATP synthase with a V‐type c subunit from the mesophilic acetogen Eubacterium limosum was purified. After incorporation of the enzyme into liposomes, ATP‐dependent primary transport of 22Na+ could be demonstrated. The ATP synthase from E. limosum is the first with a V‐type c subunit from a mesophilic organism.
Dennis Litty, Volker Müller
wiley   +1 more source

Cytotoxicity Assay for Detection of Cereulide Produced by Emetic Bacillus cereus

Bio-Protocol, 2013
The emetic subgroup of Bacillus cereus strains produces cereulide, a dodecadepsipeptide (1.2 kDa), which is the causative agent of food poisonings. Cereulide is synthesized by a nonribosomal peptide synthetase (NRPS), the Ces-NRPS (Ehling-Schulz et al ...
Elrike Frenzel , Monika Ehling-Schulz
doaj   +1 more source

Desenvolvimento de novilhas de corte sob alternativas de mineralização em pastagem de azevém Development of beef heifers under mineralization alternatives, on Italian ryegrass pasture

Ciência Rural, 2009
Foi avaliado o desenvolvimento corporal de bezerras de corte em pastagem de azevém (Lolium multiflorum Lam.), recebendo diferentes alternativas de suplementação mineral, associadas ou não à adição de ionóforo.
Luciana Pötter, Marta Gomes da Rocha, Alexandre Nunes Motta de Souza, Dalton Roso, Carine Lisete Glienke, Vagner Guasso da Costa, Renato Alves de Oliveira Neto, Gustavo Freitas Ilha   +7 more
doaj   +1 more source

Suplementação associada com lasalocida para novilhos em terminação em pastagem cultivada de inverno Supplementation associated with lasalocid for finishing beef steers on cultivated winter pasture

Ciência Rural, 1999
O experimento teve como objetivo avaliar o ganho de peso na fase de terminação de novilhos de corte com peso médio inicial de 357± 15kg e idade média de 24 meses, suplementados em pastagem de aveia preta + azevém, com um resíduo médio de 2356kg MS/
João Restle, André Brugnara Soares, Marcus Vinícius Back Ferreira, Ivan Luiz Brondani, Katia Gobatti Calça   +4 more
doaj   +1 more source

Efeito da monensina sódica sobre a produção e composição do leite, a produção de mozzarela e o escore de condição corporal de búfalas Murrah Effect of monensin on milk production and composition, production of mozzarela cheese and body condition score of Murrah Buffalo cows

Revista Brasileira de Zootecnia, 2005
Avaliou-se o efeito da adição de monensina sódica sobre a produção, composição do leite, produção de mozzarela e o escore de condição corporal de búfalas da raça Murrah. O experimento foi conduzido na Área de Produção de Bubalinos da UNESP- FMVZ Botucatu/
Cristiana Andrighetto, André Mendes Jorge, Maria Isabel Franchi Vasconcellos Gomes, Amanda Hoch, Adriana Piccinin   +4 more
doaj   +1 more source