Results 11 to 20 of about 243 (133)

Ferroptosis-modulating small molecules for targeting drug-resistant cancer: Challenges and opportunities in manipulating redox signaling. [PDF]

Med Res Rev, 2023
Abstract Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight cancer and overcome drug resistance in antitumor therapy. Understanding the molecular interactions and structural features of ferroptosis‐inducing compounds might ...
Koeberle SC, Kipp AP, Stuppner H, Koeberle A.   +3 more
europepmc   +2 more sources

Mikromolare Affinität und höher: synthetische Wirt‐Gast‐Komplexe mit hoher Stabilität

Angewandte Chemie, Volume 135, Issue 28, July 10, 2023., 2023
Dieser Aufsatz sammelt die jüngsten Errungenschaften bei der Gestaltung von 1 : 1‐Wirt‐Gast‐Komplexen mit Bindungskonstanten, die 106 M−1 überschreiten. Die Beziehungen zwischen den gemessenen thermodynamischen Konstanten und den Strukturparametern der interagierenden Spezies werden analysiert.
Sayan Sarkar, Pablo Ballester, Mark Spektor, Evgeny A. Kataev   +3 more
wiley   +1 more source

Single‐cell analyses reveal phosphate availability as critical factor for nutrition of Salmonella enterica within mammalian host cells

Cellular Microbiology, Volume 23, Issue 10, October 2021., 2021
Salmonella strains were engineered to report, on level of single intracellular bacteria, their intracellular niche and the availability of inorganic phosphate (Pi). In the Salmonella‐containing vacuole (SCV), Pi is limited and limitation increases with bacterial proliferation.
Jennifer Röder, Pascal Felgner, Michael Hensel   +2 more
wiley   +1 more source

Antiprotozoische Struktur‐Aktivitäts‐Beziehungen von synthetischen Leucinostatin‐Derivaten und Aufklärung ihres Wirkprinzips

Angewandte Chemie, Volume 133, Issue 28, Page 15741-15749, July 5, 2021., 2021
Eine Struktur‐Aktivitäts‐Beziehung des Naturstoffs Leucinostatin A führte zu zwei hochpotenten Verbindungen gegen das Protozoon Trypanosoma brucei mit verminderter toxischer Wirkung in vitro und in vivo. Diese Verbindungen bildeten keine Resistenzen bei langzeitiger subletaler Exposition und ihr Wirkmechanismus liegt in der Destabilisierung der inneren
Michael Brand, Lei Wang, Stefano Agnello, Silvia Gazzola, Flavio M. Gall, Luka Raguž, Marcel Kaiser, Remo S. Schmidt, Amélie Ritschl, Jennifer Jelk, Andrew Hemphill, Pascal Mäser, Peter Bütikofer, Michael Adams, Rainer Riedl   +14 more
wiley   +1 more source

Impact of wines and wine constituents on cyclooxygenase-1, cyclooxygenase-2, and 5-lipoxygenase catalytic activity. [PDF]

Mediators Inflamm, 2014
Cyclooxygenases and lipoxygenases are proinflammatory enzymes; the former affects platelet aggregation, vasoconstriction, vasodilatation and later the development of atherosclerosis. Red wines from Georgia and central and western Europe inhibited cyclooxygenase‐1 (COX‐1) activity in the range of 63–94%, cyclooxygenase‐2 (COX‐2) activity in the range of
Kutil Z, Temml V, Maghradze D, Pribylova M, Dvorakova M, Schuster D, Schuster D, Vanek T, Landa P.   +8 more
europepmc   +2 more sources

A Na+ A1AO ATP synthase with a V‐type c subunit in a mesophilic bacterium

The FEBS Journal, Volume 287, Issue 14, Page 3012-3023, July 2020., 2020
In this study, the A1AO ATP synthase with a V‐type c subunit from the mesophilic acetogen Eubacterium limosum was purified. After incorporation of the enzyme into liposomes, ATP‐dependent primary transport of 22Na+ could be demonstrated. The ATP synthase from E. limosum is the first with a V‐type c subunit from a mesophilic organism.
Dennis Litty, Volker Müller
wiley   +1 more source

EFEITO DA MONENSINA SÓDICA SOBRE O PERFIL METABÓLICO DE OVELHAS ANTES E APÓS O PARTO

Ciência Animal Brasileira, 2016
The study was carried out to analyze the effect of monensin supplementation during 60 days prior to parturition, and 30 days postpartum, on the metabolic and hormonal profile of ewes.
Elizabeth Hortêncio Ferreira Lima, Carla Lopes Mendonça, Jobson Filipe de Paula Cajueiro, Cleyton Charles Dantas Carvalho, Pierre Castro Soares, Rodolfo José Cavalcanti Souto, Ana Rita Fraga Drummond, José Augusto Bastos Afonso   +7 more
doaj   +1 more source

How Sleep Activates Epileptic Networks?

Epilepsy Research and Treatment, Volume 2013, Issue 1, 2013., 2013
Background. The relationship between sleep and epilepsy has been long ago studied, and several excellent reviews are available. However, recent development in sleep research, the network concept in epilepsy, and the recognition of high frequency oscillations in epilepsy and more new results may put this matter in a new light. Aim.
Peter Halász, Enrica Bonanni
wiley   +1 more source

Salinomycin as a Drug for Targeting Human Cancer Stem Cells

BioMed Research International, Volume 2012, Issue 1, 2012., 2012
Cancer stem cells (CSCs) represent a subpopulation of tumor cells that possess self‐renewal and tumor initiation capacity and the ability to give rise to the heterogenous lineages of malignant cells that comprise a tumor. CSCs possess multiple intrinsic mechanisms of resistance to chemotherapeutic drugs, novel tumor‐targeted drugs, and radiation ...
Cord Naujokat, Roman Steinhart, Adam Huczynski   +2 more
wiley   +1 more source

Selective Transport of Silver(I) Ion Through Polymer Membranes Containing Thioether Donor Macrocycles as Carriers

Journal of Chemistry, Volume 5, Issue 2, Page 271-274, 2008., 2008
The Preparation of polymer membrane and it′s selectivity to silver(I) ion from an aqueous solution containing seven metal cations, Co(II), Ni(II), Cu(II), Zn(II), Ag(I), Cd(II) and Pb(II), was studied. The source phase contained equimolar concentrations of the above mentioned cations with the source and receiving phases being buffered at pH 5.0 and 3.0
A. Nezhadali, M. Akbarpour
wiley   +1 more source