Results 151 to 160 of about 59,051 (256)

Deficiency of Tissue Nonspecific Alkaline Phosphatase Dysregulates Microglial Morphology and Function in a Mouse Model of Infantile Hypophosphatasia

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Using male and female tissue‐nonspecific alkaline phosphatase (TNAP) knockout (KO) and wild type (WT) mice, we show TNAP loss impairs growth and sensorimotor function and induces marked microglial morphological changes (enlarged soma, retracted processes).
Kareem Elaswad, Yara Mashal, Iyah Nasser, Linna Almhanaa, Chloe Grabowski, Zhi Zhang   +5 more
wiley   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Ionotropic Receptor 76b Is Required for Gustatory Aversion to Excessive Na+ in Drosophila. [PDF]

Mol Cells, 2017
Lee MJ, Sung HY, Jo H, Kim HW, Choi MS, Kwon JY, Kang K.   +6 more
europepmc   +1 more source

The power of ionic movements in plants

New Phytologist, Volume 249, Issue 5, Page 2232-2240, March 2026.
Summary The movement of ion‐driven electrogenic events known as plant action potentials in the Venus flytrap Dionaea muscipula has first been recognized in Darwin's time. Besides electrophysiological techniques making use of current‐ and voltage‐recording electrodes, today an ever‐growing spectrum of tools has become available, that report online ...
Rainer Hedrich, Ines Kreuzer
wiley   +1 more source

Glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) gene polymorphism (rs4998386) and Parkinson's disease susceptibility: A meta-analysis. [PDF]

Aging Med (Milton), 2019
Nepal G, Rehrig JH, Ojha R.
europepmc   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, Volume 80, Issue 3, Page 166-179, March 2026.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Ca²⁺ flux through splice variants of the ATP-gated ionotropic receptor P2X7 is regulated by its cytoplasmic N terminus. [PDF]

J Biol Chem, 2019
Liang X, Samways DSK, Cox J, Egan TM.
europepmc   +1 more source

Promotion of lung cancer growth via glutamate ionotropic receptor N-methyl-D-aspartate-type subunit 2D (<i>GRIN2D</i>). [PDF]

J Thorac Dis
Lv Y, Bu X, Du Z, Zhang Y, Si Y, Shi H, Han L, Bao H.   +7 more
europepmc   +1 more source

P2X7 ionotropic receptor is functionally expressed in rabbit articular chondrocytes and mediates extracellular ATP cytotoxicity. [PDF]

Purinergic Signal, 2018
Tanigawa H, Toyoda F, Kumagai K, Okumura N, Maeda T, Matsuura H, Imai S.   +6 more
europepmc   +1 more source

Ionotropic Receptor Genes in Fig Wasps: Evolutionary Insights from Comparative Studies. [PDF]

Insects
Yu H, Nong X, Huang W, Yang L, Bhanumas C, Xiong Y, Dai S.   +6 more
europepmc   +1 more source