Results 31 to 40 of about 59,051 (256)

Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease

open access: yesNeurobiology of Disease, 2006
We compared the neuroprotective and metabolic effects of chronic treatment with ionotropic or metabotropic glutamate receptor antagonists, in rats bearing a unilateral nigrostriatal lesion induced by 6-hydroxydopamine (6-OHDA). The ionotropic, N-methyl-d-
Marie-Thérèse Armentero   +4 more
doaj   +1 more source

Insect odorant response sensitivity is tuned by metabotropically autoregulated olfactory receptors. [PDF]

open access: yesPLoS ONE, 2013
Insects possess one of the most exquisitely sensitive olfactory systems in the animal kingdom, consisting of three different types of chemosensory receptors: ionotropic glutamate-like receptors (IRs), gustatory receptors (GRs) and odorant receptors (ORs).
Merid N Getahun   +4 more
doaj   +1 more source

De novo assembly of the freshwater prawn Macrobrachium carcinus brain transcriptome for identification of potential targets for antibody development.

open access: yesPLoS ONE, 2021
Crustaceans are major constituents of aquatic ecosystems and, as such, changes in their behavior and the structure and function of their bodies can serve as indicators of alterations in their immediate environment, such as those associated with climate ...
Jonathan L Crooke-Rosado   +4 more
doaj   +1 more source

Emerging key roles for P2X receptors in the kidney [PDF]

open access: yes, 2013
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E.   +3 more
core   +2 more sources

Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]

open access: yes, 2017
The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
core   +3 more sources

The voltage-gated potassium channel Shaker promotes sleep via thermosensitive GABA transmission [PDF]

open access: yes, 2020
Genes and neural circuits coordinately regulate animal sleep. However, it remains elusive how these endogenous factors shape sleep upon environmental changes.
Baik, Bukyung   +7 more
core   +1 more source

Undifferentiated embryonic stem cells express ionotropic glutamate receptor mRNAs

open access: yesFrontiers in Cellular Neuroscience, 2013
Ionotropic glutamate receptors (iGluRs) do not only mediate the majority of excitatory neurotransmission in the vertebrate CNS, but also modulate pre- and postnatal neurogenesis.
Svenja ePachernegg   +31 more
doaj   +1 more source

Identification and Expression Profile of Olfactory Receptor Genes Based on Apriona germari (Hope) Antennal Transcriptome

open access: yesFrontiers in Physiology, 2020
Insects’ olfactory receptor plays a central role in detecting chemosensory information from the environment. Odorant receptors (ORs) and ionotropic receptors (IRs) are two types of olfactory receptors, and they are essential for the recognition of ...
Jia-Li Qian   +8 more
doaj   +1 more source

ATP as a presynaptic modulator [PDF]

open access: yes, 2000
© 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core   +1 more source

Tuning Insect Odorant Receptors

open access: yesFrontiers in Cellular Neuroscience, 2018
Among the insect olfactory receptors the odorant receptors (ORs) evolved in parallel to the onset of insect flight. A special property of this receptor type is the capability to adjust sensitivity of odor detection according to previous odor contacts ...
Dieter Wicher
doaj   +1 more source

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