Results 21 to 30 of about 59,355 (255)

Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons

open access: yeseLife, 2021
Summation of ionotropic receptor-mediated responses is critical in neuronal computation by shaping input-output characteristics of neurons. However, arithmetics of summation for metabotropic signals are not known. We characterized the combined ionotropic
Attila Ozsvár   +5 more
doaj   +1 more source

ATP as a presynaptic modulator [PDF]

open access: yes, 2000
© 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core   +1 more source

A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury

open access: yesScientific Reports, 2017
NMDA receptor (NMDAR) is known for its ionotropic function. But recent evidence suggests that NMDAR also has a non-ionotropic property. To determine the role of non-ionotropic activity of NMDARs in clinical relevant conditions, we tested the effect of ...
Juan Chen   +10 more
doaj   +1 more source

P2X receptor trafficking in neurons is subunit specific [PDF]

open access: yes, 2002
P2X receptors within the CNS mediate excitatory synaptic transmission and also act presynaptically to modulate neurotransmitter release. We have studied the targeting and trafficking of P2X4 and P2X2 receptors heterologously expressed in cultured ...
Bobanovic, Laura K   +2 more
core   +3 more sources

In situ tip-recordings found no evidence for an Orco-based ionotropic mechanism of pheromone-transduction in Manduca sexta. [PDF]

open access: yesPLoS ONE, 2013
The mechanisms of insect odor transduction are still controversial. Insect odorant receptors (ORs) are 7TM receptors with inverted membrane topology. They colocalize with a conserved coreceptor (Orco) with chaperone and ion channel function. Some studies
Andreas Nolte   +7 more
doaj   +1 more source

Candidate chemosensory receptors in the antennae and maxillae of Spodoptera frugiperda (J. E. Smith) larvae

open access: yesFrontiers in Physiology, 2022
Although most of the damage caused by lepidopteran insects to plants is caused by the larval stage, chemosensory systems have been investigated much more frequently for lepidopteran adults than for larvae. The fall armyworm Spodoptera frugiperda (J.
Ya-Lan Sun   +4 more
doaj   +1 more source

Rapid evolution of chemosensory receptor genes in a pair of sibling species of orchid bees (Apidae: Euglossini). [PDF]

open access: yes, 2015
BackgroundInsects rely more on chemical signals (semiochemicals) than on any other sensory modality to find, identify, and choose mates. In most insects, pheromone production is typically regulated through biosynthetic pathways, whereas pheromone sensory
Brand, Philipp   +5 more
core   +3 more sources

Chemoreceptor proteins in the Caribbean spiny lobster, Panulirus argus: Expression of Ionotropic Receptors, Gustatory Receptors, and TRP channels in two chemosensory organs and brain. [PDF]

open access: yesPLoS ONE, 2018
The spiny lobster, Panulirus argus, has two classes of chemosensilla representing "olfaction" and "distributed chemoreception," as is typical for decapod crustaceans.
Mihika T Kozma   +5 more
doaj   +1 more source

Negative modulation of the GABAAρ1 receptor function by l-cysteine [PDF]

open access: yes, 2017
l-Cysteine is an endogenous sulfur-containing amino acid with multiple and varied roles in the central nervous system, including neuroprotection and the maintenance of the redox balance.
Beltrán González, Andrea Natalia   +2 more
core   +1 more source

When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer's Disease. [PDF]

open access: yes, 2016
Alzheimer\u2019s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists\u2019 attention because of its complexity.
AGOSTINI, MARIO, FASOLATO, CRISTINA
core   +1 more source

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