Results 21 to 30 of about 35,320 (207)

Non-ionotropic signaling by the NMDA receptor: controversy and opportunity [version 1; referees: 2 approved]

F1000Research, 2016
Provocative emerging evidence suggests that the N-methyl-D-aspartate (NMDA) receptor can signal in the absence of ion flux through the receptor. This non-ionotropic signaling is thought to be due to agonist-induced conformational changes in the receptor,
John A. Gray, Karen Zito, Johannes W. Hell   +2 more
doaj   +1 more source

Presynaptic ionotropic receptors

Current Opinion in Neurobiology, 1996
Recent studies have provided new insights into the role of presynaptic ligand-gated ion channels in modifying synaptic transmission. Along with a growing list of different types of presynaptic ionotropic receptors and the cell types that express them, there have been advances in characterizing the molecular components of the receptors as well as the ...
D S, McGehee, L W, Role
openaire   +2 more sources

Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics

Frontiers in Cellular Neuroscience, 2014
The central nucleus of amygdala (CeA) has a role for mediating fear and anxiety responses. It is also involved in emotional imbalance caused by alcohol abuse and dependence and in regulating relapse to alcohol abuse.
Zhe eJin, Amol K Bhandage, Igor eBazov, Olga eKononenko, Georgy eBakalkin, Esa R Korpi, Bryndis eBirnir   +6 more
doaj   +1 more source

More than meets the IR: the expanding roles of variant Ionotropic Glutamate Receptors in sensing odor, taste, temperature and moisture [version 1; referees: 2 approved]

F1000Research, 2017
The ionotropic receptors (IRs) are a branch of the ionotropic glutamate receptor family and serve as important mediators of sensory transduction in invertebrates.
Lena van Giesen, Paul A. Garrity
doaj   +1 more source

Comparison of transcriptomes from two chemosensory organs in four decapod crustaceans reveals hundreds of candidate chemoreceptor proteins.

PLoS ONE, 2020
Crustaceans express genes for at least three classes of putative chemosensory proteins. These are: Ionotropic Receptors (IRs), derived from the heterotetrameric ionotropic glutamate receptors (iGluRs); Transient Receptor Potential (TRP) channels, a ...
Mihika T Kozma, Hanh Ngo-Vu, Yuen Yan Wong, Neal S Shukla, Shrikant D Pawar, Adriano Senatore, Manfred Schmidt, Charles D Derby   +7 more
doaj   +1 more source

Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual system. [PDF]

PLoS ONE, 2008
Synaptic connections of neurons in the Drosophila lamina, the most peripheral synaptic region of the visual system, have been comprehensively described.
Agata Kolodziejczyk, Xuejun Sun, Ian A Meinertzhagen, Dick R Nässel   +3 more
doaj   +1 more source

Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons

eLife, 2021
Summation of ionotropic receptor-mediated responses is critical in neuronal computation by shaping input-output characteristics of neurons. However, arithmetics of summation for metabotropic signals are not known. We characterized the combined ionotropic
Attila Ozsvár, Gergely Komlósi, Gáspár Oláh, Judith Baka, Gábor Molnár, Gábor Tamás   +5 more
doaj   +1 more source

A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury

Scientific Reports, 2017
NMDA receptor (NMDAR) is known for its ionotropic function. But recent evidence suggests that NMDAR also has a non-ionotropic property. To determine the role of non-ionotropic activity of NMDARs in clinical relevant conditions, we tested the effect of ...
Juan Chen, Rong Hu, Huabao Liao, Ya Zhang, Ruixue Lei, Zhifeng Zhang, Yang Zhuang, Yu Wan, Ping Jin, Hua Feng, Qi Wan   +10 more
doaj   +1 more source

In situ tip-recordings found no evidence for an Orco-based ionotropic mechanism of pheromone-transduction in Manduca sexta. [PDF]

PLoS ONE, 2013
The mechanisms of insect odor transduction are still controversial. Insect odorant receptors (ORs) are 7TM receptors with inverted membrane topology. They colocalize with a conserved coreceptor (Orco) with chaperone and ion channel function. Some studies
Andreas Nolte, Nico W Funk, Latha Mukunda, Petra Gawalek, Achim Werckenthin, Bill S Hansson, Dieter Wicher, Monika Stengl   +7 more
doaj   +1 more source

Candidate chemosensory receptors in the antennae and maxillae of Spodoptera frugiperda (J. E. Smith) larvae

Frontiers in Physiology, 2022
Although most of the damage caused by lepidopteran insects to plants is caused by the larval stage, chemosensory systems have been investigated much more frequently for lepidopteran adults than for larvae. The fall armyworm Spodoptera frugiperda (J.
Ya-Lan Sun, Peng-Shuo Jiang, Bing-Xin Dong, Cai-Hong Tian, Jun-Feng Dong   +4 more
doaj   +1 more source