Results 11 to 20 of about 1,272,062 (259)

Non-ionotropic signaling by the NMDA receptor: controversy and opportunity [version 1; referees: 2 approved] [PDF]

F1000Research, 2016
Provocative emerging evidence suggests that the N-methyl-D-aspartate (NMDA) receptor can signal in the absence of ion flux through the receptor. This non-ionotropic signaling is thought to be due to agonist-induced conformational changes in the receptor,
John A. Gray, Karen Zito, Johannes W. Hell   +2 more
doaj   +2 more sources

GluD1 is a signal transduction device disguised as an ionotropic receptor. [PDF]

Nature, 2021
Ionotropic glutamate delta receptors 1 (GluD1) and 2 (GluD2) exhibit the molecular architecture of postsynaptic ionotropic glutamate receptors, but assemble into trans-synaptic adhesion complexes by binding to secreted cerebellins that in turn interact ...
Dai J, Patzke C, Liakath-Ali K, Seigneur E, Südhof TC.   +4 more
europepmc   +2 more sources

Ionotropic glutamate receptor AMPA 1 is associated with ovulation rate.

PLoS ONE, 2010
Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central nervous system by opening ion channels upon the binding of glutamate.
Mayumi Sugimoto, Shinji Sasaki, Toshio Watanabe, Shota Nishimura, Atsushi Ideta, Maya Yamazaki, Keiko Matsuda, Michisuke Yuzaki, Kenji Sakimura, Yoshito Aoyagi, Yoshikazu Sugimoto   +10 more
doaj   +2 more sources

DNA Methylation Signature of Epileptic Encephalopathy-Related Pathogenic Genes Encoding Ion Channels in Temporal Lobe Epilepsy

Frontiers in Neurology, 2021
Epilepsy is characterized by highly abnormal synchronous discharge of brain neurons, and ion channels are fundamental in the generation and modulation of neural excitability.
Hua Tao, Hua Tao, Zengqiang Chen, Jianhao Wu, Jun Chen, Yusen Chen, Jiawu Fu, Chaowen Sun, Haihong Zhou, Wangtao Zhong, Xu Zhou, Xu Zhou, Keshen Li, Keshen Li   +13 more
doaj   +1 more source

Ionotropic and metabotropic responses by alpha 7 nicotinic acetylcholine receptors

Pharmacological Research, 2023
Nicotinic acetylcholine receptors (nAChRs) belong to a superfamily of cys-loop receptors characterized by the assembly of five subunits into a multi-protein channel complex.
Patricia Sinclair, Nadine Kabbani
doaj   +1 more source

Presynaptic ionotropic receptors

Current Opinion in Neurobiology, 1996
Recent studies have provided new insights into the role of presynaptic ligand-gated ion channels in modifying synaptic transmission. Along with a growing list of different types of presynaptic ionotropic receptors and the cell types that express them, there have been advances in characterizing the molecular components of the receptors as well as the ...
D S, McGehee, L W, Role
openaire   +2 more sources

Age-dependent remodelling of ionotropic signalling in cortical astroglia [PDF]

, 2011
Cortical astrocytes express fast ionotropic receptors for glutamate and ATP, although their role in neurone-glia communication remains controversial.
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Verkhratsky, Alexei, Oleg Palygin, Ulyana Lalo, North, Richard Alan, Richard Alan North, Yuriy Pankratov, North, R. Alan, Verkhratsky, Alexei; id_orcid, Alexei Verkhratsky   +11 more
core   +1 more source

More than meets the IR: the expanding roles of variant Ionotropic Glutamate Receptors in sensing odor, taste, temperature and moisture [version 1; referees: 2 approved]

F1000Research, 2017
The ionotropic receptors (IRs) are a branch of the ionotropic glutamate receptor family and serve as important mediators of sensory transduction in invertebrates.
Lena van Giesen, Paul A. Garrity
doaj   +1 more source

Comparison of transcriptomes from two chemosensory organs in four decapod crustaceans reveals hundreds of candidate chemoreceptor proteins.

PLoS ONE, 2020
Crustaceans express genes for at least three classes of putative chemosensory proteins. These are: Ionotropic Receptors (IRs), derived from the heterotetrameric ionotropic glutamate receptors (iGluRs); Transient Receptor Potential (TRP) channels, a ...
Mihika T Kozma, Hanh Ngo-Vu, Yuen Yan Wong, Neal S Shukla, Shrikant D Pawar, Adriano Senatore, Manfred Schmidt, Charles D Derby   +7 more
doaj   +1 more source

A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury

Scientific Reports, 2017
NMDA receptor (NMDAR) is known for its ionotropic function. But recent evidence suggests that NMDAR also has a non-ionotropic property. To determine the role of non-ionotropic activity of NMDARs in clinical relevant conditions, we tested the effect of ...
Juan Chen, Rong Hu, Huabao Liao, Ya Zhang, Ruixue Lei, Zhifeng Zhang, Yang Zhuang, Yu Wan, Ping Jin, Hua Feng, Qi Wan   +10 more
doaj   +1 more source