Results 31 to 40 of about 33,342 (190)

Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity

Neural Plasticity, 2011
Throughout life, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience. In line with predictions made by Hebb, synapse strength can be modified depending on the millisecond ...
Matthijs B. Verhoog, Huibert D. Mansvelder   +1 more
doaj   +1 more source

Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CPG

Frontiers in Neural Circuits, 2010
Locomotion is a fundamental motor act that, to a large degree, is controlled by central pattern generating (CPG) networks in the spinal cord. Glutamate is thought to be responsible for most of the excitatory input to and the excitatory activity within ...
Adolfo E Talpalar, Ole Kiehn
doaj   +1 more source

Identification of Candidate Chemosensory Receptors in the Antennae of the Variegated Cutworm, Peridroma saucia Hübner, Based on a Transcriptome Analysis

Frontiers in Physiology, 2020
Insect chemoreception, including olfaction and gustation, involves several families of genes, including odorant receptors (ORs), ionotropic receptors (IRs), and gustatory receptors (GRs).
Ya-Lan Sun, Jun-Feng Dong, Nan Gu, Shao-Li Wang   +3 more
doaj   +1 more source

More than meets the IR: the expanding roles of variant Ionotropic Glutamate Receptors in sensing odor, taste, temperature and moisture [version 1; referees: 2 approved]

F1000Research, 2017
The ionotropic receptors (IRs) are a branch of the ionotropic glutamate receptor family and serve as important mediators of sensory transduction in invertebrates.
Lena van Giesen, Paul A. Garrity
doaj   +1 more source

Ligands for Ionotropic Glutamate Receptors [PDF]

, 2009
Marine-derived small molecules and peptides have played a central role in elaborating pharmacological specificities and neuronal functions of mammalian ionotropic glutamate receptors (iGluRs), the primary mediators of excitatory synaptic transmission in the central nervous system (CNS).
Geoffrey T, Swanson, Ryuichi, Sakai
openaire   +2 more sources

Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila

eLife, 2016
Ionotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these receptors are most extensively studied for their roles in chemosensory detection, recent work has implicated two family ...
Zachary A Knecht, Ana F Silbering, Lina Ni, Mason Klein, Gonzalo Budelli, Rati Bell, Liliane Abuin, Anggie J Ferrer, Aravinthan DT Samuel, Richard Benton, Paul A Garrity   +10 more
doaj   +1 more source

De novo assembly of the freshwater prawn Macrobrachium carcinus brain transcriptome for identification of potential targets for antibody development.

PLoS ONE, 2021
Crustaceans are major constituents of aquatic ecosystems and, as such, changes in their behavior and the structure and function of their bodies can serve as indicators of alterations in their immediate environment, such as those associated with climate ...
Jonathan L Crooke-Rosado, Sara C Diaz-Mendez, Yamil E Claudio-Roman, Nilsa M Rivera, Maria A Sosa   +4 more
doaj   +1 more source

Assembly Stoichiometry of the GluK2/GluK5 Kainate Receptor Complex

Cell Reports, 2012
Ionotropic glutamate receptors assemble as homo- or heterotetramers. One well-studied heteromeric complex is formed by the kainate receptor subunits GluK2 and GluK5.
Andreas Reiner, Ryan J. Arant, Ehud Y. Isacoff   +2 more
doaj   +1 more source

A Review of Molecular Imaging of Glutamate Receptors

Molecules, 2020
Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) is a well-established and important in vivo technique to evaluate fundamental biological processes and unravel the role of neurotransmitter ...
Jong-Hoon Kim, János Marton, Simon Mensah Ametamey, Paul Cumming   +3 more
doaj   +1 more source

The Neuropeptide Nocistatin Is Not a Direct Agonist of Acid-Sensing Ion Channel 1a (ASIC1a)

Biomolecules, 2021
Acid-sensing ion channels (ASICs) are ionotropic receptors that are directly activated by protons. Although protons have been shown to act as a neurotransmitter and to activate ASICs during synaptic transmission, it remains a possibility that other ...
Sven Kuspiel, Dominik Wiemuth, Stefan Gründer   +2 more
doaj   +1 more source