A detailed study of the diastereoselective catalytic hydrogenation of 6-hydroxytetrahydroisoquinoline-(3R)-carboxylic ester intermediates [PDF]
, 2012 A key step towards a highly-selective antagonist of ionotropic glutamate receptors entails the diastereoselective arene hydrogenation of an enantiopure tetrahydroisoquinoline.
Ager, David J., +10 more
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A Review of Molecular Imaging of Glutamate Receptors
Molecules, 2020 Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) is a well-established and important in vivo technique to evaluate fundamental biological processes and unravel the role of neurotransmitter ...
Jong-Hoon Kim +3 more
doaj +1 more source
The Neuropeptide Nocistatin Is Not a Direct Agonist of Acid-Sensing Ion Channel 1a (ASIC1a)
Biomolecules, 2021 Acid-sensing ion channels (ASICs) are ionotropic receptors that are directly activated by protons. Although protons have been shown to act as a neurotransmitter and to activate ASICs during synaptic transmission, it remains a possibility that other ...
Sven Kuspiel +2 more
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Frontiers in Molecular BiosciencesIn insects, antennal ionotropic receptors (IRs) and odorant receptors (ORs) are among the main sensors of olfactory cues. To functionally characterize the subunits from these receptors, the use of ab3A neurons from transgenic Drosophila melanogaster ...
Johan Henning Pettersson +3 more
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Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. [PDF]
PLoS ONE, 2012 Recent studies suggest that l-glutamate may be an efferent transmitter released from axons innervating taste buds. In this report, we determined the types of ionotropic synaptic glutamate receptors present on taste cells and that underlie this postulated
Yijen A Huang, Jeff Grant, Stephen Roper
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elPBN neurons regulate rVLM activity through elPBN-rVLM projections during activation of cardiac sympathetic afferent nerves. [PDF]
, 2016 The external lateral parabrachial nucleus (elPBN) within the pons and rostral ventrolateral medulla (rVLM) contributes to central processing of excitatory cardiovascular reflexes during stimulation of cardiac sympathetic afferent nerves (CSAN).
Fu, Liang-Wu +3 more
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Avoiding alkaline taste through ionotropic receptors
iScienceSummary: Taste organs contain distinct gustatory receptors that help organisms differentiate between nourishing and potentially harmful foods. The detection of high pH levels plays a crucial role in food selection, but the specific gustatory receptors ...
Prakash Pandey +2 more
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Ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors
Frontiers in Molecular Neuroscience, 2015 Changes in synaptic strength underlie the basis of learning and memory and are controlled, in part, by the insertion or removal of AMPA-type glutamate receptors at the postsynaptic membrane of excitatory synapses.
Marisa S Goo +2 more
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Cells, 2021 The role of autoimmunity in central nervous system (CNS) disorders is rapidly expanding. In the last twenty years, different types of autoantibodies targeting subunits of ionotropic glutamate receptors have been found in a variety of patients affected by
Fabrizio Gardoni +5 more
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Transcriptional Profiles for Glutamate Transporters Reveal Differences Between Organophosphates but Similarities with Unrelated Neurotoxicants [PDF]
, 2010 The developmental neurotoxicity of organophosphates involves mechanisms other than their shared property as cholinesterase inhibitors, among which are excitotoxicity and oxidative stress.
Lobner, Doug +2 more
core +2 more sources