Results 41 to 50 of about 33,342 (190)

Heterologous investigation of metabotropic and ionotropic odorant receptors in ab3A neurons of Drosophila melanogaster

Frontiers in Molecular Biosciences
In insects, antennal ionotropic receptors (IRs) and odorant receptors (ORs) are among the main sensors of olfactory cues. To functionally characterize the subunits from these receptors, the use of ab3A neurons from transgenic Drosophila melanogaster ...
Johan Henning Pettersson, Alberto Maria Cattaneo, Alberto Maria Cattaneo, Alberto Maria Cattaneo   +3 more
doaj   +1 more source

Ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors

Frontiers in Molecular Neuroscience, 2015
Changes in synaptic strength underlie the basis of learning and memory and are controlled, in part, by the insertion or removal of AMPA-type glutamate receptors at the postsynaptic membrane of excitatory synapses.
Marisa S Goo, Samantha L Scudder, Gentry N Patrick   +2 more
doaj   +1 more source

Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. [PDF]

PLoS ONE, 2012
Recent studies suggest that l-glutamate may be an efferent transmitter released from axons innervating taste buds. In this report, we determined the types of ionotropic synaptic glutamate receptors present on taste cells and that underlie this postulated
Yijen A Huang, Jeff Grant, Stephen Roper
doaj   +1 more source

NMDA and AMPA Receptor Autoantibodies in Brain Disorders: From Molecular Mechanisms to Clinical Features

Cells, 2021
The role of autoimmunity in central nervous system (CNS) disorders is rapidly expanding. In the last twenty years, different types of autoantibodies targeting subunits of ionotropic glutamate receptors have been found in a variety of patients affected by
Fabrizio Gardoni, Jennifer Stanic, Diego Scheggia, Alberto Benussi, Barbara Borroni, Monica Di Luca   +5 more
doaj   +1 more source

Avoiding alkaline taste through ionotropic receptors

iScience
Summary: Taste organs contain distinct gustatory receptors that help organisms differentiate between nourishing and potentially harmful foods. The detection of high pH levels plays a crucial role in food selection, but the specific gustatory receptors ...
Prakash Pandey, Bhanu Shrestha, Youngseok Lee   +2 more
doaj   +1 more source

Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors

Brain Stimulation, 2023
Background: Focused ultrasound stimulation (FUS) has the potential to provide non-invasive neuromodulation of deep brain regions with unparalleled spatial precision.
Benjamin Clennell, Tom G.J. Steward, Kaliya Hanman, Tom Needham, Janette Benachour, Mark Jepson, Meg Elley, Nathan Halford, Kate Heesom, Eunju Shin, Elek Molnár, Bruce W. Drinkwater, Daniel J. Whitcomb   +12 more
doaj   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Sustainable Synaptic Device with Two‐Dimensional Ferroelectric Materials for Neuromorphic Computing

Advanced Science, EarlyView.
α‐In2Se3 based FeSFETs can be utilized as sustainable devices through polarization switching governed by both out‐of‐plane and in‐plane polarizations. Upon reaching a fatigued state, current annealing enabled by conductance modulation can significantly enhance the endurance of FeSFETs.
Jaewook Yoo, Seokjin Oh, Minah Park, Jong Min Song, Hongseung Lee, Seohyeon Park, Sojin Jung, Seongbin Lim, Soohyun Lim, Dongsun Shin, Ji Won Heo, TaeWan Kim, Hagyoul Bae   +12 more
wiley   +1 more source

Chronic glutamate toxicity in neurodegenerative diseases-what is the evidence?

Frontiers in Neuroscience, 2015
Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain. Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate receptors) and a class of G-protein coupled receptors (metabotropic glutamate ...
Pamela eMaher, Jan eLewerenz
doaj   +1 more source

Comparison of transcriptomes from two chemosensory organs in four decapod crustaceans reveals hundreds of candidate chemoreceptor proteins.

PLoS ONE, 2020
Crustaceans express genes for at least three classes of putative chemosensory proteins. These are: Ionotropic Receptors (IRs), derived from the heterotetrameric ionotropic glutamate receptors (iGluRs); Transient Receptor Potential (TRP) channels, a ...
Mihika T Kozma, Hanh Ngo-Vu, Yuen Yan Wong, Neal S Shukla, Shrikant D Pawar, Adriano Senatore, Manfred Schmidt, Charles D Derby   +7 more
doaj   +1 more source