Results 31 to 40 of about 761,438 (246)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Telomere-driven senescence accelerates tau pathology, neuroinflammation and neurodegeneration in a tauopathy mouse model

Acta Neuropathologica Communications
The connection between aging and neurodegenerative pathologies like Alzheimer’s disease (AD) has long been recognized, with senescent brain cells building up in the brains of AD patients.
Debora Palomares, Axelle A. T. Vanparys, Joana Jorgji, Esther Paître, Pascal Kienlen-Campard, Nuria Suelves   +5 more
doaj   +1 more source

Orange Sm:LiYF4 lasers emitting at 605 nm [PDF]

EPJ Web of Conferences
We report on polarized spectroscopy and orange laser operation under 2ω-OPSL and GaN-diode pumping of Sm:LiYF4 crystals. The Samarium laser delivers 12 mW at 605 nm with a threshold of 51 mW and a linear polarization.
Demaimay Jonathan, Loiko Pavel, Kifle Esrom, Pau Florence, Recoque Gilles, Benayad Abdelmjid, Georges Thierry, Camy Patrice, Braud Alain   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Gazing into spatiotemporal ‘known unknowns’: the influence of uncertainty on pupil size and saccadic eye movements

Scientific Reports
Expectation of a future stimulus increases the preparedness to act once it actually appears and results in reduced latency of the appropriate motor response.
Aïcha Boutachkourt, Dominika Drążyk, Marcus Missal   +2 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Neural representation of the musical beat is facilitated but not contingent on the repetition of rhythmic patterns

Scientific Reports
Music often entails perception of periodic beats which serve as internal temporal references to coordinate movements to music. Crucially, beat perception arises even in syncopated musical rhythms, which only weakly cue the beat periodicity.
Emmanuel Coulon, Sacha Baum, Tomas Lenc, Rainer Polak, Sylvie Nozaradan   +4 more
doaj   +1 more source

Neural substrates underlying motor skill learning in chronic hemiparetic stroke patients

Frontiers in Human Neuroscience, 2015
Motor skill learning is critical in post-stroke motor recovery, but little is known about its underlying neural substrates. Recently, using a new visuomotor skill learning paradigm involving a speed/accuracy trade-off in healthy individuals we identified
Stephanie eLefebvre, Stephanie eLefebvre, Laurence eDricot, Patrice eLaloux, Patrice eLaloux, wojciech eGradkowski, wojciech eGradkowski, Philippe eDesfontaines, Frédéric eEvrard, Andre ePeeters, Jacques eJamart, Yves eVandermeeren, Yves eVandermeeren, Yves eVandermeeren   +13 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source