Results 51 to 60 of about 761,438 (246)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Spectroscopy of low-phonon-energy Er:La2O2S oxysulfide [PDF]

EPJ Web of Conferences
Lanthanum oxysulfide powders doped with Erbium ions were fabricated by the combustion method followed by sulfurization at 1000 °C under H2S + N2 atmosphere. X-ray diffraction confirms their single-phase nature (sp. gr. P-3m1).
Poitou Marine, Normani Simone, Loiko Pavel, Braud Alain, Camy Patrice, Merdrignac-Conanec Odile   +5 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Vagal nerve signals are modulated by spontaneous seizures in Genetic Absence Epilepsy Rats from Strasbourg

Frontiers in Neuroscience
IntroductionOne-third of epileptic patients are resistant to conventional treatments. Vagus nerve stimulation is a promising therapy, especially when applied early during seizure onset.
Elise Collard, Enrique Germany Morrison, Enrique Germany Morrison, Elena Acedo Reina, Ayse S. Dereli, Auriane Apaire, Auriane Apaire, Antoine Nonclercq, Riem El Tahry, Riem El Tahry, Riem El Tahry   +10 more
doaj   +1 more source

Thermodynamic metal melting bases. Foundry production and metallurgy

Литьë и металлургия, 2020
Based on thermodynamic calculations, it is shown that metal melting is an equilibrium process that occurs at a constant temperature. In melting, microcrystals mainly disintegrate into nanocrystals.
E. I. Marukovich, V. Yu. Stetsenko
doaj   +1 more source

Ion channels and ion selectivity [PDF]

Essays in Biochemistry, 2017
Specific macromolecular transport systems, ion channels and pumps, provide the pathways to facilitate and control the passage of ions across the lipid membrane. Ion channels provide energetically favourable passage for ions to diffuse rapidly and passively according to their electrochemical potential.
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Thermodynamic metal crystallization basics

Литьë и металлургия, 2020
On the basis of thermodynamic calculations it is shown that crystallization of metals is a thermodynamic process, which takes place mainly at constant temperature.
E. I. Marukovich, V. Yu. Stetsenko
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Inhomogeneous spectral line broadening and site distribution in “mixed” Er:(Sc,Y)2O3 laser ceramics [PDF]

EPJ Web of Conferences
Erbium-doped “mixed” yttria-scandia (ScxY1-x)2O3 transparent laser ceramics were fabricated by vacuum sintering at 1750 °C from laser-ablated nanoparticles. Their absorption and mid-infrared emission properties were studied.
Normani Simone, Loiko Pavel, Maksimov Roman, Shitov Vladislav, Osipov Vladimir, Braud Alain, Camy Patrice   +6 more
doaj   +1 more source