Results 111 to 120 of about 41,736 (257)
Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
Visualization of IP3 Dynamics Reveals a Novel AMPA Receptor-Triggered IP3 Production Pathway Mediated by Voltage-Dependent Ca2+ Influx in Purkinje Cells [PDF]
, 2001 IP3 signaling in Purkinje cells is involved in the regulation of cell functions including LTD. We have used a GFP-tagged pleckstrin homology domain to visualize IP3 dynamics in Purkinje cells.
Iino, Masamitsu +3 more
core +1 more source
Two types of functionally distinct Ca2+ stores in hippocampal neurons
Nature Communications, 2019 It is generally assumed, from previous studies in cerebellar Purkinje neurons, that IP3 and Ry receptors share the same intracellular Ca2+ pool. In this study, the authors demonstrate the existence of two functionally distinct Ca2+ stores in mouse CA1 ...
Hsing-Jung Chen-Engerer +5 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley +1 more source
Cigarette Smoke Exposure Attenuates T2R‐Mediated Apoptosis in Head and Neck Squamous Cell Carcinoma
Head &Neck, Volume 48, Issue 10, Page 2745-2755, October 2026.ABSTRACT Background Tobacco use is associated with worse outcomes in head and neck squamous cell carcinoma (HNSCC). Bitter taste receptor (T2R) activation induces apoptosis via calcium‐dependent signaling, and higher T2R expression correlates with increased survival in HNSCC.
Kyle Polen +10 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.ABSTRACT Background Urolithin A (UA) and urolithin B (UB) are gut microbiota‐derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined.
Yves Henrotin +8 more
wiley +1 more source
, 1994 Cholecystokinin (CCK) and carbachol raise intracellular Ca2+ concentration ([Ca2+]i) in pancreatic acinar cells by elevating inositol 1,4,5-trisphosphate (IP3).
L. Sheu +3 more
core +1 more source
Conversion between permeability states of IP3 receptors in cultured smooth muscle cells
, 1995 The kinetics of the effect of inositol 1,4,5-trisphosphate (IP3) on Ca2+ in the sarcoplasmic reticulum (SR) were studied in saponin-permeabilized A7r5 cells.
T. Sugiyama, W. F. Goldman
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 19, Page 5832-5853, October 2026.Serotonin differentially modulates layer 5 mPFC microcircuits through cell type‐specific pre‐ and postsynaptic receptor pathways. Presynaptic 5‐HT1BRs suppress glutamate and GABA release, whereas presynaptic and postsynaptic 5‐HT3ARs enhance fast‐spiking interneuron activity, whilst distinct pyramidal neuron subtypes exhibit divergent 5‐HT1AR‐ and 5 ...
Ramya Rama +4 more
wiley +1 more source
IP3 receptors, IP3 transients, and nucleus-associated Ca2+ signals in cultured skeletal muscle [PDF]
, 2000 Inositol 1,4,5-trisphosphate (IP3) receptors (IP3R) and ryanodine receptors (RyR) were localized in cultured rodent muscle fractions by binding of radiolabeled ligands (IP3 and ryanodine), and IP3R were visualized in situ by fluorescence ...
Reyes, Roberto +3 more
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