针刺研究, 2008 Objective To observe the effect of electroacupuncture(EA)on inositol triphosphate(IP3)and diacylglycerol(DAG)contents in cerebral arteries of the cerebral cortex in rats with cerebral ischemia(CI),so as to explore its effect on intracellular signal ...
SUN Dong-wei +3 more
doaj
Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 9, September 2026.Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao +10 more
wiley +1 more source
Cryo-EM insights into isoform-specific properties of the IP<sub>3</sub>R2 channel. [PDF]
Nat CommunBaker MR +12 more
europepmc +1 more source
Molecular insights and translational opportunities to enhance heat tolerance in rice
The Plant Genome, Volume 19, Issue 3, September 2026.Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana +7 more
wiley +1 more source
From lipid dynamics to precision predictions: A new approach methodology for precision modeling of phosphoinositide signaling. [PDF]
J Precis Med (Amst)Hernandez-Hernandez G +6 more
europepmc +1 more source
Xanomeline and Trospium Chloride: Mechanism of Action, Clinical, and Translational Science
Clinical and Translational Science, Volume 19, Issue 9, September 2026.ABSTRACT Xanomeline‐trospium chloride (Cobenfy, formerly KarXT) is a first‐in‐class, oral central M1/M4 muscarinic receptor agonist approved for the treatment of schizophrenia in adults. Cobenfy represents a paradigm shift by avoiding direct dopamine D2 receptor blockade and thus significantly reduces the burden of metabolic, extrapyramidal, and ...
Samantha Avila, Ingrid L. Chen
wiley +1 more source
A multiscale PBPK-PD model of oxytocin-induced uterine excitation and contraction. [PDF]
J PhysiolYang Y +10 more
europepmc +1 more source
Exploring IP3-Ca2+ signaling by trapping intracellular IP3
Exploring IP3-Ca2+ signaling by trapping intracellular IP3学位論文の内容の要旨及び論文審査の結果の要旨 doctoral ...
openaire +1 more source
The FEBS Journal, Volume 293, Issue 17, Page 5107-5120, September 2026.Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma +1 more
wiley +1 more source
Conformational landscape and ligand-dependent clustering of the human type 2 IP<sub>3</sub> receptor. [PDF]
Nat CommunLiu C +4 more
europepmc +1 more source