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Inositol Hexaphosphate (IP6): A Novel Treatment for Pancreatic Cancer1
Journal of Surgical Research, 2005Ponnandai Somasundar +2 more
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IP6 (Inositol Hexaphosphate) as a Signaling Molecule
Current Signal Transduction Therapy, 2012Inositol hexaphosphate (IP6, InsP6) is a polyphosphorylated carbohydrate with diverse signaling properties. IP6 is plentiful in organisms as diverse as yeast, actinobacteria, mammals and plants. In the plant kingdom, IP6 accumulates during seed development; during germination it is broken down into lower inositol phosphates and micronutrients to ...
Abul Kalam Shamsuddin, Sanchita Bose
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Inositol Hexaphosphate (IP6) Inhibits Cellular Proliferation In Melanoma
Journal of Surgical Research, 2006Inositol Hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate found in food sources high in fiber content. We have previously reported IP6 to have significant inhibitory effects against pancreatic cancer in vitro. We hypothesized that the IP6 would significantly inhibit cell growth of cutaneous melanoma in vitro.The melanoma ...
Irfan, Rizvi +5 more
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IP6 in Cancer Therapy: Past, Present and Future
Current Cancer Therapy Reviews, 2010Inositol hexaphosphate (IP6) and its derivatives are naturally occurring, most abundant polyphosphorylated carbohydrates in organisms as diverse as yeast, endo-parasites, mammals and plants. IP6 represents a major metabolic pool in cellular phosphate pathways involved in vital functions such as signal transduction, regulation of cell proliferation and ...
Agata Matejuk, Abulkalam Shamsuddin
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IP6 Kinase Inhibitor Screening Assays
Inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (IP7), play crucial roles in various biological processes. Pharmacologic inhibition of IP6K has potential therapeutic benefits for treating type II diabetes, venous thrombosis, chronic kidney disease, and psychiatric disorders.Huijun, Wei, James C, Barrow
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Mammary tumor inhibition by IP6: a review.
Anticancer research, 2000While most studies of diet and breast cancer are focused on the role of fat, very few have addressed the effect of fiber. Emerging epidemiological data, and careful review of previous studies point to a negative correlation of breast cancer with high fiber cereal diets.
A M, Shamsuddin, I, Vucenik
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Antiplatelet activity of inositol hexaphosphate (IP6).
Anticancer research, 2000Platelet adhesion to endothelial cells, their aggregation and subsequent release of platelet-derived mediators are key steps in the pathogenesis of thrombosis and atherosclerosis. Using impedance technology the effect of inositol hexaphosphate (IP6) on platelet aggregation and adenosine triphosphate (ATP) release were simultaneously measured in whole ...
I, Vucenik +2 more
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Henley Gate, Ipswich, Suffolk, IP6 9AU
2016The site was on undulating land in an area of mostly heavy clay soils derived from the underlying Lowestoft Till. A localised deposit of glacial sand and gravel forms a distinct knoll at the east end of the site. A probable Later Bronze Age un-urned cremation was found on relatively high ground overlooking a valley to the north of the site.
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Metabolism and cellular functions of IP6: a review.
Anticancer research, 2000Inositol hexaphosphate (IP6) has a demonstrably effective anti-cancer action against a variety of experimental tumors. However, the mechanisms of its actions are yet to be completely discerned. Studies in my laboratory have shown that IP6 is rather rapidly absorbed by rats in vivo.
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Enrich and switch: IP6 and maturation of HIV-1 capsid
Nature Structural & Molecular Biology, 2023Chunxiang Wu, Yong Xiong
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