Results 11 to 20 of about 317 (79)

Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals

Molecules, 2020
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds.
Seulgi Lee, Min-Gyu Kim, Hyoungjoon Ahn   +2 more
exaly   +3 more sources

Inositol pyrophosphates as multifaceted metabolites in the regulation of mammalian signaling networks

Animal Cells and Systems, 2018
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases,
Seung Ju Park, Seulgi Lee, Seung Eun Park   +2 more
exaly   +2 more sources

Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions [PDF]

Journal of Medicinal Chemistry, 2022
Yubai Zhou, Sandip Mukherjee, Daowei Huang   +2 more
exaly   +2 more sources

The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis

Advances in Biological Regulation, 2022
Yann Desfougeres, Danye Qiu, Robert K Harmel   +2 more
exaly   +2 more sources

High extracellular phosphate increases platelet polyphosphate content

Platelets, 2021
Platelet-derived extracellular polyphosphate (PolyP) is a major mediator of thrombosis. PolyP is a linear chain of inorganic phosphate (Pi) and is stored in platelet dense granules.
Nima Abbasian, Matthew T. Harper
doaj   +1 more source

Inositol polyphosphates and target of rapamycin kinase signalling govern photosystem II protein phosphorylation and photosynthetic function under light stress in Chlamydomonas

New Phytologist, Volume 232, Issue 5, Page 2011-2025, December 2021., 2021
Summary Stress and nutrient availability influence cell proliferation through complex intracellular signalling networks. In a previous study it was found that pyro‐inositol polyphosphates (InsP7 and InsP8) produced by VIP1 kinase, and target of rapamycin (TOR) kinase signalling interacted synergistically to control cell growth and lipid metabolism in ...
Inmaculada Couso, Amanda L. Smythers, Megan M. Ford, James G. Umen, José L. Crespo, Leslie M. Hicks   +5 more
wiley   +1 more source

The PPIP5K Family Member Asp1 Controls Inorganic Polyphosphate Metabolism in S. pombe

Journal of Fungi, 2021
Inorganic polyphosphate (polyP) which is ubiquitously present in both prokaryotic and eukaryotic cells, consists of up to hundreds of orthophosphate residues linked by phosphoanhydride bonds.
Marina Pascual-Ortiz, Eva Walla, Ursula Fleig, Adolfo Saiardi   +3 more
doaj   +1 more source

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase

Molecules, 2021
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao, Ruth Manorama, Shubhra Ganguli, Mithun C. Madhusudhanan, Rashna Bhandari, Kana M. Sureshan   +5 more
doaj   +1 more source

Identity and functions of inorganic and inositol polyphosphates in plants

New Phytologist, Volume 225, Issue 2, Page 637-652, January 2020., 2020
Summary Inorganic polyphosphates (polyPs) and inositol pyrophosphates (PP‐InsPs) form important stores of inorganic phosphate and can act as energy metabolites and signaling molecules. Here we review our current understanding of polyP and inositol phosphate (InsP) metabolism and physiology in plants.
Laura Lorenzo‐Orts, Daniel Couto, Michael Hothorn   +2 more
wiley   +1 more source

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Molecular Metabolism, 2016
Objective: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration.
Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C. Barrow, Baoji Xu, Michael D. Cameron, Theodore M. Kamenecka, Anutosh Chakraborty   +10 more
doaj   +1 more source