Results 21 to 30 of about 317 (79)

Are Inositol Polyphosphates the Missing Link in Dynamic Cullin RING Ligase Regulation by the COP9 Signalosome?

Biomolecules, 2019
The E3 ligase activity of Cullin RING Ligases (CRLs) is controlled by cycles of neddylation/deneddylation and intimately regulated by the deneddylase COP9 Signalosome (CSN), one of the proteasome lid-CSN-initiation factor 3 (PCI) domain-containing “
Xiaozhe Zhang, Feng Rao
doaj   +1 more source

The enzymes of human diphosphoinositol polyphosphate metabolism

The FEBS Journal, Volume 281, Issue 1, Page 14-33, January 2014., 2014
This review covers the three classes of enzymes involved in the metabolism of diphosphoinositol polyphosphates – inositol hexakisphosphate kinases (IP6K), inositol hexakisphosphate and diphosphoinositol‐pentakisphosphate kinases (PPIP5K), and diphosphoinositol polyphosphate phosphohydrolases (DIPP).
Mark P. Thomas, Barry V. L. Potter
wiley   +1 more source

Acid Phosphatases of Budding Yeast as a Model of Choice for Transcription Regulation Research

Enzyme Research, Volume 2011, Issue 1, 2011., 2011
Acid phosphatases of budding yeast have been studied for more than forty years. This paper covers biochemical characteristics of acid phosphatases and different aspects in expression regulation of eukaryotic genes, which were researched using acid phosphatases model.
Elena V. Sambuk, Anastasia Yu. Fizikova, Vladimir A. Savinov, Marina V. Padkina, Hong-Jian Zhu   +4 more
wiley   +1 more source

Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain

Molecular Metabolism, 2017
Objective: IP6 kinases (IP6Ks) regulate cell metabolism and survival. Mice with global (IP6K1-KO) or adipocyte-specific (AdKO) deletion of IP6K1 are protected from diet induced obesity (DIO) at ambient (23 °C) temperature.
Qingzhang Zhu, Sarbani Ghoshal, Richa Tyagi, Anutosh Chakraborty   +3 more
doaj   +1 more source

Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis.

PLoS ONE, 2014
The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Francesca Pisani, Thomas Livermore, Giuseppina Rose, Jonathan Robert Chubb, Marco Gaspari, Adolfo Saiardi   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

Untersuchung der Adressierbarkeit des Cysteinoms der Proteinkinasen durch Kovalente Fragmente

Angewandte Chemie, Volume 137, Issue 8, February 17, 2025.
Trotz umfangreicher Forschungsarbeiten an kovalenten Kinaseinhibitoren bleibt ein Großteil des „Cysteinoms“ der Proteinkinasen unerforscht. Hier skizzieren wir einen verallgemeinerbaren Ansatz zur Adressierung von Cysteinen der ATP‐Bindetasche mit fragmentartigen kovalenten Inhibitoren.
Guiqun Wang, Nico J. Seidler, Sandra Röhm, Yufeng Pan, Xiaojun Julia Liang, Lisa Haarer, Benedict‐Tilman Berger, Saran Aswathaman Sivashanmugam, Valentin R. Wydra, Michael Forster, Stefan A. Laufer, Apirat Chaikuad, Matthias Gehringer, Stefan Knapp   +13 more
wiley   +1 more source

Probing the Protein Kinases′ Cysteinome by Covalent Fragments

Angewandte Chemie International Edition, Volume 64, Issue 8, February 17, 2025.
Despite extensive research on covalent kinase inhibitors, much of the protein kinases’ “cysteinome” remains unexplored. Here, we outline a generalizable approach to sample ATP‐site cysteines with fragment‐like covalent inhibitors. Thereby, we significantly expand the repertoire of targetable cysteines in the kinome, provide insights into unique binding
Guiqun Wang, Nico J. Seidler, Sandra Röhm, Yufeng Pan, Xiaojun Julia Liang, Lisa Haarer, Benedict‐Tilman Berger, Saran Aswathaman Sivashanmugam, Valentin R. Wydra, Michael Forster, Stefan A. Laufer, Apirat Chaikuad, Matthias Gehringer, Stefan Knapp   +13 more
wiley   +1 more source

Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors. [PDF]

ACS Med Chem Lett, 2023
Heitmann T, Liao G, de León P, Ernst G, Buchler I, Wei H, Shlevkov E, Brown D, Fitzek M, Collier M, Smith DM, Barrow JC.   +11 more
europepmc   +1 more source