Emetine Is Not Ipecac: Considerations for Its Use as Treatment for SARS-CoV2 [PDF]
Pharmaceuticals, 2020 Emetine is a potent antiviral that acts on many viruses in the low-nM range, with several studies in animals and humans demonstrating antiviral activity.
Martin D. Bleasel, Gregory M. Peterson
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Emetine, Ipecac, Ipecac Alkaloids and Analogues as Potential Antiviral Agents for Coronaviruses [PDF]
Pharmaceuticals, 2020 The COVID-19 coronavirus is currently spreading around the globe with limited treatment options available. This article presents the rationale for potentially using old drugs (emetine, other ipecac alkaloids or analogues) that have been used to treat ...
Martin D. Bleasel, Gregory M. Peterson
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Mechanisms of antiviral action and toxicities of ipecac alkaloids: Emetine and dehydroemetine exhibit anti-coronaviral activities at non-cardiotoxic concentrations [PDF]
Virus ResearchThe emergence of highly infectious pathogens with their potential for triggering global pandemics necessitate the development of effective treatment strategies, including broad-spectrum antiviral therapies to safeguard human health.
Viktoriya S. Sidorenko +24 more
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Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor [PDF]
Frontiers in Pharmacology, 2017 Cyclotides are plant derived, cystine-knot stabilized peptides characterized by their natural abundance, sequence variability and structural plasticity. They are abundantly expressed in Rubiaceae, Psychotrieae in particular.
Mohsen Fahradpour +8 more
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Gene expression profiling before and after internode culture for adventitious shoot formation in ipecac [PDF]
BMC Plant Biology, 2022 Background In ipecac (Carapichea ipecacuanha (Brot.) L. Andersson), adventitious shoots can be induced simply by placing internodal segments on phytohormone-free culture medium.
Karin Okazaki +6 more
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Reproductive studies on ipecac (Cephaelis ipecacuanha (Brot.) A. Rich; Rubiaceae): meiotic behavior and pollen viability [PDF]
Brazilian Journal of Biology, 2006 Reproductive studies were carried out on Brazilian accessions of ipecac, Cephaelis ipecacuanha. Meiotic behavior was studied using the squashing technique.
M. M. Souza +3 more
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Toxicology Reports, 2015 Trichothecene mycotoxins, potent translational inhibitors that are associated with human food poisonings and damp-building illnesses, are of considerable concern to animal and human health.
Wenda Wu +3 more
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Cephaeline promotes ferroptosis by targeting NRF2 to exert anti-lung cancer efficacy [PDF]
Pharmaceutical BiologyContext Cephaeline is a natural product isolated from ipecac (Cephaelis ipecacuanha [Brot.] A. Rich. [Rubiaceae]). It exhibits promising anti-lung cancer activity and ferroptosis induction may be a key mechanism for its anti-lung cancer effect.Objectives
Peng Chen +3 more
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Dual effects of ipecac alkaloids with potent antiviral activity against foot-and-mouth disease virus as replicase inhibitors and direct virucides [PDF]
International Journal of Veterinary Science and MedicineFoot-and-Mouth Disease (FMD) is a contagious, blistering disease caused by the Foot-and-Mouth Disease virus (FMDV), which affects livestock globally. Currently, no commercial antiviral agent is available for effective disease control.
Achiraya Pantanam +6 more
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Reproductive studies in ipecac (Psychotria ipecacuanha (Brot.) stockes; Rubiaceae): pollen development and morphology [PDF]
Brazilian Archives of Biology and Technology, 2008 The aim of this work was to carry out the reproductive studies on Brazilian accessions of ipecac, Psychotria ipecacuanha. It presented heterostyly, with brevistylous and longistylous flowers.
Margarete Magalhães Souza +3 more
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