Results 1 to 10 of about 2,090 (184)

M4-ipRGCs regulate contrast sensitivity in vision [PDF]

Cell Reports
Summary: Intrinsically photosensitive retinal ganglion cells (ipRGCs) in mice are comprised of at least 6 morphological subtypes, known as M1 to M6.
K.M. Daly, Xiaoyi Li, Shubham Rathore, Ruchi Komal, Corinne Beier, Grayson P. Ostermeyer, Joseph Leffler, Nazia M. Alam, Glen T. Prusky, Phyllis R. Robinson, Benjamin Sivyer, William N. Grimes, Jeffrey S. Diamond, R. Lane Brown, Samer Hattar   +14 more
doaj   +5 more sources

Selective Activation of ipRGC Modulates Working Memory Performance [PDF]

PLoS ONE
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are known to be sensitive to short-wavelength light (460-480 nm; blue or cyan light) and to play a role in regulating physiological responses such as circadian rhythms.
Yuta Suzuki, Hsin-I Liao, Shigeki Nakauchi   +2 more
exaly   +5 more sources

Tbr2-Dependent Parallel Pathways Regulate the Development of Distinct ipRGC Subtypes [PDF]

Communications Biology
The intrinsically photosensitive retinal ganglion cells (ipRGC) are the conduit between the retina and brain regions responsible for non-image-forming and image-forming vision.
Brad A Amendt, Ching-Kang Chen, Takae Kiyama   +2 more
exaly   +6 more sources

Intrinsically photosensitive retinal ganglion cells: Context-Dependent resilience and vulnerability [PDF]

Neurobiology of Sleep and Circadian Rhythms
Retinal ganglion cells (RGCs) exhibit marked heterogeneity in their susceptibility to injury and disease. Intrinsically photosensitive retinal ganglion cells (ipRGCs), a small subset of melanopsin-expressing RGCs involved in non-image-forming visual ...
Arianna Cella, Ludovic S. Mure
doaj   +2 more sources

Functional and morphological alterations of light detection circuits in postmortem retina from donors with different stages of Alzheimer’s-like pathology [PDF]

Communications Biology
Disruption of sleep and circadian rhythms is one of the earliest symptoms of Alzheimer’s disease (AD). Circadian entrainment and modulation of alertness are non-visual responses to light driven by intrinsically photosensitive retinal ganglion cells ...
Nicolae Sanda, Dan Milea, Eniko Kovari, Yixin Tong, Arianna Cella, Talayeh Brügger, Jens Hannibal, Kristof Levente Egervari, Johannes Alexander Lobrinus, Emmanuel Carrera, Gabriele Thumann, Sonja Kleinlogel, Antoine Adamantidis, Ludovic S. Mure   +13 more
doaj   +2 more sources

Melanopsin-mediated image statistics from natural and human-made environments [PDF]

Scientific Reports
Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) play a critical role in regulating physiological and behavioral responses to light.
Pablo A. Barrionuevo, Francisco Diaz-Barrancas   +1 more
doaj   +2 more sources

Bipolar cell networks underlying steady-state intensity encoding in intrinsically photosensitive retinal ganglion cells [PDF]

iScience
Summary: Intrinsically photosensitive retinal ganglion cells (ipRGCs) encode ambient light intensity at steady-state and drive physiology even in the absence of melanopsin, but the synaptic basis of such encoding remains unclear.
Shai Sabbah, Carin Papendorp, Inbar Behrendt, Hala Rasras, Jesse Cann, Megan L. Leyrer, Elizabeth Koplas, Marjo Beltoja, Cameron Etebari, Ali Noel Gunesch, Luis Carrete, Min Tae Kim, Gabrielle Manoff, Ananya Bhatia-Lin, Tiffany Zhao, Henry Dowling, Kevin L. Briggman, David M. Berson   +17 more
doaj   +2 more sources

Genetic tuning of retinal ganglion cell subtype identity to drive visual behavior [PDF]

Nature Communications
The distinct blend of molecular and cellular features that define neuronal subtype identity are central to shaping how individual subtypes impact animal behavior.
Marcos L. Aranda, Jacob D. Bhoi, Omar A. Payán Parra, Seul Ki Lee, Tomoko Yamada, Yue Yang, Tiffany M. Schmidt   +6 more
doaj   +2 more sources

Defining Spatial Nonuniformities of All ipRGC Types Using an Improved Opn4cre Recombinase Mouse Line

Cell Reports Methods
Summary: Intrinsically photosensitive retinal ganglion cells (ipRGCs) play a crucial role in several physiological light responses. In this study, we generate an improved Opn4cre knockin allele (Opn4cre(DSO)), which faithfully reproduces endogenous Opn4 ...
Shane D'Souza, Richard A Lang
exaly   +3 more sources

Blue light stimulation of the blind spot in human: from melanopsin to clinically relevant biomarkers of myopia [PDF]

Bioelectronic Medicine
The protective effects of time spent outdoors emphasize the major role of daylight in myopia. Based on the pathophysiology of myopia, the impact of blue light stimulation on the signaling cascade, from melanopsin at the blind spot to clinically relevant ...
Ana Amorim-de-Sousa, Ranjay Chakraborty, Michael J. Collins, Paulo Fernandes, José González‑Méijome, Jens Hannibal, Hosein Hoseini-Yazdi, Scott A. Read, Jens Ellrich, Tim Schilling   +9 more
doaj   +2 more sources