Results 161 to 170 of about 3,566 (193)

Chemogenetic Activation of ipRGCs Drives Changes in Dark-Adapted (Scotopic) Electroretinogram

open access: yesInvestigative Ophthalmology and Visual Science, 2016
The purpose of this study was to investigate the impact of activating melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) on dark-adapted (scotopic) electroretinograms (ERG).We used mice (Opn4Cre/+) expressing cre recombinase in melanopsin-expressing cells for a targeted gene delivery of a chemogenetic Gq-coupled receptor,
Nina Milosavljevic   +2 more
exaly   +5 more sources

Domain of Metamers Exciting Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) and Rods [PDF]

open access: yesJournal of the Optical Society of America A: Optics and Image Science, and Vision, 2012
Any stimulus can be described as composed of two components-a fundamental color stimulus that controls the three cone responses and a metameric black that has no effect on cones but can drive photoreceptors other than cones [e.g., rods and melanopsin expressing retinal ganglion cells (ipRGCs)]. The Cohen and Kappauf [Am. J. Psychol.
Françoise Viénot
exaly   +5 more sources

The Role of ipRGCs in Ocular Growth and Myopia Development

open access: yesScience Advances, 2022
The increasing global prevalence of myopia calls for elaboration of the pathogenesis of this disease. Here, we show that selective ablation and activation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in developing mice induced myopic and hyperopic refractive shifts by modulating the corneal radius of curvature (CRC) and axial length (
Shi-Jun Weng, Xu Han, Yong-Mei Zhong
exaly   +3 more sources

Photoentrainment and Pupillary Light Reflex Are Mediated by Distinct Populations of ipRGCs [PDF]

open access: yesNature, 2011
Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin and regulate a wide array of light-dependent physiological processes. Genetic ablation of ipRGCs eliminates circadian photoentrainment and severely disrupts the pupillary light reflex (PLR).
Samer Hattar   +2 more
exaly   +3 more sources

Circadian rhythm, ipRGCs, and dopamine signalling in myopia

Graefe's Archive for Clinical and Experimental Ophthalmology, 2023
Myopia, a common ophthalmic disorder, places a high economic burden on individuals and society. Genetic and environmental factors influence myopia progression; however, the underlying mechanisms remain unelucidated. This paper reviews recent advances in circadian rhythm, intrinsically photosensitive retinal ganglion cells (ipRGCs), and dopamine (DA ...
Licheng Li   +5 more
openaire   +2 more sources

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