Results 81 to 90 of about 480,657 (273)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Warta LPM, 2015 The purpose of this community service, assess and understand; 1) learning implementation strategy IPS (Social Sciences) Curriculum 2013 based on lesson study in the School of Muhammadiyah Kartasura.
Tjipto Subadi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Representable linear functionals on partial *-algebras
, 2011 A GNS - like *-representation of a \pa\ $\A$ defined by certain representable linear functionals on $\A$ is constructed. The study of the interplay with the GNS construction associated with invariant positive sesquilinear forms (ips) leads to the notions
Bagarello, Fabio +2 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Jurnal Inovasi dan Teknologi Pembelajaran, 2019 Abstrak: Tujuan dari penelitian ini untuk menghasilkan multimedia interaktif yang dapat digunakan untuk pembelajaran mandiri yang telah melalui serangkaian validasi sehingga dapat digunakan dalam mata pelajaran IPS kelas VIII. Jenis penelitian ini adalah
Ardian Ramadhan Wijaya +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
IPS Observation System for Miyun 50m Radio Telescope and Its Acceptance Observation
, 2012 Ground-based observation of Interplanetary Scintillation(IPS) is an important approach of monitoring solar wind. A ground-based IPS observation system is newly implemented on 50m radio telescope, Miyun station, National Astronomical Observatories ...
De-Qing Kong +13 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Revista Colombiana de Medicina Física y Rehabilitación, 2016 Introducción La enfermedad cardiovascular (ECV) constituye la primera causa de muerte en todo el mundo. Objetivos: Identificar el riesgo cardiovascular y riesgo para hipertensión arterial en pacientes de atención primeria en salud.
Javier Eliecer Pereira Rodriguez +3 more
doaj +1 more source