Results 101 to 110 of about 102,759 (307)
Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. [PDF]
, 2016 In this study, because excessive polycythemia is a predominant trait in some high-altitude dwellers (chronic mountain sickness [CMS] or Monge's disease) but not others living at the same altitude in the Andes, we took advantage of this human experiment ...
Appenzeller, Otto +9 more
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, 2023 Differentiation is the process where an unspecialized cell acquires cellular traits that allow it to perform specialized functions. Indeed, the actual potential of iPSCs rest in their direct differentiation to various types of somatic cells. In order to use iPSCs to treat disease or as research tools to study diseases, fully functioning specialized ...
openaire +2 more sources
iPSC for modeling neurodegenerative disorders
Regenerative Therapy, 2020 Neurodegenerative disorders such as Parkinson's and Alzheimer's disease, are fundamental health concerns all around the world. The development of novel treatments and new techniques to address these disorders, are being actively studied by researchers and medical personnel.
Valeria Valadez-Barba +6 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Patient‐derived cardiac organoids reveal key features of Duchenne muscular dystrophy cardiomyopathy, including apoptosis, oxidative stress, calcium handling defects, and mechanical remodeling. By integrating organoids into alginate–gelatin bioprinted constructs, disease phenotypes are organized into scalable 3D cardiac tissues displaying extracellular ...
Vittoria Marini +15 more
wiley +1 more source
Scientific ReportsOsteoporosis is a metabolic bone disease that impairs bone mineral density, microarchitecture, and strength. It requires continuous management, and further research into new treatment options is necessary.
Ye Ji Eom +5 more
doaj +1 more source
Experimental and Molecular Medicine, 2019 Regenerative medicine: Engineering compatible stem cells Blocking the expression of genes that regulate the immune response in therapeutic stem cells could increase the chances of success following transplantation.
Yeonsue Jang +6 more
doaj +1 more source
Molecular gas associated with the IRAS-Vela shell [PDF]
, 1998 We present a survey of molecular gas in the J = 1 -> 0 transition of 12CO towards the IRAS Vela shell. The shell, previously identified from IRAS maps, is a ring-like structure seen in the region of the Gum Nebula.
Rajagopal, Jayadev, Srinivasan, G.
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Reducing genomic instability in iPSCs
Oncotarget, 2015 Over the past 15 years, pluripotent cells, either embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs), became a formidable cellular platform to study developmental biology, model disease in vitro and pursue new drug discoveries. Furthermore, the promise of using endless cell derivatives from pluripotent cells to treat incurable ...
Ruiz S, Fernandez-Capetillo O
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Advanced Healthcare Materials, EarlyView.This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady +5 more
wiley +1 more source
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. [PDF]
, 2019 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear transactive response DNA-binding protein 43 (TDP-43).
Artates, Jon W +19 more
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