Results 171 to 180 of about 104,261 (287)

All‐Optical Control of Bidirectional Polarization Switching in Ferroelectric Heterostructures for Neuromorphic and In‐Memory Computing

Advanced Science, EarlyView.
We propose an optical ferroelectric field‐effect transistor, composed of a MoS2/CIPS heterostructure, demonstrates the feasibility of all‐optical nonvolatile memory, neuromorphic computing, and logic‐in‐memory operations. The device exhibits reversible light‐controlled memory states, retina‐like synaptic plasticity, and wavelength‐selective ...
Jingjie Niu, Jiahui Lyu, Jie Li, Koyal Suman Samantaray, Cheolhwa Jang, Yoonmyung Lee, Ji‐Sang Park, Sungjoo Lee   +7 more
wiley   +1 more source

Identifying GFAP-expressing cell susceptibility to SARS-CoV-2 infection using human iPSC-derived neural cells. [PDF]

Sci Rep
Asavapanumas N, Chaiwijit P, Suksatu A, Kasemsinsup S, Saikachain N, Chantaraamporn J, Chieowisaman S, Nguantad S, Jevapatarakul D, Thungsatianpun N, Pornsukjantra T, Chokpanuwat T, Manopwisedjaroen S, Bhukhai K, Wongtrakoongate P, Hongeng S, Matangkasombut P, Charoensawan V, Thitithanyanont A.   +18 more
europepmc   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

The role of autophagy in microwave radiation induced toxicity in iPSC-derived cardiomyocytes. [PDF]

Curr Res Toxicol
Zhang C, Liu Z, Wang Y, Deng W, Wang H, Zhang J, Feng Q.   +6 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Cerebellar organoids model cell type-specific FOXP2 expression during human cerebellar development

Disease Models & Mechanisms
Elizabeth J. Apsley, Joey Riepsaame, Yin Chun Cheng, Sally A. Cowley, Esther B. E. Becker   +4 more
doaj   +1 more source

Non-physiological potassium concentrations in commercial culture media trigger acute seizure-like activity in human iPSC-derived neurons. [PDF]

Sci Rep
Lyckenvik T, Izsak J, Arthursson E, Forsberg M, Johansson K, Zetterberg H, Axelsson M, Wasling P, Hanse E, Theiss S, Illes S.   +10 more
europepmc   +1 more source

Infrared Machine Vision System Based on Te NWs‐Au NPs Plasmonic Optoelectronic Memristor for Motion Detection

Advanced Science, EarlyView.
A plasmonic optoelectronic memristor based on Te nanowires‐Au nanoparticles/ι‐carrageenan enables IR‐programmed and visiblelight‐erased non‐volatile conductance. The all‐photonic write/erase scheme supports in‐sensor logic and real‐time motion detection in darkness.
Jingyao Bian, Yongxing Zhu, Ye Tao, Zhongqiang Wang, Xiaoning Zhao, Ya Lin, Haiyang Xu, Yichun Liu   +7 more
wiley   +1 more source

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

Advanced Science, EarlyView.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka, Yuhei Higashi, Suguru Saito, Solmaz Pourgonabadi, Honami Honjoh, Sho Ishigaki, Peter C. Harris, Lisa M. Satlin, Michifumi Yamashita, Ryuji Morizane   +9 more
wiley   +1 more source

CRISPR and Beyond: Genome-Editing Strategies in Retinal Stem Cell Research. [PDF]

Cells
Woronkowicz M, Thomas MN, Saram SJ, Carr AF, Alonso-Carriazo Fernandez A, Butt Z, Skopiński P, Ramsden CM.   +7 more
europepmc   +1 more source