Results 171 to 180 of about 102,759 (307)

Endothelial Cell‐Based Vascular Bandages for Blood–Brain Barrier Repair and Targeted siRNA Delivery

Advanced Science, EarlyView.
mECs restore blood–brain barrier function after cerebral ischemia–reperfusion by simultaneously targeting, supporting, and regulating the damaged vasculature. mECs home to injured cerebral vessels through interactions with highly expressed VLA‐4, reinforce endothelial integrity by forming new junctions, and, upon OGD‐SN treatment, acquire enhanced ...
Yaosheng Li, Yunfei Dong, Yaode He, Juanjuan Zheng, Hui Liu, Lu Li, Xiaoxu Hao, Yanli Zhao, Zefeng Yang, Yuankai Sun, Zhiwei Du, Bo Zhao, Weihang Zhou, Honghui Wu, Tianyuan Zhang, Jiahe Wu, Xiangrui Liu, Xianzhen Yin, Zhicai Chen, Rui Xue, Min Lou, Zhen Gu, Xinchi Jiang, Jianqing Gao   +23 more
wiley   +1 more source

iPSC-Derived Endothelial Cells as Experimental Models for Predictive and Personalized Strategies in Cardiovascular and Cerebrovascular Disease. [PDF]

Int J Mol Sci
Fontanelli L, Castronovo A, Ferri C, Vozzi F, Recchia FA, Borghini A.   +5 more
europepmc   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Adaptive-like CAR-iPSC-CD4⁺ T cells outperform CD8⁺ counterparts in sustained ALL control. [PDF]

Inflamm Regen
Guo Q, Zhang C, Wang B, Iriguchi S, Ishikawa A, Minagawa A, Ishii T, Kawai Y, Kaneko S.   +8 more
europepmc   +1 more source

Microgel‐Based Hierarchical Porous Hydrogel Patch with Adhesion and Resilience for Myocardial Infarction

Advanced Science, EarlyView.
This study develops a hierarchically porous hydrogel patch strategy (HPMP), based on gas‐shearing microfluidics and an aqueous two‐phase system to fabricate porous microgels as microgel‐based bioinks. The porous microgels with controllable porous structure exhibit excellent cellular behavior.
Ziyang Liu, Leyan Xuan, Yingying Hou, Ting Xie, Jieting Li, Junjie Cai, Siyu Zhang, Yingling Miao, Ning Hou, Gen He, Maobin Xie, Xiyong Yu, Mingen Xu, Guosheng Tang   +13 more
wiley   +1 more source

A pathogenic titin missense mutation in hiPSC-derived cardiomyocytes predisposes to ventricular fibrillation in acute ST-segment elevation myocardial infarction. [PDF]

Front Cardiovasc Med
Ji YY, Wu Y, Sun J, Lin XX, Chen XM, Ji CC, Liu LJ, Cheng YJ, Wu SH.   +8 more
europepmc   +1 more source

Imidazole Post‐Treated Self‐Assembled Monolayers for Inverted Perovskite Solar Cells

Advanced Science, EarlyView.
A post‐treatment strategy using imidazole derivatives (4,5‐DI and 4,5‐D‐2‐MI) enhances the Me‐4PACz/perovskite interface by improving wettability, promoting perovskite films, and optimizing energy level alignment, resulting in higher efficiency and improved stability in inverted perovskite solar cells.
Ihtesham Ghani, Shi Tingshu, Shehzad Ahmed, Zhuo Hongbin, Zhu Zirun, Yu Zhang, Peng You, Imran Muhammad, Tang Zeguo, Danish Khan   +9 more
wiley   +1 more source

Cerebellar organoids model cell type-specific FOXP2 expression during human cerebellar development

Disease Models & Mechanisms
Elizabeth J. Apsley, Joey Riepsaame, Yin Chun Cheng, Sally A. Cowley, Esther B. E. Becker   +4 more
doaj   +1 more source

Aberrant CDK4/6-driven cell-cycle reentry drives neuronal loss and defines a therapeutic target in C9orf72 ALS/FTD. [PDF]

iScience
Lian L, Robinson H, Daniels N, Prieto GA, Poplawski GHD, Lopez-Gonzalez R.   +5 more
europepmc   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source