Results 211 to 220 of about 104,261 (287)

Disease modelling using human iPSCs [PDF]

Human Molecular Genetics, 2016
openaire   +2 more sources

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Generation and characterization of human induced pluripotent stem cells from neuropathologically confirmed multiple system atrophy patient-derived fibroblasts. [PDF]

Front Immunol
Alemany-Ribes M, Pérez-Soriano A, Santos A, Severino J, Dangla-Valls A, Gigirey-Suárez M, Cohen D, Ezquerra M, Fernandez-Santiago R, Fernandez M, Martí MJ, Baekelandt V, Peelaerts W, Melki R, Compta Y, Batlle-Morera L.   +15 more
europepmc   +1 more source

Bioinspired Crossmodal Tactile Sensory Nerve for High‐Accurate Object Recognition

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
An artificial crossmodal sensory neuron system (ACSNS) that combines a complementary memristor with high‐sensitivity pressure–temperature bimodal sensors, which integrate tactile perception, information storage, and neuromorphic computing. With the aid of machine learning, this ACSNS presents an improved accuracy of 96.67% in recognizing temperatures ...
Delu Chen, Yuetong Han, Xiaodong Wang, Wanli Cheng, Jianjie He, Xing Li, Yoshifumi Oshima, Chongxin Shan, Shaobo Cheng   +8 more
wiley   +1 more source

CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease. [PDF]

Alzheimers Res Ther
Lu W, Kawatani K, Ren Y, Nambara T, Jia L, Jeevaratnam S, Lee E, Martinez PR, Izhar T, Wang N, Raulin AC, Wszolek ZK, Bu G, Kanekiyo T, Li Y.   +14 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Engineering Mitochondrial Biogenesis in iPSC-CMs: CRISPR-Guided Approaches for Advanced Cardiomyocyte Development. [PDF]

J Cardiovasc Dev Dis
Shahannaz DC, Sugiura T, Ferrell BE, Yoshida T.   +3 more
europepmc   +1 more source

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, EarlyView.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source