Results 61 to 70 of about 5,242 (246)

Complex, low‐intensity, individualised naturalistic developmental behavioural intervention in toddlers and pre‐schoolers with autism spectrum disorder: The multicentre, observer‐blind, parallel‐group randomised‐controlled A‐FFIP trial

Journal of Child Psychology and Psychiatry, Volume 66, Issue 10, Page 1500-1513, October 2025.
Background Naturalistic developmental behavioural interventions (NDBI) may improve social communication in toddlers/pre‐school aged children with autism spectrum disorder (ASD). Here, we study efficacy of the low‐intensity, complex NDBI ‘Frankfurt Early Intervention Program for ASD’ (A‐FFIP) over 1 year by a confirmatory phase‐III, prospective ...
Christine M. Freitag, Marietta Kirchner, Lukas D. Sauer, Solvejg K. Kleber, Leonie Polzer, Naisan Raji, Christian Lemler, Ulrike Fröhlich, Tomasz Jarczok, Julia Geissler, Franziska Radtke, Melanie Ring, Veit Roessner, Regina Taurines, Michelle Noterdaeme, Karoline Teufel, Ziyon Kim, Janina Kitzerow‐Cleven   +17 more
wiley   +1 more source

Budget impact of the Oncotype DX® test compared to other gene expression tests in patients with early breast cancer in Germany

Cancer Treatment and Research Communications, 2022
Purpose: Gene expression tests can inform decisions on whether to recommend chemotherapy for patients with HR+, HER2- early breast cancer. The goal of this analysis was to compare treatment costs by an expanded budget impact model of reimbursed gene ...
M.P. Lux, C. Minartz, H. Müller-Huesmann, M.F. Sandor, K.H. Herrmann, S. Radeck-Knorre, A.S. Neubauer   +6 more
doaj   +1 more source

Systemic therapy in children and adolescents with mental disorders: a systematic review and meta-analysis

BMC Psychiatry
Background Systemic therapy (ST) is a psychotherapeutic intervention in complex human systems (both psychological and interpersonal). Cognitive behavioural therapy (CBT) is an established treatment for children and adolescents with mental disorders.
David Henry Seidel, Martina Markes, Ulrich Grouven, Claudia-Martina Messow, Wiebke Sieben, Marco Knelangen, Rieke Oelkers-Ax, Sebastian Grümer, Heike Kölsch, Mandy Kromp, Markus von Pluto Prondzinski   +10 more
doaj   +1 more source

Disagreement in primary study selection between systematic reviews on negative pressure wound therapy

BMC Medical Research Methodology, 2008
Background Primary study selection between systematic reviews is inconsistent, and reviews on the same topic may reach different conclusions. Our main objective was to compare systematic reviews on negative pressure wound therapy (NPWT) regarding their ...
Sauerland Stefan, McGauran Natalie, Peinemann Frank, Lange Stefan   +3 more
doaj   +1 more source

Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase‐IIa Randomized, Double‐Blind, Sham‐Controlled Feasibility Study

Autism Research, Volume 18, Issue 9, Page 1861-1876, September 2025.
ABSTRACT Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham‐controlled, double‐blind parallel‐group Phase‐
Christina Luckhardt, Magdalena Schütz, Andreas M. Mühlherr, Sara Boxhoorn, Christine Ecker, Hanna Mössinger, Julia Siemann, Fabienne Schlechter, Miguel Castelo‐Branco, Helena C. Pereira, Marianne Latinus, Camille Ricou, Frederique Bonnet‐Brilhault, Ricardo Salvador, Giulio Ruffini, Rafal Nowak, Michael Siniatchkin, Astrid Dempfle, Christine M. Freitag   +18 more
wiley   +1 more source

Requirements for benefit assessment in Germany and England – overview and comparison [PDF]

, 2014
Photograph of coin found by Stivvie Thomas by metal-detecting in fields south of Willy ...
Victor Ivandic
core   +1 more source

Prognostic Factors and Effect Modifiers in Patients With Relapse or Refractory Diffuse Large B‐Cell Lymphoma After Two Lines of Therapy: A Systematic Literature and Expert Clinical Review

European Journal of Haematology, Volume 115, Issue 2, Page 104-116, August 2025.
ABSTRACT Objectives The objective of this systematic literature review (SLR) combined with expert clinical review was to identify and rank prognostic factors and effect measure modifiers (EMMs) systematically and comprehensively in patients with relapsed or refractory (R/R) diffuse large B‐cell lymphoma (DLBCL) who initiate treatment after ≥ 2 prior ...
Bastian von Tresckow, Pau Abrisqueta, Irene Zamanillo, Ángel Serna, Yuting Kuang, Jennifer Uyei, Mohsin Shah, Laura Walsh, Eileen Thorley, Krystal Cantos, Emaan Rashidi, Christian Hampp, Jessica J. Jalbert, Alexi N. Archambault, Yingxin Xu, Shivani Aggarwal, Srikanth Ambati, Hesham Mohamed, Qiufei Ma, Ana Jiménez‐Ubieto   +19 more
wiley   +1 more source

Surrogatvalidierung durch Korrelation und Surrogate Threshold Effect – Ergebnisse von Simulationsstudien

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2017
Background: Progression-free survival (PFS) is often used instead of the patient-relevant endpoint overall survival (OS) in cancer clinical trials.
Gillhaus, Johanna, Goertz, Ralf, Jeratsch, Ulli, Leverkus, Friedhelm   +3 more
doaj   +1 more source

Patient relevant endpoints in oncology: Current issues in the context of early benefit assessment in Germany [PDF]

, 2014
The German AMNOG healthcare reform includes a mandatory early-benefit-assessment (EBA) at launch. As per German social code, EBA is based on registration trials and includes evaluation of the patient-relevant effect of the new medicines compared to an ...
Dabisch, Inna, Dethling, Jürgen, Dintsios, Charalabos-Markos, Drechsler, Melanie, Kalanovic, Daniel, Kaskel, Peter, Langer, Frank, Ruof, Jörg, Ruppert, Thorsten, Wirth, Daniel   +9 more
core   +1 more source

Further Practical Guidance on Adjusting Time‐To‐Event Outcomes for Treatment Switching

Pharmaceutical Statistics, Volume 24, Issue 4, July/August 2025.
ABSTRACT The objective of this article is to bring together the key current information on practical considerations when conducting statistical analyses adjusting long‐term outcomes for treatment switching, combining it with learnings from our own experience, thus providing a useful reference tool for analysts.
Claire Watkins, Eva Kleine, Miguel Miranda, Emmanuel Bourmaud, Orlando Doehring   +4 more
wiley   +1 more source