Results 61 to 70 of about 4,432 (206)

Complex, low‐intensity, individualised naturalistic developmental behavioural intervention in toddlers and pre‐schoolers with autism spectrum disorder: The multicentre, observer‐blind, parallel‐group randomised‐controlled A‐FFIP trial

Journal of Child Psychology and Psychiatry, Volume 66, Issue 10, Page 1500-1513, October 2025.
Background Naturalistic developmental behavioural interventions (NDBI) may improve social communication in toddlers/pre‐school aged children with autism spectrum disorder (ASD). Here, we study efficacy of the low‐intensity, complex NDBI ‘Frankfurt Early Intervention Program for ASD’ (A‐FFIP) over 1 year by a confirmatory phase‐III, prospective ...
Christine M. Freitag, Marietta Kirchner, Lukas D. Sauer, Solvejg K. Kleber, Leonie Polzer, Naisan Raji, Christian Lemler, Ulrike Fröhlich, Tomasz Jarczok, Julia Geissler, Franziska Radtke, Melanie Ring, Veit Roessner, Regina Taurines, Michelle Noterdaeme, Karoline Teufel, Ziyon Kim, Janina Kitzerow‐Cleven   +17 more
wiley   +1 more source

The Politics of Evidence Use in Health Policy Making in Germany-the Case of Regulating Hospital Minimum Volumes. [PDF]

, 2017
This article examines the role of scientific evidence in informing health policy decisions in Germany, using minimum volumes policy as a case study. It argues that scientific evidence was used strategically at various stages of the policy process both by
Ettelt, S
core   +3 more sources

Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase‐IIa Randomized, Double‐Blind, Sham‐Controlled Feasibility Study

Autism Research, Volume 18, Issue 9, Page 1861-1876, September 2025.
ABSTRACT Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham‐controlled, double‐blind parallel‐group Phase‐
Christina Luckhardt, Magdalena Schütz, Andreas M. Mühlherr, Sara Boxhoorn, Christine Ecker, Hanna Mössinger, Julia Siemann, Fabienne Schlechter, Miguel Castelo‐Branco, Helena C. Pereira, Marianne Latinus, Camille Ricou, Frederique Bonnet‐Brilhault, Ricardo Salvador, Giulio Ruffini, Rafal Nowak, Michael Siniatchkin, Astrid Dempfle, Christine M. Freitag   +18 more
wiley   +1 more source

Requirements for benefit assessment in Germany and England – overview and comparison [PDF]

, 2014
Photograph of coin found by Stivvie Thomas by metal-detecting in fields south of Willy ...
Victor Ivandic
core   +1 more source

Prognostic Factors and Effect Modifiers in Patients With Relapse or Refractory Diffuse Large B‐Cell Lymphoma After Two Lines of Therapy: A Systematic Literature and Expert Clinical Review

European Journal of Haematology, Volume 115, Issue 2, Page 104-116, August 2025.
ABSTRACT Objectives The objective of this systematic literature review (SLR) combined with expert clinical review was to identify and rank prognostic factors and effect measure modifiers (EMMs) systematically and comprehensively in patients with relapsed or refractory (R/R) diffuse large B‐cell lymphoma (DLBCL) who initiate treatment after ≥ 2 prior ...
Bastian von Tresckow, Pau Abrisqueta, Irene Zamanillo, Ángel Serna, Yuting Kuang, Jennifer Uyei, Mohsin Shah, Laura Walsh, Eileen Thorley, Krystal Cantos, Emaan Rashidi, Christian Hampp, Jessica J. Jalbert, Alexi N. Archambault, Yingxin Xu, Shivani Aggarwal, Srikanth Ambati, Hesham Mohamed, Qiufei Ma, Ana Jiménez‐Ubieto   +19 more
wiley   +1 more source

Surrogatvalidierung durch Korrelation und Surrogate Threshold Effect – Ergebnisse von Simulationsstudien

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2017
Background: Progression-free survival (PFS) is often used instead of the patient-relevant endpoint overall survival (OS) in cancer clinical trials.
Gillhaus, Johanna, Goertz, Ralf, Jeratsch, Ulli, Leverkus, Friedhelm   +3 more
doaj   +1 more source

Opportunities to improve the adoption of health-related quality of life evidence as part of the French Health Technology Assessment process

Health Research Policy and Systems, 2023
Objectives Patient’s health-related quality of life (HRQoL) is an important outcome measure that is considered by many payers and health technology assessment (HTA) bodies in the evaluation of treatments.
Hugo Larose, Myrto Lee, Jens Grueger, Amélie Anota, Nicolas Naïditch, Bruno Falissard, Mario Di Palma, Olivier Chassany, Laura Khalfallah-Neelz, Sarah Palazuelos-Muñoz, Aymeric Tetafort   +10 more
doaj   +1 more source

Further Practical Guidance on Adjusting Time‐To‐Event Outcomes for Treatment Switching

Pharmaceutical Statistics, Volume 24, Issue 4, July/August 2025.
ABSTRACT The objective of this article is to bring together the key current information on practical considerations when conducting statistical analyses adjusting long‐term outcomes for treatment switching, combining it with learnings from our own experience, thus providing a useful reference tool for analysts.
Claire Watkins, Eva Kleine, Miguel Miranda, Emmanuel Bourmaud, Orlando Doehring   +4 more
wiley   +1 more source

„Stärkerer Fokus auf die Methoden der Studiendurchführung“

Monitor Versorgungsforschung
Nach Prof. Dr. med. Peter Sawicki (2004 bis 2009) und Prof. Dr. med. Jürgen Windeler (2010 bis März 2023) ist seit April 2023 Dr. med. Thomas Kaiser der dritte Leiter des Instituts für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG).
Dr. med. Thomas Kaiser, Peter Stegmaier
doaj   +1 more source

Rationalisierung und Wettbewerb im Arzneimittelmarkt [PDF]

, 2012
Rationalisierungsmaßnahmen sind bei steigenden Ausgaben in einem vor allem durch Umlagen finanzierten Gesundheitssystem wichtige Mittel zur Erreichung einer effizienten Produktion und Allokation der Ressourcen.
Herr, Annika
core