Enhancing Drug Development for Paediatric Pulmonary Hypertension—An Integrative Perspective
Pulmonary Circulation, Volume 15, Issue 3, July 2025.ABSTRACT As with adult pulmonary hypertension (PH), high morbidity and mortality persist with diverse types of paediatric PH. Despite major advances in pharmacologic therapies based on extensive studies in adult PH, few drugs have been comprehensively studied in neonates, infants, and children, leaving current paediatric PH care largely dependent on ...
Steven H. Abman +14 more
wiley +1 more source
A proportional rule for setting reimbursement prices of new drugs and its mathematical consistency
BMC Health Services Research, 2020 Background Value-based pricing (VBP) of new drugs has been suggested both as a way to control health expenditures and to maximize health benefits based on the available resources. The purpose of this work is to present a simple mathematical proof showing
Afschin Gandjour
doaj +1 more source
Hazards Constitute Key Quantities for Analyzing, Interpreting and Understanding Time‐to‐Event Data
Biometrical Journal, Volume 67, Issue 3, June 2025.ABSTRACT Censoring makes time‐to‐event data special and requires customized statistical techniques. Survival and event history analysis therefore builds on hazards as the identifiable quantities in the presence of rather general censoring schemes. The reason is that hazards are conditional quantities, given previous survival, which enables estimation ...
Jan Beyersmann +2 more
wiley +1 more source
Bewertung des Informationspaketes „Wechseljahre“ des IQWiG
, 2009 Evidenz und Entscheidung: System unter Druck; 10.
Berger, B +3 more
openaire +1 more source
Patient relevant endpoints in oncology: Current issues in the context of early benefit assessment in Germany [PDF]
, 2014 The German AMNOG healthcare reform includes a mandatory early-benefit-assessment (EBA) at launch. As per German social code, EBA is based on registration trials and includes evaluation of the patient-relevant effect of the new medicines compared to an ...
Dabisch, Inna +9 more
core +1 more source
International Journal of Paediatric Dentistry, Volume 35, Issue 6, Page 1023-1025, November 2025.
Rokaia Ahmed Elagami +7 more
wiley +1 more source
Antero‐Lateral Subthalamic Nucleus Theta Stimulation Improves Verbal Fluency in Parkinson's Disease
Movement Disorders, Volume 40, Issue 6, Page 1195-1199, June 2025.Abstract Objective Low‐frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been associated with positive effects on verbal fluency (VF) in patients with Parkinson's disease. This prospective study investigates stimulation direction‐dependent and site‐specific effects of theta frequency DBS on VF. Methods In a double‐blind, cross‐
Hannah Schoenwald +12 more
wiley +1 more source
Subthalamic Deep Brain Stimulation: Mapping Non‐Motor Outcomes to Structural Connections
Human Brain Mapping, Volume 46, Issue 5, 01 April 2025.Delivering stimulation to the correct target is a challenge for deep brain stimulation. We propose a new approach that allows condensing a large battery of scores onto a few main dimensions, identifying the structural connections associated with each dimension, and estimating changes in individual scores based on their stimulation.
Garance M. Meyer +12 more
wiley +1 more source
Monitor VersorgungsforschungDer Gesetzgeber hat mit dem 2019 eingeführten Instrument der anwendungsbegleitenden Datenerhebung (AbD) die Möglichkeit geschaffen, vergleichende Daten in der laufenden Versorgung zu erheben.
Dr. rer. nat. Matthias Wilken +1 more
doaj +1 more source
Systematic review on inhaled corticosteroid monotherapy and its efficacy and safety in longterm treatment of patients with chronic obstructive pulmonary disease (COPD) [PDF]
--chronic obstructive pulmonary disease,COPD,corticosteroids,systematic review,chronisch obstruktive Lungenerkrankung,COPD,Kortikosteroid,systematischer ...
Buchberger, Barbara +4 more
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