Results 11 to 20 of about 14,109 (250)

Biomimetic cell membrane decorated ZIF‐8 nanocarriers with IR‐780 and doxorubicin loading for multiple myeloma treatment

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Several therapeutic drugs including heptamethine cyanine dye (IR‐780), doxorubicin (DOX), and others have exhibited positive outcomes in the treatment of multiple myeloma (MM).
Guangtao Gao, Junyi Che, Peipei Xu, Bing Chen, Yuanjin Zhao   +4 more
doaj   +2 more sources

Hyperbaric oxygen enhanced the chemotherapy of mitochondrial targeting molecule IR-780 in bladder cancer. [PDF]

J Cancer Res Clin Oncol, 2023
Bladder cancer has a high rate of recurrence and drug resistance due to the lack of effective therapies. IR-780 iodide, a near-infrared (NIR) mitochondria-targeting fluorescent agent, has been demonstrated to achieve higher selectivity than other drugs in different tumor types and exhibited tumor-killing effects in some cancers.
Shen C, Yue X, Dai L, Wang J, Li J, Fang Q, Zhi Y, Shi C, Li W.   +8 more
europepmc   +3 more sources

IR-780 dye for near-infrared fluorescence imaging in prostate cancer. [PDF]

Med Sci Monit, 2015
The aim of this study was to investigate near-infrared fluorescence (NIRF) imaging as a novel imaging modality that allows for early detection of cancer and real-time monitoring to acquire related information. IR-780 iodide, a lipophilic dye, accumulates selectively in breast cancer cells and drug-resistant human lung cancer cells, with a peak emission
Yi X, Yan F, Wang F, Qin W, Wu G, Yang X, Shao C, Chung LW, Yuan J.   +8 more
europepmc   +4 more sources

IR-780 Dye as a Sonosensitizer for Sonodynamic Therapy of Breast Tumor. [PDF]

Sci Rep, 2016
AbstractSonodynamic therapy (SDT) has become a new modality for cancer therapy through activating certain chemical sensitizers by ultrasound (US). Discovery and development of novel sonosensitizers are attracting extensive attentions. Here, we introduce IR-780 iodide, a lipophilic heptamethine dye with a peak optical absorption of 780 nm wavelength ...
Li Y, Zhou Q, Deng Z, Pan M, Liu X, Wu J, Yan F, Zheng H.   +7 more
europepmc   +4 more sources

IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice. [PDF]

Acta Pharmacol Sin, 2018
Cancer metastasis is responsible for over 90% of breast cancer-related deaths, and inhibiting lymph node metastasis is an option to treat metastatic disease. Herein, we report the use of IR-780-loaded polymeric micelles (IPMs) for effective photothermal therapy (PTT) of breast cancer lymphatic metastasis.
He B, Hu HY, Tan T, Wang H, Sun KX, Li YP, Zhang ZW.   +6 more
europepmc   +4 more sources

Dye-loaded mesoporous polydopamine nanoparticles for multimodal tumor theranostics with enhanced immunogenic cell death

Journal of Nanobiotechnology, 2021
Background Tumor phototherapy especially photodynamic therapy (PDT) or photothermal therapy (PTT), has been considered as an attractive strategy to elicit significant immunogenic cell death (ICD) at an optimal tumor retention of PDT/PTT agents ...
Ying Tian, Muhammad Rizwan Younis, Yuxia Tang, Xiang Liao, Gang He, Shouju Wang, Zhaogang Teng, Peng Huang, Longjiang Zhang, Guangming Lu   +9 more
doaj   +1 more source

Photothermal and photodynamic activity of polymeric nanoparticles based on α-tocopheryl succinate-RAFT block copolymers conjugated to IR-780. [PDF]

Acta Biomater, 2017
The aim of this work was the generation of a multifunctional nanopolymeric system that incorporates IR-780 dye, a near-infrared (NIR) imaging probe that exhibits photothermal and photodynamic properties; and a derivate of α-tocopheryl succinate (α-TOS), a mitochondria-targeted anticancer compound.
Palao-Suay R, Martín-Saavedra FM, Rosa Aguilar M, Escudero-Duch C, Martín-Saldaña S, Parra-Ruiz FJ, Rohner NA, Thomas SN, Vilaboa N, San Román J.   +9 more
europepmc   +5 more sources

NIR-Laser-Controlled Drug Release from DOX/IR-780-Loaded Temperature-Sensitive-Liposomes for Chemo-Photothermal Synergistic Tumor Therapy. [PDF]

Theranostics, 2016
NIR laser-induced photothermal therapy (PTT) through near-infrared agents has demonstrated the great potential in solid tumor ablation. However, the nonuniform heat distribution over tumors from PTT makes it insufficient to kill all tumor cells, resulting in tumor recurrence and inferior outcomes.
Yan F, Duan W, Li Y, Wu H, Zhou Y, Pan M, Liu H, Liu X, Zheng H.   +8 more
europepmc   +3 more sources

Targeted PLGA–Chitosan Nanoparticles for NIR-Triggered Phototherapy and Imaging of HER2-Positive Tumors

Pharmaceutics, 2023
Targeted medicine uses the distinctive features of cancer cells to find and destroy tumors. We present human epidermal growth factor receptor 2 (HER2)-targeted PLGA–chitosan nanoparticles for cancer therapy and visualization.
Polina A. Kotelnikova, Victoria O. Shipunova, Sergey M. Deyev   +2 more
doaj   +1 more source

Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis

Redox Biology, 2021
Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically compromising lung function and death. However, very little is known about
Ziwen Wang, Long Chen, Yu Huang, Min Luo, Huilan Wang, Zhongyong Jiang, Jiancheng Zheng, Zeyu Yang, Zelin Chen, Chi Zhang, Lei Long, Yawei Wang, Xueru Li, Fengying Liao, Yibo Gan, Peng Luo, Yunsheng Liu, Yu Wang, XuTan, Ziyuan Zhou, Aihua Zhang, Chunmeng Shi   +21 more
doaj   +1 more source