Results 31 to 40 of about 14,770 (158)

Self‐Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic/Photothermal/Chemodynamic/Starvation Therapy for Eradication of Colon Cancer

open access: yesAdvanced Science, EarlyView.
The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang   +11 more
wiley   +1 more source

6–18 M. VAIKŲ REPREZENTACINĖS IR KLINIKINĖS IMČIŲ EMOCINIŲ IR ELGESIO SUNKUMŲ SĄSAJŲ PALYGINIMAS SU ŠEIMOS SOCIALINIAIS, EKONOMINIAIS IR DEMOGRAFINIAIS VEIKSNIAIS

open access: yesPsichologija, 2007
Šio tyrimo tikslas – 6–18 m. vaikų reprezentacinės (N = 3191) ir klinikinės (N = 780) imčių, emocinių ir elgesio sunkumų sąsajų palyginimas su šeimos socialiniais, ekonominiais ir demografiniais veiksniais ir siekis tęsti 2003 m.
Ilona Kajokienė, Rita Žukauskienė
doaj   +1 more source

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

open access: yesAdvanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao   +11 more
wiley   +1 more source

The complete chloroplast genome of Corydalis conspersa

open access: yesMitochondrial DNA. Part B. Resources, 2020
The complete chloroplast genome of Corydalis conspersa was sequenced and assembled. It is a circular form of 187,810 bp in length, which was separated into four distinct regions, a large single-copy (LSC) of 92,280 bp, a small single-copy region (SSC) of
Jiang Wu   +3 more
doaj   +1 more source

Synergistic Effects of Genetic Variants of Glucose Homeostasis and Lifelong Exposures to Cigarette Smoking, Female Hormones, and Dietary Fat Intake on Primary Colorectal Cancer Development in African and Hispanic/Latino American Women

open access: yesFrontiers in Oncology, 2021
BackgroundDisparities in cancer genomic science exist among racial/ethnic minorities. Particularly, African American (AA) and Hispanic/Latino American (HA) women, the 2 largest minorities, are underrepresented in genetic/genome-wide studies for cancers ...
Su Yon Jung   +5 more
doaj   +1 more source

Printable Piezoresistive Hybrid Hydrogels Based on 2D MoS2 for Flexible Pulse Sensing

open access: yesAdvanced Science, EarlyView.
Hybrid 1T‐MoS2‐based hydrogels are engineered through UV curing and 3D printing to achieve tunable electromechanical properties for wearable sensing. These soft architectures enhance mechanical stability and reproducible piezoresistive responses within the physiological pressure range.
Jenny Flores   +18 more
wiley   +1 more source

Pharmaceutical Manipulation of Mitochondrial F0F1‐ATP Synthase Enables Imaging and Protection of Myocardial Ischemia/Reperfusion Injury Through Stress‐induced Selective Enrichment

open access: yesAdvanced Science
To rescue ischemic myocardium from progressing to myocardial infarction, timely identification of the infarct size and reperfusion is crucial. However, fast and accurate identification, as well as the targeted protection of injured cardiomyocytes ...
Zelin Chen   +14 more
doaj   +1 more source

TRPC3‐Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons

open access: yesAdvanced Science, EarlyView.
How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu   +14 more
wiley   +1 more source

Simultaneous enhancement of upconversion luminescence and photoelectric effect in NaYF4:Yb3+/Tm3+/Zr4+ tri-doped microcrystals

open access: yesMaterials Research Express, 2023
β -NaYF _4 : Yb ^3+ /Tm ^3+ /Zr ^4+ microcrystals are synthesized by a facile hydrothermal route. The up-conversion (UC) luminescence and photoelectric effects are enhanced simultaneously with the introduction of Zr ^4+ ions under IR excitation. With the
Bing Liu   +3 more
doaj   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

open access: yesAdvanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen   +13 more
wiley   +1 more source

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