Results 21 to 30 of about 975,688 (225)

Advances in IR-780-derived theranostics: A comparative analysis of free and nanoencapsulated forms

Pharmacological Research
IR-780 is a lipophilic heptamethine cyanine dye that exhibits strong absorption and fluorescence emission in the near-infrared (NIR) region (700–900 nm). Similar to other cyanine dyes, IR-780 is emerging as a promising fluorophore for fluorescence-guided
Michela Marinaro, Irene Paraboschi, Raouf El-Dabl, Laura Privitera, Giulia Lanfranchi, Gloria Pelizzo, Adam Sedgwick, Stefano Giuliani   +7 more
doaj   +3 more sources

Prodrug nanosystem equipped with a sonosensitizer for combined chemotherapy and sonodynamic therapy of melanoma [PDF]

Materials Today Bio
Melanoma is a severe eruptive disease caused by melanocyte lesions and characterized by aggressive tumors, which has become one of the fastest evolving cancers worldwide, and its incidence and mortality rates have shown larger increases than other types ...
Ying Wang, Yujie Wang, Yao Yang, Ling Leng   +3 more
doaj   +3 more sources

IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice. [PDF]

Acta Pharmacol Sin, 2018
Cancer metastasis is responsible for over 90% of breast cancer-related deaths, and inhibiting lymph node metastasis is an option to treat metastatic disease. Herein, we report the use of IR-780-loaded polymeric micelles (IPMs) for effective photothermal therapy (PTT) of breast cancer lymphatic metastasis.
He B, Hu HY, Tan T, Wang H, Sun KX, Li YP, Zhang ZW.   +6 more
europepmc   +5 more sources

Biomimetic cell membrane decorated ZIF‐8 nanocarriers with IR‐780 and doxorubicin loading for multiple myeloma treatment

Aggregate
Several therapeutic drugs including heptamethine cyanine dye (IR‐780), doxorubicin (DOX), and others have exhibited positive outcomes in the treatment of multiple myeloma (MM).
Guangtao Gao, Junyi Che, Peipei Xu, Bing Chen, Yuanjin Zhao   +4 more
doaj   +3 more sources

Developing IR-780 as a Novel Matrix for Enhanced MALDI MS Imaging of Endogenous High-Molecular-Weight Lipids in Brain Tissues

Analytical Chemistry, 2019
The matrix plays a prominent role in expanding the ability of matrix assisted laser desorption/ionization mass spectrometry (MALDI MS). However, on account of the unclarity of necessary properties of the matrix in MALDI MS, development of a new matrix is still in the exploratory stage and lacks systematic theoretical guidance.
Na Li, Peng Wang, Xiaolong Liu, Chao Han, Wei Ren, Tuo Li, Xing Li, Fengyun Tao, Zhenwen Zhao   +8 more
semanticscholar   +4 more sources

NIR-Laser-Controlled Drug Release from DOX/IR-780-Loaded Temperature-Sensitive-Liposomes for Chemo-Photothermal Synergistic Tumor Therapy. [PDF]

Theranostics, 2016
NIR laser-induced photothermal therapy (PTT) through near-infrared agents has demonstrated the great potential in solid tumor ablation. However, the nonuniform heat distribution over tumors from PTT makes it insufficient to kill all tumor cells ...
Yan F, Duan W, Li Y, Wu H, Zhou Y, Pan M, Liu H, Liu X, Zheng H.   +8 more
europepmc   +2 more sources

Labeling Stem Cells with a Near-Infrared Fluorescent Heptamethine Dye for Noninvasive Optical Tracking

Cell Transplantation, 2011
Near-infrared (NIR) fluorescent agents hold great promise for noninvasive in vivo imaging. We have recently reported that a NIR fluorescent heptamethine dye, IR-780 iodide, exhibits unique optical properties for biomedical imaging.
Chao Zhang, Xu Tan, Li Tan, Tao Liu, Dengqun Liu, Lilong Zhang, Song Fan, Yongping Su, Tianmin Cheng, Yue Zhou, Chunmeng Shi   +10 more
doaj   +2 more sources

Drug retention after intradiscal administration [PDF]

Drug Delivery
Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention.
Imke Rudnik-Jansen, Jie Du, Nina Karssemakers-Degen, Anna R. Tellegen, Parvesh Wadhwani, Daniele Zuncheddu, Björn P. Meij, Jens Thies, Pieter Emans, Fetullah C. Öner, George Mihov, Joao Pedro Garcia, Anne S. Ulrich, Sibylle Grad, Marianna A. Tryfonidou, Hugo van Ingen, Laura B. Creemers   +16 more
doaj   +5 more sources

Targeted PLGA–Chitosan Nanoparticles for NIR-Triggered Phototherapy and Imaging of HER2-Positive Tumors

Pharmaceutics, 2023
Targeted medicine uses the distinctive features of cancer cells to find and destroy tumors. We present human epidermal growth factor receptor 2 (HER2)-targeted PLGA–chitosan nanoparticles for cancer therapy and visualization.
Polina A. Kotelnikova, Victoria O. Shipunova, Sergey M. Deyev   +2 more
doaj   +2 more sources

NEAR-INFRARED DYE IR-780 ALLEVIATES HEMATOPOIETIC SYSTEM DAMAGE BY PROMOTING HEMATOPOIETIC STEM CELLS INTO QUIESCENCE

Shock
ABSTRACT Potential radiation exposure is a general concern, but there still lacks radioprotective countermeasures. Here, we found a small molecular near-infrared dye IR-780, which promoted hematopoietic stem cells (HSCs) into quiescence to resist stress.
Jie, Wu, Le, Ma, Qiang, Gong, Yan, Chen, Long, Chen, Chunmeng, Shi   +5 more
openaire   +3 more sources