Results 11 to 20 of about 14,770 (158)

Targeted PLGA–Chitosan Nanoparticles for NIR-Triggered Phototherapy and Imaging of HER2-Positive Tumors

Pharmaceutics, 2023
Targeted medicine uses the distinctive features of cancer cells to find and destroy tumors. We present human epidermal growth factor receptor 2 (HER2)-targeted PLGA–chitosan nanoparticles for cancer therapy and visualization.
Polina A. Kotelnikova, Victoria O. Shipunova, Sergey M. Deyev   +2 more
doaj   +1 more source

Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis

Redox Biology, 2021
Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically compromising lung function and death. However, very little is known about
Ziwen Wang, Long Chen, Yu Huang, Min Luo, Huilan Wang, Zhongyong Jiang, Jiancheng Zheng, Zeyu Yang, Zelin Chen, Chi Zhang, Lei Long, Yawei Wang, Xueru Li, Fengying Liao, Yibo Gan, Peng Luo, Yunsheng Liu, Yu Wang, XuTan, Ziyuan Zhou, Aihua Zhang, Chunmeng Shi   +21 more
doaj   +1 more source

Biomimetic biomineralization nanoplatform-mediated differentiation therapy and phototherapy for cancer stem cell inhibition and antitumor immunity activation

Asian Journal of Pharmaceutical Sciences, 2023
Growing evidence suggests that the presence of cancer stem cells (CSCs) is a major challenge in current tumor treatments, especially the transition from non-CSCs to differentiation of CSCs for evading conventional therapies and driving metastasis.
Shan Gao, Meng Liu, Dongzhu Liu, Xinru Kong, Yuelin Fang, Yingying Li, Hang Wu, Jianbo Ji, Xiaoye Yang, Guangxi Zhai   +9 more
doaj   +1 more source

Tunable visible comb using Raman self-frequency shift, intermodal phase matching and cascading of nonlinearities in an all-fiber platform

Physical Review Research, 2023
Up-conversion of IR frequency combs from compact erbium fiber mode-locked lasers (MLLs) around 1550 nm is enabling the development of small-footprint visible combs for ultralow-power spectroscopy and quantum optics. Limited tunability of the IR MLLs, due
Akhileshwar Mishra, Seth Mathew V, Ravi Pant   +2 more
doaj   +1 more source

Immunogenic Cell Death Photothermally Mediated by Erythrocyte Membrane-Coated Magnetofluorescent Nanocarriers Improves Survival in Sarcoma Model

Pharmaceutics, 2023
Inducing immunogenic cell death (ICD) during cancer therapy is a major challenge that might significantly improve patient survival. The purpose of this study was to develop a theranostic nanocarrier, capable both of conveying a cytotoxic thermal dose ...
Ailton Antonio Sousa-Junior, Francyelli Mello-Andrade, João Victor Ribeiro Rocha, Tácio Gonçalves Hayasaki, Juliana Santana de Curcio, Lívia do Carmo Silva, Ricardo Costa de Santana, Eliana Martins Lima, Cléver Gomes Cardoso, Elisângela de Paula Silveira-Lacerda, Sebastião Antonio Mendanha, Andris Figueiroa Bakuzis   +11 more
doaj   +1 more source

Optimization of Near-Infrared Fluorescence Voltage-Sensitive Dye Imaging for Neuronal Activity Monitoring in the Rodent Brain

Frontiers in Neuroscience, 2021
Many currently employed clinical brain functional imaging technologies rely on indirect measures of activity such as hemodynamics resulting in low temporal and spatial resolutions.
Rebecca W. Pak, Jeeun Kang, Emad Boctor, Jin U. Kang   +3 more
doaj   +1 more source

Long‐Term High Level of Insulin Resistance Is Associated With an Increased Prevalence of Coronary Artery Calcification: The CARDIA Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Coronary artery calcification (CAC) is a crucial indicator of subclinical atherosclerotic cardiovascular disease. The relationship between long‐term insulin resistance (IR) trajectory and CAC has been explored in few studies.
Zezhi Ke, Rihua Huang, Xinghao Xu, Wenbin Liu, Suisui Wang, Xu Zhang, Ye Guo, Xiaodong Zhuang, Liao Zhen   +8 more
doaj   +1 more source

Labeling Stem Cells with a Near-Infrared Fluorescent Heptamethine Dye for Noninvasive Optical Tracking

Cell Transplantation, 2011
Near-infrared (NIR) fluorescent agents hold great promise for noninvasive in vivo imaging. We have recently reported that a NIR fluorescent heptamethine dye, IR-780 iodide, exhibits unique optical properties for biomedical imaging.
Chao Zhang, Xu Tan, Li Tan, Tao Liu, Dengqun Liu, Lilong Zhang, Song Fan, Yongping Su, Tianmin Cheng, Yue Zhou, Chunmeng Shi   +10 more
doaj   +1 more source

Mitochondria-Targeting Immunogenic Cell Death Inducer Improves the Adoptive T-Cell Therapy Against Solid Tumor

Frontiers in Oncology, 2019
Cancer immunotherapy including adoptive T cell therapy (ACT) is widely used in the clinic and is highly beneficial for patients with hematological malignancies; however, it remains a challenge to develop effective immunotherapy strategies for the ...
Qingzhi Jiang, Qingzhi Jiang, Chi Zhang, Huilan Wang, Huilan Wang, Tao Peng, Li Zhang, Yang Wang, Weidong Han, Chunmeng Shi, Chunmeng Shi   +10 more
doaj   +1 more source

NIR diagnostic imaging of triple-negative breast cancer and its lymph node metastasis for high-efficiency hypoxia-activated multimodal therapy

Journal of Nanobiotechnology, 2023
Background Triple-negative breast cancer (TNBC) possesses special biological behavior and clinicopathological characteristics, which is highly invasive and propensity to metastasize to lymph nodes, leading to a worse prognosis than other types of breast ...
Yi Pan, Longcai Liu, Yichen He, Luyi Ye, Xin Zhao, Zhiming Hu, Xiaozhou Mou, Yu Cai   +7 more
doaj   +1 more source