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Intravesical IR‐780 instillation prevents radiation cystitis by protecting urothelial integrity

Neurourology and Urodynamics, 2022
AbstractPurposeTo explore an efficient preventive strategy for radiation cystitis.MethodsWe instilled IR‐780 into the bladders of rats 1 h before bladder irradiation, and its bio‐distribution was observed at different times. Bladders were then examined for pathogenic alterations and inflammation levels by day 3 and week 12 postirradiation, and the ...
Jinjin Li   +11 more
openaire   +2 more sources

Mitochondrial-targeting fluorescent small molecule IR-780 alleviates radiation-induced brain injury

Brain Research, 2023
Radiation-induced brain injury (RIBI) is a common complication of radiation therapy for brain tumors. Vascular damage is one of the key factors closely related to the severity of the RIBI. However, effective vascular target treatment strategies are lacking.
Can, Zhang   +9 more
openaire   +2 more sources

Mitigation of radiation-induced pulmonary fibrosis by small-molecule dye IR-780

Free Radical Biology and Medicine, 2021
Radiation-induced pulmonary fibrosis (RIPF) is a common complication during thoracic radiotherapy, but there are few effective treatments. Here, we identify IR-780, a mitochondria-targeted near-infrared (NIR) dye, can selectively accumulate in the irradiated lung tissues.
Min Luo   +16 more
openaire   +2 more sources

FRET in a Polymeric Nanocarrier: IR-780 and IR-780-PDMS

Biomacromolecules, 2019
We introduce a method to monitor the integrity of micellar nanocarriers using a novel fluorescent dye, IR-780-PDMS and Förster resonance energy transfer (FRET) as a readout. In addition, these dye-loaded nanocarriers can be used as a phototoxic agent in vitro. Mainly, a nanocarrier was designed, based on a previously described amphiphilic ABA-copolymer
Marc P. Wolf   +3 more
openaire   +2 more sources

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