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Mitigation of radiation-induced pulmonary fibrosis by small-molecule dye IR-780

Free Radical Biology and Medicine, 2021
Radiation-induced pulmonary fibrosis (RIPF) is a common complication during thoracic radiotherapy, but there are few effective treatments. Here, we identify IR-780, a mitochondria-targeted near-infrared (NIR) dye, can selectively accumulate in the irradiated lung tissues.
Min Luo, Yu Huang, Chi Zhang
exaly   +3 more sources

Intravesical IR‐780 instillation prevents radiation cystitis by protecting urothelial integrity

Neurourology and Urodynamics, 2022
AbstractPurposeTo explore an efficient preventive strategy for radiation cystitis.MethodsWe instilled IR‐780 into the bladders of rats 1 h before bladder irradiation, and its bio‐distribution was observed at different times. Bladders were then examined for pathogenic alterations and inflammation levels by day 3 and week 12 postirradiation, and the ...
Jinjin Li   +11 more
openaire   +2 more sources

Mitochondrial-targeting fluorescent small molecule IR-780 alleviates radiation-induced brain injury

Brain Research, 2023
Radiation-induced brain injury (RIBI) is a common complication of radiation therapy for brain tumors. Vascular damage is one of the key factors closely related to the severity of the RIBI. However, effective vascular target treatment strategies are lacking.
Can, Zhang   +9 more
openaire   +2 more sources

AIEgens Conjugation Improves the Photothermal Efficacy and Near-Infrared Imaging of Heptamethine Cyanine IR-780

ACS Applied Materials & Interfaces, 2020
Near-infrared (NIR) fluorescent probes can deeply penetrate through tissues with little damage. To facilitate image-guided theranostics, researchers usually apply a desired amount of photosensitizers to achieve effective photothermal responses. However, these probes could easily suffer from low photostability and aggregated-caused quenching effect in ...
Xiujie Zhao, Shuo Wang, Jie Yang
exaly   +3 more sources

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