Results 171 to 180 of about 13,867 (204)

FRET in a Polymeric Nanocarrier: IR-780 and IR-780-PDMS

Biomacromolecules, 2019
We introduce a method to monitor the integrity of micellar nanocarriers using a novel fluorescent dye, IR-780-PDMS and Förster resonance energy transfer (FRET) as a readout. In addition, these dye-loaded nanocarriers can be used as a phototoxic agent in vitro. Mainly, a nanocarrier was designed, based on a previously described amphiphilic ABA-copolymer
Marc P. Wolf, Kegang Liu, Thomas F. W. Horn, Patrick Hunziker   +3 more
openaire   +3 more sources

IR 780-loaded hyaluronic acid micelles for enhanced tumor-targeted photothermal therapy

Carbohydrate Polymers, 2018
In this study, we propose using IR 780-loaded, CD44-targeted hyaluronic acid-based micelles (HA-IR 780) for enhanced photothermal therapy (PTT) effects in tumors. Two kinds of HA-C18 micelles were synthesized from different C18 feed ratios with degree of substitution of 3% and 13% respectively.
Saji, Uthaman, Ansuja Pulickal, Mathew, Hyeong Ju, Park, Byeong-Il, Lee, Hyung-Seok, Kim, Kang Moo, Huh, In-Kyu, Park   +6 more
openaire   +2 more sources

Design, synthesis and application of near-infrared fluorescence probe IR-780-Crizotinib in detection of ALK positive tumors

Protein Expression and Purification, 2021
At present, the early diagnosis and treatment of NSCLC has become an international research hotspot. However, how to realize the organic combination of highly sensitive and high-resolution tumor imaging diagnosis and effective treatment, and to provide effective information for the diagnosis and treatment of cancer is still a major problem in the ...
Jiaolong, Wang, Chunlong, Sun, Min, Ji, Baoqin, Wang, Peng, Wang, Gaoxin, Zhou, Bin, Dong, Wen, Du, Li, Huang, Hongguo, Wang, Lili, Ren   +10 more
openaire   +2 more sources

Cyanine IR-780 for distinguishing 2-amino thiophenols from position isomers

Dyes and Pigments, 2016
Abstract Developing highly selective fluorescent probes for the determination of thiophenol is very significant due to its toxicity influence in biological system. In this work, we firstly found that the commercial available cyanine dye 3H-Indolium, 2-(2-(2-chloro-3-(2-(1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1 ...
Xiaole Sheng, Zhilan Ye, Shenghua Liu, Wenshan He, Jinghua Ren, Jun Yin   +5 more
openaire   +1 more source

IR-780 dye can be used as a sonodynamic agent against breast tumor

2015 IEEE International Ultrasonics Symposium (IUS), 2015
Sonodynamic therapy (SDT) is developing as a new modality for cancer therapy through activating certain chemical sensitizers by ultrasound. The aim of this work was to introduce IR-780 iodide, a lipophilic cation heptamethine dye with peak absorption at 780 nm, as SDT agents for breast cancer treatment. The in vitro cellular uptake, cell viability, and
null Fei Yan, null Yekuo Li, null Zhiting Deng, null Hairong Zheng   +3 more
openaire   +1 more source

Bio-nanoconjugates of lithocholic acid/IR 780 for ROS-mediated apoptosis and optoacoustic imaging applications in breast cancer

Colloids and Surfaces B: Biointerfaces, 2023
A new lithocholic acid/IR 780 conjugate (LIC) was designed and synthesized for theranostic applications in triple-negative breast cancer. Lithocholic acid is an antitumor biomacromolecule and acts via multiple molecular targets. IR 780 iodide is a fluorescent NIR organic dye researched as a photothermal agent in cancer therapy.
Aparajita Ghosh, Bishal Rajdev, Nidhi Parihar, Srikanth Ponneganti, Pintu Das, V.G.M. Naidu, P. Radha Krishnanand, U.S.N. Murty, Jagadeesh Kumar, Deepak B. Pemmaraju   +9 more
openaire   +2 more sources

IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy

Biomaterials, 2013
IR-780 iodide is a near-infrared (NIR) fluorescence dye with higher and more stable fluorescence intensity than clinically applied dye indocyanine green (ICG). Meanwhile, IR-780 can be utilized in photothermal therapy with laser irradiation. IR-780 is an important theranostic agent but its lipophilicity limited its application.
Caixia, Yue, Peng, Liu, Mingbin, Zheng, Pengfei, Zhao, Yiqing, Wang, Yifan, Ma, Lintao, Cai   +6 more
openaire   +2 more sources

Photostability Highly Improved Nanoparticles Based on IR-780 and Negative Charged Copolymer for Enhanced Photothermal Therapy

ACS Biomaterials Science & Engineering, 2018
The development of near-infrared (NIR) dyes with desirable photophysical characteristics for tumor therapy is highly expected at present. In this report, IR-780 iodide was loaded by the mercaptopropionic acid grafted poly(ethylene glycol)-block-poly(ε-caprolactone)-block-poly(allyl glycidyl ether) [mPEG5K-PCL10K-PAGE6 (MPA)] copolymer to form ...
Nannan Shao, Yanxin Qi, Hongtong Lu, Dongyun He, Bin Li, Yubin Huang   +5 more
openaire   +2 more sources

IR-780-Albumin-Based Nanocarriers Promote Tumor Regression Not Only from Phototherapy but Also by a Nonirradiation Mechanism

ACS Biomaterials Science & Engineering, 2020
IR-780 iodide is a fluorescent dye with optical properties in the near-infrared region that has applications in tumor detection and photothermal/photodynamic therapy. This multifunctional effect led to the development of theranostic nanoparticles with both IR-780 and chemotherapeutic drugs such as docetaxel, doxorubicin, and lonidamine.
Gustavo Capistrano, Ailton A. Sousa-Junior, Roosevelt A. Silva, Francyelli Mello-Andrade, Emilio R. Cintra, Sônia Santos, Allancer D. Nunes, Raisa M. Lima, Nicholas Zufelato, André S. Oliveira, Maristela Pereira, Carlos H. Castro, Eliana M. Lima, Clever G. Cardoso, Elisângela Silveira-Lacerda, Sebastião A. Mendanha, Andris F. Bakuzis   +16 more
openaire   +2 more sources

Mitochondria‐Targeting IR‐780 Dye and Its Derivatives: Synthesis, Mechanisms of Action, and Theranostic Applications

Advanced Therapeutics, 2018
AbstractMitochondria are important targets in diverse physiological and pathological conditions associated with cell survival and death. The characterization of mitochondria‐targeting agents is highly useful to the understanding of mitochondrial functions and the development of targeted therapeutic strategies. IR‐780, a prototypical near‐infrared (NIR)
Chi Zhang, Lei Long, Chunmeng Shi
openaire   +1 more source