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Mitigation of radiation-induced pulmonary fibrosis by small-molecule dye IR-780
Free Radical Biology and Medicine, 2021Radiation-induced pulmonary fibrosis (RIPF) is a common complication during thoracic radiotherapy, but there are few effective treatments. Here, we identify IR-780, a mitochondria-targeted near-infrared (NIR) dye, can selectively accumulate in the irradiated lung tissues.
Yu Huang, Aihua Zhang, Shiqian Han
exaly +3 more sources
Mechanistic study of IR-780 dye as a potential tumor targeting and drug delivery agent
Biomaterials, 2014IR-780 iodide, a near-infrared fluorescent heptamethine dye, has been recently characterized to exhibit preferential accumulation property in the mitochondria of tumor cells. In this study, we investigated the possible mechanisms for its tumor selective activity and its potential as a drug delivery carrier.
Shenglin Luo +2 more
exaly +3 more sources
ACS Applied Materials & Interfaces, 2020
Near-infrared (NIR) fluorescent probes can deeply penetrate through tissues with little damage. To facilitate image-guided theranostics, researchers usually apply a desired amount of photosensitizers to achieve effective photothermal responses. However, these probes could easily suffer from low photostability and aggregated-caused quenching effect in ...
Yongmei Yin, Jie Yang, Shuo Wang
exaly +3 more sources
Near-infrared (NIR) fluorescent probes can deeply penetrate through tissues with little damage. To facilitate image-guided theranostics, researchers usually apply a desired amount of photosensitizers to achieve effective photothermal responses. However, these probes could easily suffer from low photostability and aggregated-caused quenching effect in ...
Yongmei Yin, Jie Yang, Shuo Wang
exaly +3 more sources
Biomaterials, 2014
Personalized oncology significantly relies on the development of theranostic agents to integrate cancer therapeutics and diagnostics. Current strategy for development of such multifunctional agents requires multistep chemical conjugation with cancer specific ligands, contrast agents and therapeutic drugs. In this study, we reported a near infrared (NIR)
Shenglin Luo +2 more
exaly +3 more sources
Personalized oncology significantly relies on the development of theranostic agents to integrate cancer therapeutics and diagnostics. Current strategy for development of such multifunctional agents requires multistep chemical conjugation with cancer specific ligands, contrast agents and therapeutic drugs. In this study, we reported a near infrared (NIR)
Shenglin Luo +2 more
exaly +3 more sources
ACS Applied Materials & Interfaces, 2016
IR-780 iodide, a near-infrared (near-IR) fluorescent dye, can be utilized as an effective theranostic agent for both imaging and photothermal therapy. However, its lipophilicity limits its further biomedical applications. Herein, we synthesized a phospholipid mimicking amphiphilic homopolymer poly(12-(methacryloyloxy)dodecyl phosphorylcholine) (PMDPC ...
Haibo Wang, Yin Wang, Jian Ji
exaly +3 more sources
IR-780 iodide, a near-infrared (near-IR) fluorescent dye, can be utilized as an effective theranostic agent for both imaging and photothermal therapy. However, its lipophilicity limits its further biomedical applications. Herein, we synthesized a phospholipid mimicking amphiphilic homopolymer poly(12-(methacryloyloxy)dodecyl phosphorylcholine) (PMDPC ...
Haibo Wang, Yin Wang, Jian Ji
exaly +3 more sources
ACS Applied Materials & Interfaces, 2017
This is high demand to enhance the accumulation of near-infrared theranostic agents in the tumor region, which is favorable to the effective phototherapy. Compared with indocyanine green (a clinically applied dye), IR-780 iodide possesses higher and more stable fluorescence intensity and can be utilized as an imaging-guided PTT agent with laser ...
Ye Kuang, Yi Cao, Xing Chen
exaly +3 more sources
This is high demand to enhance the accumulation of near-infrared theranostic agents in the tumor region, which is favorable to the effective phototherapy. Compared with indocyanine green (a clinically applied dye), IR-780 iodide possesses higher and more stable fluorescence intensity and can be utilized as an imaging-guided PTT agent with laser ...
Ye Kuang, Yi Cao, Xing Chen
exaly +3 more sources
Intravesical IR‐780 instillation prevents radiation cystitis by protecting urothelial integrity
Neurourology and Urodynamics, 2022AbstractPurposeTo explore an efficient preventive strategy for radiation cystitis.MethodsWe instilled IR‐780 into the bladders of rats 1 h before bladder irradiation, and its bio‐distribution was observed at different times. Bladders were then examined for pathogenic alterations and inflammation levels by day 3 and week 12 postirradiation, and the ...
Jinjin Li +11 more
openaire +2 more sources
Photochemistry and Photobiology, 2021
AbstractIR‐780 is a lipophilic dye with excellent optical and tumor imaging properties for early tumor diagnostics. Although the mechanism of tumor targeting has not been fully identified, the view that serum albumin plays an important role in tumor accumulation has been recognized.
Lei Long +5 more
openaire +2 more sources
AbstractIR‐780 is a lipophilic dye with excellent optical and tumor imaging properties for early tumor diagnostics. Although the mechanism of tumor targeting has not been fully identified, the view that serum albumin plays an important role in tumor accumulation has been recognized.
Lei Long +5 more
openaire +2 more sources
Mitochondrial-targeting fluorescent small molecule IR-780 alleviates radiation-induced brain injury
Brain Research, 2023Radiation-induced brain injury (RIBI) is a common complication of radiation therapy for brain tumors. Vascular damage is one of the key factors closely related to the severity of the RIBI. However, effective vascular target treatment strategies are lacking.
Can, Zhang +9 more
openaire +2 more sources
Small, 2022
AbstractIn spite of efforts to fabricate self‐assembled energy storage nanopaper with potential applications in displays, greenhouses, and sensors, few studies have investigated their multiple stimuli‐sensitivities. Here, an opto‐ and thermal‐rewrite phase change material/cellulose nanofibril (PCM/CNF) energy storage nanopaper with mechanical regulated
Jin Liu +7 more
openaire +3 more sources
AbstractIn spite of efforts to fabricate self‐assembled energy storage nanopaper with potential applications in displays, greenhouses, and sensors, few studies have investigated their multiple stimuli‐sensitivities. Here, an opto‐ and thermal‐rewrite phase change material/cellulose nanofibril (PCM/CNF) energy storage nanopaper with mechanical regulated
Jin Liu +7 more
openaire +3 more sources