Results 211 to 220 of about 14,237 (239)

Design, synthesis and application of near-infrared fluorescence probe IR-780-Crizotinib in detection of ALK positive tumors

Protein Expression and Purification, 2021
At present, the early diagnosis and treatment of NSCLC has become an international research hotspot. However, how to realize the organic combination of highly sensitive and high-resolution tumor imaging diagnosis and effective treatment, and to provide effective information for the diagnosis and treatment of cancer is still a major problem in the ...
Jiaolong, Wang, Chunlong, Sun, Min, Ji, Baoqin, Wang, Peng, Wang, Gaoxin, Zhou, Bin, Dong, Wen, Du, Li, Huang, Hongguo, Wang, Lili, Ren   +10 more
openaire   +2 more sources

Bio-nanoconjugates of lithocholic acid/IR 780 for ROS-mediated apoptosis and optoacoustic imaging applications in breast cancer

Colloids and Surfaces B: Biointerfaces, 2023
A new lithocholic acid/IR 780 conjugate (LIC) was designed and synthesized for theranostic applications in triple-negative breast cancer. Lithocholic acid is an antitumor biomacromolecule and acts via multiple molecular targets. IR 780 iodide is a fluorescent NIR organic dye researched as a photothermal agent in cancer therapy.
Aparajita Ghosh, Bishal Rajdev, Nidhi Parihar, Srikanth Ponneganti, Pintu Das, V.G.M. Naidu, P. Radha Krishnanand, U.S.N. Murty, Jagadeesh Kumar, Deepak B. Pemmaraju   +9 more
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IR-780 dye can be used as a sonodynamic agent against breast tumor

2015 IEEE International Ultrasonics Symposium (IUS), 2015
Sonodynamic therapy (SDT) is developing as a new modality for cancer therapy through activating certain chemical sensitizers by ultrasound. The aim of this work was to introduce IR-780 iodide, a lipophilic cation heptamethine dye with peak absorption at 780 nm, as SDT agents for breast cancer treatment. The in vitro cellular uptake, cell viability, and
null Fei Yan, null Yekuo Li, null Zhiting Deng, null Hairong Zheng   +3 more
openaire   +1 more source

Preferential accumulation of the near infrared heptamethine dye IR-780 in the mitochondria of drug-resistant lung cancer cells

Biomaterials, 2014
Personalized oncology significantly relies on the development of theranostic agents to integrate cancer therapeutics and diagnostics. Current strategy for development of such multifunctional agents requires multistep chemical conjugation with cancer specific ligands, contrast agents and therapeutic drugs. In this study, we reported a near infrared (NIR)
Erlong Zhang, Shenglin Luo, Chunmeng Shi
exaly   +3 more sources

IR-780-Albumin-Based Nanocarriers Promote Tumor Regression Not Only from Phototherapy but Also by a Nonirradiation Mechanism

ACS Biomaterials Science & Engineering, 2020
IR-780 iodide is a fluorescent dye with optical properties in the near-infrared region that has applications in tumor detection and photothermal/photodynamic therapy. This multifunctional effect led to the development of theranostic nanoparticles with both IR-780 and chemotherapeutic drugs such as docetaxel, doxorubicin, and lonidamine.
Gustavo Capistrano, Ailton A. Sousa-Junior, Roosevelt A. Silva, Francyelli Mello-Andrade, Emilio R. Cintra, Sônia Santos, Allancer D. Nunes, Raisa M. Lima, Nicholas Zufelato, André S. Oliveira, Maristela Pereira, Carlos H. Castro, Eliana M. Lima, Clever G. Cardoso, Elisângela Silveira-Lacerda, Sebastião A. Mendanha, Andris F. Bakuzis   +16 more
openaire   +2 more sources

Photostability Highly Improved Nanoparticles Based on IR-780 and Negative Charged Copolymer for Enhanced Photothermal Therapy

ACS Biomaterials Science & Engineering, 2018
The development of near-infrared (NIR) dyes with desirable photophysical characteristics for tumor therapy is highly expected at present. In this report, IR-780 iodide was loaded by the mercaptopropionic acid grafted poly(ethylene glycol)-block-poly(ε-caprolactone)-block-poly(allyl glycidyl ether) [mPEG5K-PCL10K-PAGE6 (MPA)] copolymer to form ...
Nannan Shao, Yanxin Qi, Hongtong Lu, Dongyun He, Bin Li, Yubin Huang   +5 more
openaire   +2 more sources

Mitochondria‐Targeting IR‐780 Dye and Its Derivatives: Synthesis, Mechanisms of Action, and Theranostic Applications

Advanced Therapeutics, 2018
AbstractMitochondria are important targets in diverse physiological and pathological conditions associated with cell survival and death. The characterization of mitochondria‐targeting agents is highly useful to the understanding of mitochondrial functions and the development of targeted therapeutic strategies. IR‐780, a prototypical near‐infrared (NIR)
Chi Zhang, Lei Long, Chunmeng Shi
openaire   +1 more source

The near-infrared fluorescent dye IR-780 was coupled with cabazitaxel for castration-resistant prostate cancer imaging and therapy

Investigational New Drugs, 2020
A new drug, Caba-780, was synthesized by chemical coupling of the heptamethyl phthalocyanine near-infrared fluorescent (NIRF) dye IR-780 and the paclitaxel-based chemotherapeutic drug cabazitaxel. Then, the potential value of Caba-780 in the diagnosis and treatment of castration-resistant prostate cancer (CRPC) was evaluated.
Yu, Zheng, Guangdong, Hou, Geng, Zhang, Ting, Lan, Jiarui, Yuan, Lei, Zhang, Fei, Yan, Fuli, Wang, Ping, Meng, Xinlong, Dun, Xi'an, Li, Guo, Chen, Zheng, Zhu, Di, Wei, Wei, He, Jianlin, Yuan   +15 more
openaire   +2 more sources

Water Soluble IR-780 Polymer for Mitochondria-Targeted Photodynamic Therapy^※

Acta Chimica Sinica, 2022
Zhaohui Tang, Zigui Wang, Yanran Li
openaire   +1 more source

Electroporation and lipid nanoparticles with cyanine IR-780 and flavonoids as efficient vectors to enhanced drug delivery in colon cancer

Bioelectrochemistry, 2016
Nanocarriers and electroporation (also named electropermeabilization) are convenient methods to increase drug transport. In the current study, we present an effective support of drug delivery into cancer cells, utilizing these methods. We compare the efficiency of each of them and their combination.
Julita Kulbacka, Agata Pucek, Małgorzata Kotulska, Magda Dubińska-Magiera, Joanna Rossowska, Marie-Pierre Rols, Kazimiera Anna Wilk   +6 more
openaire   +2 more sources