Results 141 to 150 of about 1,216 (154)

Uncovering cell cycle-dependent effects on cell survival in near-infrared photoimmunotherapy. [PDF]

open access: yesExp Cell Res
Kaida A   +7 more
europepmc   +1 more source

Carbonic anhydrase-9-targeted near-infrared photoimmunotherapy as a theranostic modality for clear cell renal cell carcinoma. [PDF]

open access: yesInt J Cancer
Fukushima H   +13 more
europepmc   +1 more source

Fluorescence Imaging of Tumor-Accumulating Antibody-IR700 Conjugates Prior to Near-Infrared Photoimmunotherapy (NIR-PIT) Using a Commercially Available Camera Designed for Indocyanine Green

Molecular Pharmaceutics, 2021
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer treatment that uses antibody-IRDye700DX (IR700) conjugates and was recently approved in Japan for patients with inoperable head and neck cancer. Exposure of the tumor with NIR light at a wavelength of 690 nm leads to physicochemical changes in the antibody-IR700 conjugate-cell ...
Hiroaki Wakiyama   +2 more
exaly   +3 more sources

Elimination of cells deviated from human induced pluripotent stem cells with a photoactivatable IR700-labelled antibody

Biochemical and Biophysical Research Communications, 2021
Human induced pluripotent stem cells (hiPSCs) are important starting materials for cell therapy products (CTPs) used for transplantation. During cell culture, hiPSCs often spontaneously undergo morphological changes and lose pluripotency. Such cells are called 'deviated cells', which are deviated from the undifferentiated state of hiPSCs, lack the ...
Tomoko Watanabe, Hiroaki Tateno
exaly   +3 more sources

Development of anti-cadherin-17 antibody -IR700 conjugate for photodynamic therapy against gastrointestinal cancers

17th International Photodynamic Association World Congress, 2019
The lack of tumor specificity by photosensitizers often hampers the clinical application of photodynamic therapy (PDT). Delivery of photosensitizer to tumor based entirely on the enhanced permeability and retention effect could lead to nonspecific uptake of photosensitizer by normal tissue, causing adverse effect in patients.
Dennis Ng, Wing-Ping Fong, John M Luk
exaly   +2 more sources

Dose-dependent effect of dinutuximab-IR700 photoimmunotherapy on GD2-expressing tumors.

Journal of Clinical Oncology
e14556 Background: Near-infrared photoimmunotherapy (PIT) is a novel, molecularly targeted cancer therapy. It combines tumor-directed immunotherapy agents with a phthalocyanine dye IR700 to induce rapid cell death upon light activation, while sparing ...
Constantinos Hadjipanayis   +1 more
exaly   +2 more sources

Real-time IR700 Fluorescence Imaging During Near-infrared Photoimmunotherapy Using a Clinically-approved Camera for Indocyanine Green

Cancer Diagnosis & Prognosis, 2021
Background/Aim: Near-infrared photoimmuno-therapy (NIR-PIT) is a newly approved cancer phototherapy. We aim to confirm whether a clinically approved camera for indocyanine green (ICG) could monitor IR700 fluorescence in real time during exposure to therapeutic NIR light.
Shuhei, Okuyama   +9 more
openaire   +2 more sources

Abstract 2484: IR700-conjugated anti-CD44 monoclonal antibody for phototherapy theranostics of triple-negative breast cancer

Cancer Research, 2015
Abstract CD44 transmembrane glycoproteins are cell adhesion molecules that play a role in cancer cell proliferation, migration, and invasion.1 CD44 expression is associated with stem-like breast cancer cells1 and is upregulated under hypoxia2 making it a significant target.
Jiefu Jin   +3 more
openaire   +1 more source

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