Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration [PDF]
, 2023 Unchecked, chronic inflammation is a constitutive component of age-related diseases, including age-related macular degeneration (AMD). Here we identified interleukin-1 receptor-associated kinase (IRAK)-M as a key immunoregulator in retinal pigment ...
Bell, Oliver H +23 more
core
Microorganisms, 2021 Staphylococcus aureus inhibits complement activity by secreting a variety of toxins. However, the underlying mechanism of complement component regulation by lipoteichoic acid (LTA), a cell wall component of S. aureus, has not been elucidated.
Bong Jun Jung +4 more
doaj +1 more source
Activator protein 1 promotes the transcriptional activation of IRAK-M
Biomedicine & Pharmacotherapy, 2016 Interleukin-1 receptor-associated kinase M (IRAK-M) is a well-known negative regulator for Toll-like receptor signaling, which can regulate immune homeostasis and tolerance in a number of pathological settings. However, the mechanism for IRAK-M regulation at transcriptional level remains largely unknown.
Peipei, Jin +6 more
openaire +2 more sources
IRAK-M Is Involved in the Pathogenesis of Early-Onset Persistent Asthma [PDF]
The American Journal of Human Genetics, 2007 Asthma is a multifactorial disease influenced by genetic and environmental factors. In the past decade, several loci and >100 genes have been found to be associated with the disease in at least one population. Among these loci, region 12q13-24 has been implicated in asthma etiology in multiple populations, suggesting that it harbors one or more asthma ...
Lenuta Balaci +41 more
openaire +4 more sources
Soluble triggering receptor on myeloid cells-1 is expressed in the course of non-infectious inflammation after traumatic lung contusion : a prospective cohort study [PDF]
, 2011 Introduction: The triggering receptor expressed on myeloid cells-1 (TREM-1) is known to be expressed during bacterial infections. We investigated whether TREM-1 is also expressed in non-infectious inflammation following traumatic lung contusion. Methods:
Bingold, Tobias Michael +7 more
core +1 more source
Frontiers in Medicine, 2021 Programs to prevent mother-to-child HIV transmission do not reduce the number of infants exposed during pregnancy and breastfeeding. HIV-exposed but uninfected children (HEU) present higher risk of morbidity and mortality than HIV-unexposed and ...
Marina Rubio-Garrido +8 more
doaj +1 more source
Immunobiotic Lactobacillus jensenii as immune-health promoting factor to improve growth performance and productivity in post-weaning pigs [PDF]
, 2014 Background: Immunoregulatory probiotics (immunobiotics) have been proposed to improve piglets' immune system to avoid intestinal infections and reduce unproductive inflammation after weaning.
Aso, Hisashi +12 more
core +4 more sources
¿Un califato islámico en el Sahel?
Comillas Journal of International Relations, 2020 Este artículo compara las condiciones políticas, sociales e históricas del Estado de Irak en el momento de la expansión territorial de Daesh con las condiciones políticas, sociales e históricas presentes actualmente en el Estado de Mali. Para el análisis
Iván Santo-Tomás López
doaj +1 more source
Combined carriership of TLR9-1237C and CD14-260T alleles enhances the risk of developing chronic relapsing pouchitis [PDF]
, 2005 AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.
Campieri, M +11 more
core +1 more source
Bifidobacteria upregulate expression of toll-like receptor negative regulators counteracting enterotoxigenic Escherichia coli mediated inflammation in bovine intestinal epitheliocytes [PDF]
, 2013 We previously established a bovine intestinal epithelial cell line (BIE cells) and showed that BIE cells are useful in vitro model system for the study of interactions between pathogenic and beneficial microorganisms and bovine intestinal epithelial ...
Aso, Hisashi +11 more
core +2 more sources