Results 51 to 60 of about 12,977 (200)

What Observations Would an Energetic Neutral Atom Imager Have Made During the Voyager 2 Flyby of Uranus?

Journal of Geophysical Research: Space Physics, Volume 131, Issue 6, June 2026.
Abstract We present large‐scale simulations of energetic neutral atom (ENA) emissions at Uranus from a spacecraft viewpoint. Models of magnetic field, extended hydrogen exosphere, moon‐sourced neutral tori, and proton radiation belt are implemented into a simulator to evaluate the production of ENAs for L $L$ = 1–15.
D. Santos‐Costa, N. André
wiley   +1 more source

Targeting IRAP as a novel strategy to reduce renal fibrosis and injury in chronic kidney disease

, 2023
New strategies are needed to combat pathological organ fibrosis, leading to end stage organ failure. We have identified the enzyme insulin regulated aminopeptidase (IRAP), as one such promising new target.
SHARENYA CHELVARETNAM (17421612)
core   +1 more source

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, Volume 183, Issue 12, Page 3355-3376, June 2026.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

Mechanisms underlying the physiological and pathological roles of IRAP

, 2023
Insulin regulated aminopeptidase (IRAP) is a multifunctional enzyme which has many different roles in maintaining normal physiology and in disease states. For example, our laboratory has identified IRAP as a new target for the treatment of organ fibrosis.
ANIKA ELSE VEAR (14711626)
core   +1 more source

Policy Learning and Policy Development in Innovation Policy: Canada's Global Innovation Clusters Initiative

Canadian Public Administration, Volume 69, Issue 2, Page 167-188, June 2026.
Abstract This article argues that policy learning is essential for effective innovation policy. The ability to learn from past experiments in a reflexive fashion is a prerequisite for effective policy design. The article responds to the call for more applied research to compliment the theoretical framing of policy learning in the literature.
David A. Wolfe, Travis Southin
wiley   +1 more source

Discovery of New Nanomolar Selective IRAP Inhibitors. [PDF]

J Med Chem
Among the M1 family of oxytocinase aminopeptidases, insulin-regulated aminopeptidase IRAP, is an emerging drug target implicated in various biological pathways and particularly in MHC-I antigen presentation through amino-terminal trimming of exogenous cross-presented peptides.
He B, Karroum NB, Gealageas R, Mauvais FX, Warenghem S, Roignant M, Kraupner N, Lam BV, Azaroual N, Ultré V, Rech A, Lesire L, Couturier C, Leroux F, van Endert P, Deprez B, Deprez-Poulain R.   +16 more
europepmc   +3 more sources

Transposon-Based Tagging: IRAP, REMAP, and iPBS [PDF]

, 2013
Retrotransposons are a major component of virtually all eukaryotic genomes, which makes them useful as molecular markers. Various molecular marker systems have been developed that exploit the ubiquitous nature of these genetic elements and their property of stable integration into dispersed chromosomal loci that are polymorphic within species.
Ruslan, Kalendar, Alan H, Schulman
openaire   +2 more sources

An Aeolian Depositional Sequence Shaped by Near‐Surface Water at the Base of the Layered Sulfate Unit, Gale Crater, Mars

Journal of Geophysical Research: Planets, Volume 131, Issue 5, May 2026.
Abstract The basal strata of the orbitally defined Layered Sulfate unit (LSu) in Gale crater, Mars, marks the end of a major mineralogical transition from clay‐to sulfate‐bearing stratigraphy. This has previously been attributed to a period of significant aridification of Gale's climate. Here, we present ground‐based observations by the Curiosity rover
Amelie L. Roberts, Sanjeev Gupta, Aster Cowart, Lauren A. Edgar, William Rapin, William E. Dietrich, Edwin Kite, Steven G. Banham, Joel M. Davis, Claire A. Mondro, Dave M. Rubin, John P. Grotzinger, William Farrand, Linda Kah, Kevin Lewis, Alexander Bryk, Catherine Weitz, Rachel Y. Sheppard, Gwénaël Caravaca, Stéphane Le Mouélic, Emma R. Harris, Patrick J. Gasda, Aileen Yingst, Deirdra Fey, Jeffrey R. Johnson, Gerhard P. Paar, Abigail A. Fraeman, Ashwin R. Vasavada   +27 more
wiley   +1 more source

The Dissipation Regime of Turbulence on Mars Observed With Microphone Data From the Mars 2020 Perseverance Rover

Geophysical Research Letters, Volume 53, Issue 8, 28 April 2026.
Abstract Turbulent winds are a regular occurrence in planetary boundary layers. Turbulence affects mixing, energy fluxes and forcing on the surface environment. Energy injected into an atmosphere generates eddies of many scales down to a size where molecular viscous forces dominate, termed the Kolmogorov length scale.
Alexander E. Stott, Naomi Murdoch, Martin Gillier, German Martinez, Tanguy Bertrand, Ralph Lorenz, Claire Newman, Ricardo Hueso, Manuel de la Torre Juárez, Donald Banfield, Sylvestre Maurice, Baptiste Chide, Jose Antonio Rodriguez Manfredi, David Mimoun   +13 more
wiley   +1 more source

Variability for resistance to Fusarium solani culture filtrate and fusaric acid among somaclones in pea

Biologia Plantarum, 2013
Pea (Pisum sativum L.) somaclones of cultivars Adept, Komet and Bohatýr were obtained after selection in vitro with Fusarium solani filtrate and fusaric acid (FA). R2 regenerants were analysed by random amplification of polymorphic DNA (RAPD; OPAB4, P-14,
J. Horáček, L. Švábová, P. Šarhanová, A. Lebeda   +3 more
doaj   +1 more source