Results 1 to 10 of about 74,786 (193)
Angiotensin IV does not exert prothrombotic effects in vivo [PDF]
Journal of Molecular and Cellular Cardiology PlusThrombosis and thromboembolism are serious clinical complications of cardiovascular diseases and are among the leading causes of mortality worldwide. Dysregulation of the renin-angiotensin system is associated with an increased incidence of thrombotic ...
Qifang Wu +5 more
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Cognitive-enhancing effects of angiotensin IV [PDF]
BMC Neuroscience, 2008 Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and it has been shown to enhance acquisition, consolidation and recall in animal models of learning and memory when administered centrally or peripherally.
Gard Paul R
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From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase [PDF]
Frontiers in Pharmacology, 2020 It was reported three decades ago that intracerebroventricular injection of angiotensin IV (Ang IV, Val-Tyr-Ile-His-Pro-Phe) improved memory and learning in the rat. There are several explanations for these positive effects of the hexapeptide and related
Mathias Hallberg, Mats Larhed
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Effect of berberine on PPARα-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV [PDF]
Pharmaceutical Biology, 2017 Context: The available treatments for the abnormal proliferation of vascular smooth muscle cells (VSMCs) are still dismal. Berberine has been demonstrated to possess extensive medicine activity, yet relatively little is known about its effect on VSMCs ...
Hongmei Qiu +7 more
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Angiotensin IV Receptors in the Rat Prefrontal Cortex: Neuronal Expression and NMDA Inhibition [PDF]
BiomedicinesBackground: N-methyl-D-aspartate type glutamate receptors (NMDARs) are fundamental to neuronal physiology and pathophysiology. The prefrontal cortex (PFC), a key region for cognitive function, is heavily implicated in neuropsychiatric disorders ...
Zsolt Tamás Papp +11 more
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Brain angiotensin II and angiotensin IV receptors as potential Alzheimer's disease therapeutic targets. [PDF]
Geroscience, 2020 Alzheimer's disease (AD) is a neurodegenerative disorder that is multifactorial in nature. Yet, despite being the most common form of dementia in the elderly, AD's primary cause remains unknown. As such, there is currently little to offer AD patients as the vast majority of recently tested therapies have either failed in well-controlled clinical trials
Royea J, Hamel E.
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Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies. [PDF]
Neurosci Biobehav Rev, 2018 To explore effects of the brain renin-angiotensin system (RAS) on cognition.Systematic review of experimental (non-human) studies assessing cognitive effects of RAS peptides angiotensin-(3-8) [Ang IV] and angiotensin-(1-7) [Ang-(1-7)] and their receptors, the Ang IV receptor (AT4R) and the Mas receptor.Of 450 articles identified, 32 met inclusion ...
Ho JK, Nation DA.
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Effects of angiotensin peptides on colonic motility in rats [PDF]
Annals of Coloproctology, 2023 Purpose Renin-angiotensin system (RAS) is involved in the pathophysiology of colonic inflammation. The aim of this study was to investigate whether small angiotensins (Angs) peptides play a role in the regulation of colonic motility and their roles are ...
Gi Won Ha, Jong Hun Kim, Suhn Hee Kim
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Bioactive angiotensin peptides: focus on angiotensin IV [PDF]
Journal of the Renin-Angiotensin-Aldosterone System, 2001 JRAAS 2001;2:205-10 Introduction The renin-angiotensin system (RAS) was initially identified as a circulating humoral system with the effector peptide,angiotensin II (Ang II),generated by an enzymatic cascade. Angiotensinogen, which is synthesised in the liver, is cleaved by renin,a product of the juxtaglomerular cells of the kidney, to form ...
T, Mustafa +5 more
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Current Issues in Molecular Biology, 2022 Angiotensin IV (Ang IV), a metabolite of Angiotensin II, is a bioactive hexapeptide that inhibits the insulin-regulated aminopeptidase (IRAP). This transmembrane zinc metallopeptidase with many biological functions has in recent years emerged as a new ...
Frida Stam +8 more
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