Results 11 to 20 of about 74,786 (193)

Alzheimer's, Angiotensin IV and an Aminopeptidase

Biological and Pharmaceutical Bulletin, 2004
The angiotensin AT(4) receptor was originally defined as the specific, high affinity binding site for the hexapeptide angiotensin IV (Ang IV). Subsequently, the peptide LVV-hemorphin 7 was also demonstrated to be a bioactive ligand of the AT(4) receptor.
Albiston, Anthony Lloyd, Fernando, Ruani, Ye, Siying, Peck, Grantley Ross, Chai, Siew Yeen   +4 more
openaire   +5 more sources

The Renin–Angiotensin System Modulates SARS-CoV-2 Entry via ACE2 Receptor

Viruses
The renin–angiotensin system (RAS) plays a central role in cardiovascular regulation and has gained prominence in the pathogenesis of Coronavirus Disease 2019 (COVID-19) due to the critical function of angiotensin-converting enzyme 2 (ACE2) as the entry ...
Sophia Gagliardi, Tristan Hotchkin, Hasset Tibebe, Grace Hillmer, Dacia Marquez, Coco Izumi, Jason Chang, Alexander Diggs, Jiro Ezaki, Yuichiro J. Suzuki, Taisuke Izumi   +10 more
doaj   +2 more sources

Assessment of biological activity of novel peptide analogues of angiotensin IV

Journal of Pharmacy and Pharmacology, 2011
AbstractObjectivesAngiotensin IV (Ang IV) is a metabolite of angiotensin II which acts on specific AT4 receptors identified as the enzyme insulin regulated aminopeptidase (IRAP). The transduction process of these receptors is unresolved, but Ang IV inhibits the aminopeptidase activity.
Gard, Paul, Olivier, George, Golding, B., Bourner, C., Dang, T., Haliru, H., Higgins, E., Kimberley, H., Loginova, O., Madhavi, S., Ryan, D.   +10 more
openaire   +3 more sources

Quantum Mechanics/Molecular Mechanics Simulations Distinguish Insulin-Regulated Aminopeptidase Substrate (Oxytocin) and Inhibitor (Angiotensin IV) and Reveal Determinants of Activity and Inhibition. [PDF]

J Chem Inf Model
Insulin-regulated aminopeptidase (IRAP) is a zinc-dependent metalloenzyme identified as a novel target for combating diabetes-induced diseases due to its crucial role in glucose metabolism and insulin sensitivity regulation.
Hanževački M, Twidale RM, Lang EJM, Gerrard W, Wright DW, Stojevic V, Mulholland AJ.   +6 more
europepmc   +3 more sources

Angiotensin IV Receptors Mediate the Cognitive and Cerebrovascular Benefits of Losartan in a Mouse Model of Alzheimer's Disease. [PDF]

J Neurosci, 2017
The use of angiotensin receptor blockers (ARBs) correlates with reduced onset and progression of Alzheimer's disease (AD). The mechanism depicting how ARBs such as losartan restore cerebrovascular and cognitive deficits in AD is unknown. Here, we propose
Royea J, Zhang L, Tong XK, Hamel E.
europepmc   +2 more sources

Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model

PPAR Research, 2020
The activation of the renin-angiotensin system (RAS) participates in the development of metabolic syndrome (MetS) and in heart failure. PPAR-alpha activation by fenofibrate reverts some of the effects caused by these pathologies.
María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, María Esther Rubio-Ruíz   +7 more
doaj   +1 more source

Interactions of angiotensin IV and oxytocin on behaviour in mice [PDF]

Journal of the Renin-Angiotensin-Aldosterone System, 2007
Introduction. Angiotensin (Ang) IV enhances learning and memory in rats but there are strain differences in its effects in mice. Oxytocin (OT) also influences learning and memory in rats and mice and, in the light of the proposed effects of Ang IV on oxytocinase, the hypothesis that the effects of Ang IV on cognition in mice involve OT was tested.
Paul R, Gard, Pauline, Daw, Zhila Sayyad, Mashhour, Paula, Tran   +3 more
openaire   +2 more sources

Characterization of the intrarenal renin‐angiotensin system in cats with naturally occurring chronic kidney disease

Journal of Veterinary Internal Medicine, 2022
Background The role of the renin‐angiotensin‐aldosterone system in cats with chronic kidney disease (CKD) is incompletely understood. Objective To characterize components of the intrarenal renin‐angiotensin system (RAS) in cats with CKD.
Bianca N. Lourenço, Amanda E. Coleman, Roy D. Berghaus, Jaime L. Tarigo, Chad W. Schmiedt, Scott A. Brown   +5 more
doaj   +1 more source

Local renin angiotensin system and sperm DNA fragmentation

Asian Journal of Andrology, 2022
The renin angiotensin system (RAS) appears to influence male fertility at multiple levels. In this work, we analyzed the relationship between the RAS and DNA integrity.
María Victoria Aparicio Prieto, María Victoria Rodríguez Gallego, Asier Valdivia Palacín, Yosu Franco Iriarte, Gotzone Hervás Barbara, Enrique Echevarría Orella, Luis Casis Saenz   +6 more
doaj   +1 more source

Comparative effects of angiotensin II and its degradation products angiotensin III and angiotensin IV in rat aorta [PDF]

British Journal of Pharmacology, 1995
In the present study, the contractile effects of angiotensin III (AIII) and angiotensin IV (AIV) compared with those of angiotensin II (All) were determined in rat aortic ring preparations.All three peptides caused concentration‐dependent contractions with similar maximal responses.
Q, Li, L, Zhang, M, Pfaffendorf, P A, van Zwieten   +3 more
openaire   +2 more sources