From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase [PDF]
Frontiers in Pharmacology, 2020 It was reported three decades ago that intracerebroventricular injection of angiotensin IV (Ang IV, Val-Tyr-Ile-His-Pro-Phe) improved memory and learning in the rat. There are several explanations for these positive effects of the hexapeptide and related
Mathias Hallberg, Mats Larhed
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The Discovery of Insulin-Regulated Aminopeptidase (IRAP) Inhibitors: A Literature Review [PDF]
Frontiers in Pharmacology, 2020 Insulin-Regulated Aminopeptidase (IRAP, EC 3.4.11.3) is a multi-tasking member of the M1 family of zinc aminopeptidases. Among its diverse biological functions, IRAP is a regulator of oxytocin levels during late stages of pregnancy, it affects cellular ...
Dimitris Georgiadis +4 more
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Sex- and time-dependent role of insulin regulated aminopeptidase in lipopolysaccharide-induced inflammation [PDF]
Frontiers in ImmunologyThe enzyme, insulin regulated aminopeptidase (IRAP), is expressed in multiple immune cells such as macrophages, dendritic cells and T cells, where it plays a role in regulating the innate and adaptive immune response.
Anika Vear +11 more
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Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain [PDF]
Frontiers in Molecular Biosciences, 2020 Placental leucine aminopeptidase/insulin-regulated aminopeptidase (P-LAP/IRAP) regulates vasopressin and oxytocin levels in the brain and peripheral tissues by controlled degradation of these peptides.
Yoshikuni Goto +4 more
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Editorial: Physiological, Pathological Roles and Pharmacology of Insulin Regulated Aminopeptidase [PDF]
Frontiers in Molecular Biosciences, 2021 Siew Yeen Chai +2 more
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Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase [PDF]
Pharmaceuticals, 2021 Insulin-Regulated aminopeptidase (IRAP) is a zinc-dependent aminopeptidase with several important biological functions and is an emerging pharmaceutical target for cognitive enhancement and immune system regulation.
Ioannis Temponeras +3 more
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Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation [PDF]
Frontiers in Immunology, 2022 The function of intracellular trafficking in immune-complex triggered inflammation remains poorly understood. Here, we investigated the role of Insulin-Regulated Amino Peptidase (IRAP)-positive endosomal compartments in Fc receptor (FcR)-induced ...
Manuela Bratti +16 more
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Insulin-Regulated Aminopeptidase Inhibition Ameliorates Metabolism in Obese Zucker Rats [PDF]
Frontiers in Molecular Biosciences, 2020 The aim of our study was to determine the influence of inhibition of insulin-regulated aminopeptidase/oxytocinase (IRAP) on glucose tolerance and metabolism of skeletal muscle and visceral adipose tissue in obese Zucker rats.
Katarina Krskova +6 more
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Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke [PDF]
Scientific Reports, 2023 Stroke is a leading cause of mortality and morbidity with a paucity of effective pharmacological treatments. We have previously identified insulin-regulated aminopeptidase (IRAP) as a potential target for the development of a new class of drugs for the ...
Jonathon Telianidis +6 more
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Role of insulin-regulated aminopeptidase as potential biomarker in insulin resistant polycystic ovary syndrome patients [PDF]
Archives of Endocrinology and MetabolismObjective: To measure serum insulin-regulated aminopeptidase levels in women diagnosed with polycystic ovary syndrome and to investigate their potential contribution of these levels to the development of insulin resistance, which plays a central role in ...
Osman Köse +5 more
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