Results 31 to 40 of about 3,708 (156)

Small potent ligands to the insulin‐regulated aminopeptidase (IRAP)/AT₄ receptor

Journal of Peptide Science, 2007
AbstractAngiotensin IV analogs encompassing aromatic scaffolds replacing parts of the backbone of angiotensin IV have been synthesized and evaluated in biological assays. Several of the ligands displayed high affinities to the insulin‐regulated aminopeptidase (IRAP)/AT4 receptor.
Axen, A., Andersson, H, Lindeberg, G, Ronnholm, H, Kortesmaa, J, Demaegdt, Heidi, Vauquelin, Georges, Karlen, A., Hallberg, M.   +8 more
openaire   +4 more sources

Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart [PDF]

Cellular and Molecular Life Sciences
Excessive accumulation of long-chain fatty acids (LCFAs) in cardiomyocytes leads to cardiac lipid-induced insulin resistance (CLIR), impairing insulin signaling and glucose uptake.
Francesco Schianchi, Jeroen Guns, Freek G. Bouwman, Jeroen F.J. Bogie, Miranda Nabben, Agnieszka Strzelecka, Rick van Leeuwen, Dimitris Kapsokalyvas, Kaitlyn M.J.H. Dennis, Lisa C. Heather, Shujin Wang, Jan F.C. Glatz, Dietbert Neumann, Joost J.F.P. Luiken   +13 more
doaj   +2 more sources

Decreased Levels of Insulin-Regulated Aminopeptidase (IRAP) in Gestational Diabetes Mellitus: A Prospective Cohort Study

Clinical and Experimental Obstetrics & Gynecology
Background: Insulin-regulated aminopeptidase (IRAP) is involved in insulin sensitivity and glucose metabolism and is important in the pathophysiology of type 2 diabetes.
Osman Köse, Koray Gök, Elif Köse, Sezen Irmak Gözükara, Abdullah Tüten, Mehmet Sühha Bostancı   +5 more
doaj   +2 more sources

Author Correction: Comparative study of Dapagliflozin versus Glimepiride effect on insulin regulated aminopeptidase (IRAP) and interleukin-34 (IL-34) in patient with type 2 diabetes mellitus [PDF]

Scientific Reports, 2023
Rania Zekry, Gamal A. Omran, Nashwa M. El-Gharbawy, Rehab H. Werida   +3 more
doaj   +2 more sources

AKT/AMPK-mediated phosphorylation of TBC1D4 disrupts the interaction with insulin-regulated aminopeptidase [PDF]

Journal of Biological Chemistry, 2021
Samaneh Eickelschulte, Sonja Hartwig, Ben Leiser   +2 more
exaly   +2 more sources

IRAP Drives Ribosomal Degradation to Refuel Energy for Platelet Activation during Septic Thrombosis [PDF]

Advanced Science
Platelets play crucial roles in multiple pathophysiological processes after energy‐dependent activation. It is puzzling how such a small cellular debris has abundant energy supply.
Baichuan Xu, Xianpeng Ye, Kangfu Sun, Liang Chen, Zhaoyang Wen, Qigang Lan, Jun Chen, Mo Chen, Mingqiang Shen, Song Wang, Yang Xu, Xi Zhang, Jinghong Zhao, Junping Wang, Shilei Chen   +14 more
doaj   +2 more sources

Discovery of Novel Allosteric Inhibitor Hits for Insulin-Regulated Aminopeptidase Provides Insights on Enzymatic Mechanism [PDF]

ACS Omega
Galateia Georgaki, Nikoletta-Maria Koutroumpa, Panagiotis Lagarias, Antreas Afantitis, Athanasios Papakyriakou, Efstratios Stratikos   +5 more
doaj   +2 more sources

Trans-Modulation of the Somatostatin Type 2A Receptor Trafficking by Insulin-Regulated Aminopeptidase Decreases Limbic Seizures. [PDF]

J Neurosci, 2015
Within the hippocampus, the major somatostatin (SRIF) receptor subtype, the sst2A receptor, is localized at postsynaptic sites of the principal neurons where it modulates neuronal activity.
De Bundel D, Fafouri A, Csaba Z, Loyens E, Lebon S, El Ghouzzi V, Peineau S, Vodjdani G, Kiagiadaki F, Aourz N, Coppens J, Walrave L, Portelli J, Vanderheyden P, Chai SY, Thermos K, Bernard V, Collingridge G, Auvin S, Gressens P, Smolders I, Dournaud P.   +21 more
europepmc   +3 more sources

Enhanced recombinant expression and purification of human IRAP for biochemical and crystallography studies

Biochemistry and Biophysics Reports, 2021
Insulin-regulated aminopeptidase (IRAP) in humans is a membrane bound enzyme that has multiple functions. It was first described as a companion protein of the insulin-responsive glucose transporter, Glut4, in specialized vesicles.
Lufei Sui, Hwai-Chen Guo
doaj   +1 more source

Some notes on insulin-regulated aminopeptidase in depression [PDF]

International Journal of Neuropsychopharmacology, 2013
We read with great interest the recently published article by Loyens et al. (2012) about the putative role of insulin-regulated aminopeptidase (IRAP) in mediating the antidepressant-like effects of oxytocin (OT) and wish to comment from a ‘human’ perspective on selected aspects of this topic.
Susan, Müller, Uwe, Lendeckel, Henrik, Dobrowolny, Johann, Steiner, Bernhard, Bogerts, Hans-Gert, Bernstein   +5 more
openaire   +2 more sources