Results 1 to 10 of about 38,797 (256)
Biochemical Journal, 2022 Insulin rapidly stimulates GLUT4 translocation and glucose transport in fat and muscle cells. Signals from the occupied insulin receptor are translated into downstream signalling changes in serine/threonine kinases within timescales of seconds, and this is followed by delivery and accumulation of the glucose transporter GLUT4 at the plasma membrane ...
Fazakerley, Daniel +2 more
openaire +4 more sources
DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation [PDF]
Journal of Biological Chemistry, 2017 Insulin-dependent translocation of glucose transporter 4 (Glut4) to the plasma membrane plays a key role in the dynamic regulation of glucose homeostasis. We recently showed that this process is critically dependent on palmitoylation of Glut4 at Cys-223.
Keyong Du, Bernhard Lüscher
exaly +3 more sources
Attenuation of Differentiation of Mesenchymal Stem Cells Into Adipocytes by Co-administration of Calcium and All-trans Retinoic Acid [PDF]
Avicenna Journal of Medical Biochemistry, 2023 Background: Adipogenesis is affected by multiple factors, among which all-trans retinoic acid (ATRA) and Ca2+are considered important factors. Objectives: This study aimed to evaluate the effect of calcium, ATRA, and their underlying molecular ...
Farjam Goudarzi +5 more
doaj +1 more source
Effect of insulin and cinnamon extract on spatial memory and gene expression of GLUT1, 3, and 4 in streptozotocin-induced Alzheimer’s model in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Since diminished hippocampal insulin signaling leads to memory impairment, insulin resistance and hyperinsulinemia are probably associated with Alzheimer’s disease (AD).
Elham Sajadi +3 more
doaj +1 more source
Regulatory effects of protein S-acylation on insulin secretion and insulin action [PDF]
Open Biology, 2021 Post-translational modifications (PTMs) such as phosphorylation and ubiquitination are well-studied events with a recognized importance in all aspects of cellular function.
Luke H. Chamberlain +2 more
doaj +1 more source
Molecular Endocrinology, 2008 Despite being one of the first recognized targets of insulin action, the acceleration of glucose transport into muscle and fat tissue remains one of the most enigmatic processes in the insulin action cascade. Glucose transport is accomplished by a shift in the distribution of the insulin-responsive glucose transporter GLUT4 from intracellular ...
Larance, Mark +2 more
openaire +3 more sources
Malang Neurology Journal, 2021 Background: Identification of appropriate biomarker involved in the pathophysiology of diabetes-associated cognitive decline in animal model is necessary.
Herpan Syafii Harahap +8 more
doaj +1 more source
A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology
Life Science Alliance, 2023 The authors describe a high-throughput method for measuring endogenous GLUT4 and transferrin receptor translocation in adipocytes. They reveal that this method has advantages over studying GLUT4 trafficking using overexpressed GLUT4 reporters, which are ...
Alexis Diaz-Vegas +13 more
doaj +1 more source
Exercise and Sport Sciences Reviews, 2020 The glucose transporter GLUT4 is critical for skeletal muscle glucose uptake in response to insulin and muscle contraction/exercise. Exercise increases GLUT4 translocation to the sarcolemma and t-tubule and, over the longer term, total GLUT4 protein content.
Marcelo, Flores-Opazo +2 more
openaire +3 more sources
Antidiabetic Activity of Methanolic Extract of Artabotrys suaveolens Leaves in 3T3-L1 Cell Line
Journal of Pure and Applied Microbiology, 2020 Artabotrys suaveolens is an evergreen shrub that belongs to the Annonaceae family, traditionally known for its use in regulating menstruation and in treating cholera. Other medicinal properties of this shrub remain to be studied and validated.
Surapaneni Krishna Mohan +4 more
doaj +1 more source