Results 11 to 20 of about 38,797 (256)

An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles [PDF]

BMC Cell Biology, 2008
Abstract Background Insulin stimulates glucose uptake by adipocytes through increasing translocation of the glucose transporter GLUT4 from an intracellular compartment to the plasma membrane. Fusion of GLUT4-containing vesicles at the cell surface is thought to involve phospholipase D activity, generating the ...
Welsh Gavin I, Leney Sophie E, Pettitt Trevor R, Heyward Catherine A, Tavaré Jeremy M, Wakelam Michael JO   +5 more
openaire   +5 more sources

Structural and Functional Evolution of Glucose Transporter 4 (GLUT4): A Look at GLUT4 in Fish [PDF]

, 2014
The insulin-responsive glucose transporter GLUT4 was first described in 1988 as a result of studies on the regulation of glucose metabolism by insulin [1]. Soon after the discovery of GLUT4, several groups cloned GLUT4 in the human [2], rat [3,4] and mouse [5].
Marín Juez, Rubén, Capilla Campos, Encarnación, Carvalho-Simoes, Francisco, Camps Camprubí, Marta, Planas Vilarnau, Josep   +4 more
openaire   +4 more sources

Study of Phenytoin Effect on the genes involved in glucose and lipid metabolism expression in liver: A mouse model study

Journal of Current Biomedical Reports, 2021
Phenytoin as an anti-seizure medication, is useful for the prevention of tonic-clonic seizures and focal seizures. In this study we focused on the probable effects of Phenytoin drug on gene expression profile of liver related to lipid metabolism balance ...
Fatemeh Samimi, Ali Mohammad Ahadi, Nafiseh Boroomand, Farzaneh Mohammadzadeh Rostami   +3 more
doaj   +1 more source

The GLUT4 Glucose Transporter [PDF]

Cell Metabolism, 2007
Few physiological parameters are more tightly and acutely regulated in humans than blood glucose concentration. The major cellular mechanism that diminishes blood glucose when carbohydrates are ingested is insulin-stimulated glucose transport into skeletal muscle.
Huang, Shaohui, Czech, Michael P.
openaire   +2 more sources

Effects of simultaneous intervention of aerobic training and berberine supplementation on AMPK and GLUT4 gene expression in the quadriceps muscle of diabetic male rats [PDF]

فیزیولوژی ورزش و فعالیت بدنی
Background and Purpose: Diabetes is a metabolic disease associated with increased blood glucose. Based on the results of previous research, physical activity, and herbal supplements containing antioxidants and anti-inflammatory agents play an important ...
Mahboobe Zaefarani Arani, Javad Ramezani, Saeid Naghibi   +2 more
doaj   +1 more source

Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4 [PDF]

, 2011
Background: Insulin stimulates exocytosis of GLUT4 from an intracellular store to the cell surface of fat and muscle cells. Fusion of GLUT4-containing vesicles with the plasma membrane requires the SNARE proteins Syntaxin 4, VAMP2 and the regulatory Sec1/
Aran, V., Nia J Bryant, Gould, G.W., Gould, Gwyn W, Veronica Aran, Bryant, Nia J, Aran, Veronica, Gwyn W Gould, Bryant, N.J.   +8 more
core   +1 more source

Advances in the Study of Endometrial Receptivity and Glucose Metabolism Mechanisms in Insulin Resistance. [PDF]

Endocrinol Diabetes Metab
This article systematically reviews how insulin resistance (IR) disrupts endometrial receptivity by interfering with glucose metabolism mechanisms, ultimately leading to infertility in patients with Polycystic Ovary Syndrome (PCOS). ABSTRACT Introduction Insulin resistance (IR) is one of the important pathologic bases of polycystic ovary syndrome (PCOS)
Huang SY, Chen SR, Chen WH, Zheng LT, Xu J, Shi YC, Lin S, Shi QR.   +7 more
europepmc   +2 more sources

GLUT4 exocytosis

Journal of Cell Science, 2011
GLUT4 is an insulin-regulated glucose transporter that is responsible for insulin-regulated glucose uptake into fat and muscle cells. In the absence of insulin, GLUT4 is mainly found in intracellular vesicles referred to as GLUT4 storage vesicles (GSVs).
Jacqueline, Stöckli, Daniel J, Fazakerley, David E, James   +2 more
openaire   +3 more sources

Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c In Vitro [PDF]

, 2008
Background: Translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the plasma membrane is responsible for the increased rate of glucose transport into fat and muscle cells in response to insulin.
Nia J Bryant, Gould, G.W., Veronica Aran, James A McNew, Gwyn W Gould, McNew, J.A., Bryant, N.J., Aran Veronica, Avani Verma, Gould Gwyn W., Aran-Ponte, V., Fiona M Brandie, Bryant Nia J., Verma Avani, Brandie Fiona M., McNew James A., Brandie, F.M., Verma, A.   +17 more
core   +1 more source

Antidiabetic effects of a lipophilic extract obtained from flowers of Wisteria sinensis by activating Akt/GLUT4 and Akt/GSK3β

Food & Nutrition Research, 2020
Background: Type 2 diabetes mellitus is primarily caused by insulin resistance (IR) in insulin-sensitive tissues, including liver, white adipose tissues (WAT), and skeletal muscles.
Yibing Lv, Wenjie Ren, Yirui Zhang, Yun Huang, Ji Hao, Kun Ma, Yuanren Ma, Xinzhou Yang   +7 more
doaj   +1 more source