Results 21 to 30 of about 38,797 (256)
Insulin regulates Glut4 confinement in plasma membrane clusters in adipose cells. [PDF]
PLoS ONE, 2013 Insulin-stimulated delivery of glucose transporter-4 (GLUT4) to the plasma membrane (PM) is the hallmark of glucose metabolism. In this study we examined insulin's effects on GLUT4 organization in PM of adipose cells by direct microscopic observation of ...
Vladimir A Lizunov +4 more
doaj +1 more source
Glut4 palmitoylation at Cys223 plays a critical role in Glut4 membrane trafficking [PDF]
Biochemical and Biophysical Research Communications, 2015 Recently, we identified Glut4 as a palmitoylated protein in adipocytes. To understand the role of Glut4 palmitoylation in Glut4 membrane trafficking, a process that is essential for maintenance of whole body glucose homeostasis, we have characterized Glut4 palmitoylation. We found that Glut4 is palmitoylated at Cys223 and Glut4 palmitoylation at Cys223
Wenying, Ren, Yingmin, Sun, Keyong, Du
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GLUT4 as A Protein Target for T2DM Therapy with Natural Compounds
Biology, Medicine & Natural Product Chemistry, 2023 WHO reported 1.9 million death cases of diabetes patients in 2019. Diabetes is caused by damage in the pancreas which resulted in a lack of insulin or insulin resistance.
Vivi Hendra Sutandar +2 more
doaj +1 more source
Thirty sweet years of GLUT4 [PDF]
Journal of Biological Chemistry, 2019 A pivotal metabolic function of insulin is the stimulation of glucose uptake into muscle and adipose tissues. The discovery of the insulin-responsive glucose transporter type 4 (GLUT4) protein in 1988 inspired its molecular cloning in the following year.
Amira Klip +2 more
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Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes [PDF]
, 2014 Aims/hypothesis: Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP ...
Hamilton, D. Lee +26 more
core +1 more source
Regulation of glucose transport in skeletal muscle during and after exercise
Journal of Physical Fitness and Sports Medicine, 2012 Exercise is widely perceived to be an effective tool for prevention and treatment of type 2 diabetes, since reducing visceral fat accumulation by means of exercise protects against insulin resistance.
Kentaro Kawanaka
doaj +1 more source
Potential role of galanine in the treatment of type 2 diabetes mellitus
Сахарный диабет, 2020 The growing incidence of diabetes mellitus requires the optimizing of existing approaches and searching for new ones to treat this disease. It is necessary to study the features of other regulators that play a significant role in the process of glucose ...
Igor Vladimirovich Dobrokhotov +2 more
doaj +1 more source
GLUT4 trafficking in a test tube [PDF]
Cell Metabolism, 2005 Insulin regulates glucose transport in muscle and fat cells by stimulating the translocation of GLUT4 from intracellular vesicles to the plasma membrane. In this issue of Cell Metabolism, Holman and colleagues reconstitute this process in vitro, providing a system that promises new breakthroughs in our understanding of this important metabolic process.
Ramm, Georg, James, David E.
openaire +2 more sources
Pharmaceutical Biology, 2017 Context: Caffeic acid methyl (CAME) and ethyl (CAEE) esters stimulate glucose uptake and AMP-activated protein kinase (AMPK) in C2C12 myocytes (ATCC® CRL-1772TM).
Hoda M. Eid +3 more
doaj +1 more source
Asian Pacific Journal of Tropical Biomedicine, 2019 Objective: To evaluate the antidiabetic effect of Callicarpa nudiflora extract in streptozotocin- induced diabetic rats. Methods: The chemical constituents in Callicarpa nudiflora extract were identified by UPLC- Q-TOF-MS. Callicarpa nudiflora extract (0.
Wen-Yu Ma +5 more
doaj +1 more source