Results 41 to 50 of about 38,797 (256)

Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes [PDF]

PeerJ, 2020
Insulin-stimulated glucose transport is a characteristic property of adipocytes and muscle cells and involves the regulated delivery of glucose transporter (GLUT4)-containing vesicles from intracellular stores to the cell surface.
Silke Morris, Niall D. Geoghegan, Jessica B.A. Sadler, Anna M. Koester, Hannah L. Black, Marco Laub, Lucy Miller, Linda Heffernan, Jeremy C. Simpson, Cynthia C. Mastick, Jon Cooper, Nikolaj Gadegaard, Nia J. Bryant, Gwyn W. Gould   +13 more
doaj   +2 more sources

Recent Developments in Diabetes Management: Exploring Receptors, Pathways, and Compounds

BIO Integration
Diabetes mellitus (DM) is a widespread metabolic disorder with profound effects on vital organs. Often referred to as a “systemic” or “multi-organ” disorder due to the impact on key organs, such as the kidneys, pancreas, eyes, and heart, DM is ...
Pallavi Pandey, Vikash Jakhmola, Supriyo Saha, Anand Gaurav   +3 more
doaj   +1 more source

The intracellular helical bundle of human glucose transporter GLUT4 is important for complex formation with ASPL

FEBS Open Bio, 2023
Glucose transporters (GLUTs) are responsible for transporting hexose molecules across cellular membranes. In adipocytes, insulin stimulates glucose uptake by redistributing GLUT4 to the plasma membrane.
Peng Huang, Hannah Åbacka, Daniel Varela, Raminta Venskutonytė, Lotta Happonen, Jonathan S. Bogan, Pontus Gourdon, Mahmood R. Amiry‐Moghaddam, Ingmar André, Karin Lindkvist‐Petersson   +9 more
doaj   +1 more source

GLUT4 in Mouse Endometrial Epithelium: Roles in Embryonic Development and Implantation

Frontiers in Physiology, 2021
GLUT4 is involved in rapid glucose uptake among various kinds of cells to contribute to glucose homeostasis. Prior data have reported that aberrant glucose metabolism by GLUT4 dysfunction in the uterus could be responsible for infertility and increased ...
Yun Long, Yun Long, Yi-cheng Wang, Dong-zhi Yuan, Xin-hua Dai, Lin-chuan Liao, Xue-qin Zhang, Li-xue Zhang, Yong-dan Ma, Yi Lei, Zhi-hui Cui, Jin-hu Zhang, Li Nie, Li-min Yue   +13 more
doaj   +1 more source

Dynamics of the plasma membrane transporter GLUT4 [PDF]

, 2020
Glucose homeostasis in the human body is maintained by hormones of the pancreas, mostly glucagon and insulin. Insulin is secreted when blood glucose levels are high and triggers a signalling cascade that results in glucose uptake via the glucose ...
Morris, Silke
core   +1 more source

Thyme honey reduced hyperglycemia in male rats subjected to chronic unpredictable mild stress: Possible involvement of GLUT4 protein and circulating irisin [PDF]

Avicenna Journal of Phytomedicine
Objective: Chronic stress is a common and fundamental problem in human life all over the world which threatens the health. Stress-induced metabolic disorders are attenuated by natural honey feeding. So, we examined protective impact of thyme honey in the
Maedeh Ghasemi, Forouzan Sadeghimahalli, Hassan Jamali, Azadeh Yazdi, Mohammad reza Sayedi moqadam   +4 more
doaj   +1 more source

GLUT4 translocation and dispersal operate in multiple cell types and are negatively correlated with cell size in adipocytes

Scientific Reports, 2022
The regulated translocation of the glucose transporter, GLUT4, to the surface of adipocytes and muscle is a key action of insulin. This is underpinned by the delivery and fusion of GLUT4-containing vesicles with the plasma membrane.
Anna M. Koester, Angéline Geiser, Peter R. T. Bowman, Sebastian van de Linde, Nikolaj Gadegaard, Nia J. Bryant, Gwyn W. Gould   +6 more
doaj   +1 more source

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

eLife, 2023
Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear.
Jonas R Knudsen, Kaspar W Persson, Carlos Henriquez-Olguin, Zhencheng Li, Nicolas Di Leo, Sofie A Hesselager, Steffen H Raun, Janne R Hingst, Raphaël Trouillon, Martin Wohlwend, Jørgen FP Wojtaszewski, Martin AM Gijs, Thomas Elbenhardt Jensen   +12 more
doaj   +1 more source

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Efek kandungan serat beras analog terhadap ekspresi GLUT4 otot rangka tikus diabetes

Jurnal Gizi Klinik Indonesia, 2019
Effect of analog rice’s fiber on skeletal muscles GLUT4 expression in diabetic rats  Background: Disruption of glucose transportation in skeletal muscle through GLUT4 becomes a problem in diabetes.
Azka Darajat, Elly Nurus Sakinah, Hairrudin Hairrudin   +2 more
doaj   +1 more source