Results 1 to 10 of about 12,977 (200)

Is There an Interplay Between the Functional Domains of IRAP? [PDF]

Frontiers in Cell and Developmental Biology, 2020
As a member of the M1 family of aminopeptidases, insulin regulated aminopeptidase (IRAP) is characterized by distinct binding motifs at the active site in the C-terminal domain that mediate the catalysis of peptide substrates.
Tracey Gaspari, Philip E Thompson, Siew Yeen Chai   +2 more
exaly   +4 more sources

Enhanced recombinant expression and purification of human IRAP for biochemical and crystallography studies

Biochemistry and Biophysics Reports, 2021
Insulin-regulated aminopeptidase (IRAP) in humans is a membrane bound enzyme that has multiple functions. It was first described as a companion protein of the insulin-responsive glucose transporter, Glut4, in specialized vesicles.
Hwai-Chen Guo
exaly   +4 more sources

IRAP Inhibitors: M1-Aminopeptidase Family Inspiration [PDF]

Frontiers in Pharmacology, 2020
The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders.
Nicholas Barlow, Philip E Thompson, Thompson Philip E   +2 more
exaly   +5 more sources

The Discovery of Insulin-Regulated Aminopeptidase (IRAP) Inhibitors: A Literature Review

Frontiers in Pharmacology, 2020
Insulin-Regulated Aminopeptidase (IRAP, EC 3.4.11.3) is a multi-tasking member of the M1 family of zinc aminopeptidases. Among its diverse biological functions, IRAP is a regulator of oxytocin levels during late stages of pregnancy, it affects cellular ...
Dimitris Georgiadis, Georgiadis Dimitris   +1 more
exaly   +3 more sources

Autologous conditioned serum IRAP efficacy for tendon and ligament injuries in horses: An observational study [PDF]

Open Veterinary Journal
Background: Tendon and ligament injuries in equine athletes pose significant challenges, often leading to prolonged recovery, reduced performance, and an increased risk of reinjury.
Simone Della Tommasa, Sarah Raspe, Giacomo Farí, Annarita Imperante, Walter Brehm   +4 more
doaj   +2 more sources

Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart [PDF]

Cellular and Molecular Life Sciences
Excessive accumulation of long-chain fatty acids (LCFAs) in cardiomyocytes leads to cardiac lipid-induced insulin resistance (CLIR), impairing insulin signaling and glucose uptake.
Francesco Schianchi, Jeroen Guns, Freek G. Bouwman, Jeroen F.J. Bogie, Miranda Nabben, Agnieszka Strzelecka, Rick van Leeuwen, Dimitris Kapsokalyvas, Kaitlyn M.J.H. Dennis, Lisa C. Heather, Shujin Wang, Jan F.C. Glatz, Dietbert Neumann, Joost J.F.P. Luiken   +13 more
doaj   +2 more sources

Immunotherapy-Related Pancreatitis: A Case Series of 8 Patients from a High-Volume Oncology Centre [PDF]

Case Reports in Oncology
Introduction: Immune checkpoint inhibitors (ICIs) may lead to immune-related adverse events (irAEs), including the rare complication of immune-related acute pancreatitis (irAP).
Tomás San Martín, Jaime González-Montero, Alberto Espino, Carlos Rojas, Mauricio Burotto   +4 more
doaj   +2 more sources

Sex- and time-dependent role of insulin regulated aminopeptidase in lipopolysaccharide-induced inflammation [PDF]

Frontiers in Immunology
The enzyme, insulin regulated aminopeptidase (IRAP), is expressed in multiple immune cells such as macrophages, dendritic cells and T cells, where it plays a role in regulating the innate and adaptive immune response.
Anika Vear, Anika Vear, Amlan Chakraborty, Amlan Chakraborty, Farnaz Fahimi, Dorota Ferens, Robert Widdop, Chrishan S. Samuel, Tracey Gaspari, Peter M. van Endert, Peter M. van Endert, Siew Yeen Chai   +11 more
doaj   +2 more sources

IRAP Drives Ribosomal Degradation to Refuel Energy for Platelet Activation during Septic Thrombosis [PDF]

Advanced Science
Platelets play crucial roles in multiple pathophysiological processes after energy‐dependent activation. It is puzzling how such a small cellular debris has abundant energy supply.
Baichuan Xu, Xianpeng Ye, Kangfu Sun, Liang Chen, Zhaoyang Wen, Qigang Lan, Jun Chen, Mo Chen, Mingqiang Shen, Song Wang, Yang Xu, Xi Zhang, Jinghong Zhao, Junping Wang, Shilei Chen   +14 more
doaj   +2 more sources

The Rule of Salinity Stress in Activation of Retrotransposition Rate in some Bread Wheat Genotypes. [PDF]

Journal of Agricultural Chemistry and Biotechnology, 2023
The genomes of the six wheat genotypes under study; Masr1, Shandaweel1, Line1. Line2, Giza171 and Sakha94 were extracted. Ten IRAP primers were applied for detecting the rule of salinity stress in activation of retrotransposition rate in the studied ...
S. Demais,, M. Abd EL Sabour, M. bakhit, K. Gad, T. Salim   +4 more
doaj   +1 more source